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- Chapter 1: The US Pharmaceutical Supply Chain
- The pharmaceutical supply chain
- The US pharmaceutical industry
- The role of pharmaceuticals
- US pharmaceutical manufacturers
- Pharmaceutical Research and Manufacturers of America (PhRMA)
- The US biotech industry
- The Biotechnology Industry Organization (BIO)
- Case study: the pharmaceutical and biotech industries at a state level
- The US pharmaceutical market
- The US healthcare system
- Medicare and Medicaid
- State Children’s Health Insurance Program
- Pharmaceutical legal obligations
- Wholesale distribution
- The US wholesale market
- Primary wholesalers
- Secondary wholesalers
- Prescription Drug Marketing Act
- PDMA revisions
- The pedigree requirement
- State-level actions
- US pharmacy market
- Pricing freedom
- US pharmaceutical spending
- Pharmaceutical pricing issues in the US
- US consumer pricing studies
- Outlook for US biopharmaceutical R&D
- Average wholesale price and average sales price
- Internet trading
- Parallel trade
- Chapter 2: The US Wholesale Sector
- Wholesaling in the US
- The Healthcare Distribution Management Association
- The National Coalition of Pharmaceutical Distributors
- Wholesaler consolidation
- Challenges to the dominance of the Big Three
- Case study: RxUSA launches legal challenges against the Big Three
- Cardinal Health Inc
- McKesson Corporation
- AmerisourceBergen Corporation
- Wholesaler technology solutions
- Electronic data interchange
- Collaborative planning, forecasting and replenishment
- Enterprise resource planning
- Order fulfilment packages
- Database technology
- Electronic point-of-sale technology
- Barcoding
- Case study: US highlights benefits of barcode and RFID technologies
- Costs and benefits of EPC/RFID implementation
- Warehouse technology
- Dispensing technology
- Future systems
- The US supply chain and direct distribution
- Development of direct distribution in Europe
- Rationale behind changes in the supply chain
- Challenges to direct distribution in the US
- US wholesalers and globalisation
- Chapter 3: Pharmacy in the US
- The US pharmacy sector
- The American Pharmacists Association
- Case study: the AphA and medication therapy management
- The Academy of Managed Care Pharmacy
- Chain drug stores
- Walgreens
- CVS Caremark
- National Association of Chain Drug Stores
- Case study: the National Trust for Historic Preservation responds to chain drug stores
- Independent pharmacies
- National Community Pharmacists Association
- Mail-order pharmacies
- Online pharmacies
- Case study: PharmacyChecker.com
- Pharmacists and parallel trade
- OTC products
- Rx-to-OTC switching
- Pharmacists and OTCs
- Case study: US pharmacists and Rx-to-OTC switching of allergy products
- Pharmacy benefit managers
- The Pharmaceutical Care Management Association
- Case study: PBMs force patients to switch medications
- The future of US pharmacy
- Patient compliance
- Pharmacies and retail health clinics
- Case study: 2008 survey of patient use of retail health clinics
- Case study: Florida tightens pharmacy regulations
- Biogenerics
- Case study: biogenerics legislation restrictions for pharmacists
- Pharmacy groups launch Project Destiny
- Chapter 4: Protecting the US Supply Chain
- Safeguarding the supply chain
- Disaster planning and the supply chain
- Alternative strategies for mass distribution of medicines
- Case study: US community pharmacies launch Rx History
- Case study: ICERx.org
- Product shortages in the supply chain
- The Food and Drug Administartion (FDA) and drug shortages
- Case study: vaccine shortages and the effect on the supply chain
- Counterfeiting
- Anti-counterfeiting cooperation
- Counterfeiting and the pharmaceutical industry
- FDA anti-counterfeiting measures
- FDA recommendations on combating counterfeits
- Case study: the FDA’s Counterfeit Alert Network
- Case study: AstraZeneca opts for mass serialisation to prevent counterfeiting
- Using nanotechnology to combat counterfeiting
- Case study: FDA Nanotechnology Task Force report
- References
- List of Tables
- Table 1.1 Types of manufacturer medicines
- Table 1.2 The four parts of Medicare
- Table 2.1 Cardinal Health corporate business units
- Table 2.2 McKesson corporate business units
- Table 2.3 AmerisourceBergen Corporation business segments
- Table 2.4 Overall risks of DTP identified by the OFT
- Table 2.5 Challenges for a US direct distribution model
- Table 3.1 Potential patient benefits of medication therapy management
- Table 3.2 Potential competitive advantages of mail-order pharmacies
- Table 3.3 PharmacyChecker.com classification of online pharmacies
- Table 3.4 Top five major players in the pharmacy/retail clinic sector
- Table 3.5 The four components of Project Destiny
- Table 4.1 The application of the HIPAA in emergency situations
- Table 4.2 Recommendations to improve mass distribution of medicines during an emergency through using the private sector
- Table 4.3 ICERx.org partnerships
- Table 4.4 Key areas of focus for the International Medical Products Anti-counterfeiting Taskforce (IMPACT)
- List of Figures
- Figure 1.1 Outline of the traditional supply chain
- Figure 1.2 Global R&D expenditure
- Figure 1.3 Pharmaceutical revenues for major companies (2007)
- Figure 1.4 Pharmaceutical R&D for major companies (2007)
- Figure 1.5 Revenues for major biopharmaceutical companies (2007)
- Figure 1.6 R&D for major biopharmaceutical companies (2007)
- Figure 1.7 US pricing environment compared with Europe and Japan
- Figure 1.8 Ongoing US pharmaceutical R&D dominance
- Figure 1.9 Share of parallel imports in European pharmacy markets
- Figure 2.1 Annual revenues for Cardinal Health and subsidiaries
- Figure 2.2 Annual revenues for McKesson Corporation
- Figure 2.3 Annual revenues for AmerisourceBergen Corporation
- Figure 3.1 Annual revenues for Walgreens
- Figure 3.2 Annual revenues for CVS Caremark
- Figure 3.3 Average annual sales per US pharmacy location
- Figure 3.4 Staff costs as a percentage of US pharmacy operating expenses
- Figure 3.5 Online pharmacy price analysis for select brands
- Figure 3.6 Online pharmacy price analysis for select generics
- Figure 3.7 Flow of goods and payment in the US supply chain
- Figure 4.1 Counterfeit drug cases opened by the FDA
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