Vaccines 2003: World Markets and Developments

1 Executive Summary
1.1 Overview
1.1.1 Pediatric Vaccines
1.1.2 Adult At-Risk Vaccines
1.1.3 Therapeutic Vaccines
1.2 Scope and Objectives of Report
1.3 Methodology of Investigation
1.4 Limitations of the Research

2 Trends and Issues in Vaccine Markets
2.1 Evolution of Pediatric Vaccines
2.1.1 Overview
2.1.2 National Immunization Data
2.1.3 Combination Vaccines: Boon or Bane?
2.1.4 Vaccine Shortages
2.2 Advance of Therapeutic Vaccines
2.2.1 Impact of Genomics and Proteomics
2.2.2 Patents and Intellectual Property
2.2.3 Biodefense Vaccines
2.2.4 HIV/AIDS Vaccine Research
2.3 Bumpy Road to Commercialization
2.3.1 Commercial Alliances and Agreements
2.3.2 Pricing and Marketing Issues
2.3.3 Market Demand Factors
2.4 Global Vaccine Initiatives and Support Organizations
2.4.1 World Organization Support Groups
2.4.2 Vaccine Initiatives by Country

3 Novel Vaccine Technologies
3.1 Introduction
3.2 Vaccine-Enabled Cancer Therapeutics
3.2.1 Description
3.2.2 Therapies in Development
3.3 Vaccine Drug Delivery Technologies
3.3.1 Vaccine Adjuvants.
3.3.2 Vaccine Vectors
3.3.3 Oral, Nasal, Transdermal, and Edible Vaccines
3.4 Emerging Vaccine Targets
3.4.1 Therapeutic Vaccine Strategies
3.4.2 Preventative Vaccine Strategies

4 Market Analysis
4.1 Introduction
4.2 Market and Technology Trends Influencing Projections
4.3 Total World Market Size, Projections, and Shares
4.3.1 Market Analysis By Vaccine Type
4.3.2 Market Analysis by Geography
4.4 Pediatric Vaccines
4.4.1 Market Analysis
4.4.2 Unfavorable Economics of Pediatric Vaccines
4.4.3 Major Players
4.5 Adult At-Risk Vaccines
4.5.1 Market Analysis by Disease Indication
4.5.2 Major Players
4.6 Therapeutic Vaccines
4.6.1 Market Analysis by Technology
4.6.2 Cancer Vaccines
4.6.3 Major Players

5 Company Profiles: Major Players
5.1 Acambis plc (formerly Peptide Therapeutics/OraVax)
5.2 Active Biotech AB
5.3 AltaRex Corp.
5.4 Amgen Inc.
5.5 Antex Biologics Inc.
5.6 Antigenics, Inc.
5.7 Ariad Pharmaceuticals, Inc.
5.8 AstraZeneca Pharmaceuticals
5.9 AVANT Immunotherapeutics, Inc.
5.10 AVAX Technologies, Inc.
5.11 Aventis S.A./Aventis Pasteur
5.12 AVI BioPharma Inc.
5.13 Aviron
5.14 Bavarian Nordic A/S
5.15 Baxter Healthcare Corp.
5.16 Berna Biotech AG
5.17 Biogen, Inc.
5.18 BioSante Pharmaceuticals, Inc.
5.19 British Biotech plc
5.20 Cell Genesys, Inc.
5.21 Cell Pathways, Inc.
5.22 Celltech Group plc
5.23 CEL-SCI Corp.
5.24 Centocor Inc.
5.25 Chiron Corp
5.26 Corixa Corp.
5.27 Dynavax Technologies Corp.
5.28 DynPort Vaccine Co. LLC (DVC)
5.29 Elan Corp., plc
5.30 EntreMed, Inc.
5.31 Epimmune Inc.
5.32 Genentech, Inc.
5.33 Genta Inc.
5.34 Genzyme Corp.
5.35 GlaxoSmithKline
5.36 Human Genome Sciences, Inc.
5.37 IDEC Pharmaceuticals Corp.
5.38 ILEX Oncology Inc.
5.39 ImClone Systems Inc.
5.40 Immunex Corp.
5.41 ImmunoGen, Inc.
5.42 Intercell AG
5.43 Intracel, LLC
5.44 Isis Pharmaceuticals, Inc.
5.45 Maxygen, Inc.
5.46 Medarex Inc.
5.47 MedImmune, Inc.
5.48 Merck & Co., Inc.
5.49 Millennium Pharmaceuticals, Inc.
5.50 Nabi Biopharmaceuticals
5.51 Novartis AG
5.52 Novavax, Inc.
5.53 Oxford BioMedica plc
5.54 PowderJect Pharmaceuticals plc
5.55 Progenics Pharmaceuticals, Inc.
5.56 Protein Design Labs Inc. (PDL)
5.57 Rhein Biotech N.V.
5.58 Roche (F. Hoffmann-La Roche Ltd.)
5.59 Schering-Plough Corp.
5.60 SciClone Pharmaceuticals, Inc.
5.61 Serono SA
5.62 Shire Pharmaceuticals Group plc/Shire Biologics
5.63 Transgene S.A.
5.64 Valentis, Inc.
5.65 VaxGen, Inc.
5.66 Vical Inc.
5.67 Wyeth

6 Company Profiles: Selected Innovators
6.1 Abbott Laboratories
6.2 Abgenix, Inc.
6.3 Advanced Biotherapy Concepts, Inc.
6.4 AEterna Laboratories Inc.
6.5 Agensys, Inc. (formerly UroGenesys, Inc.).
6.6 Anosys, Inc. (formerly AP Cells)
6.7 Antigen Express, Inc.
6.8 Antisoma plc
6.9 Aphton Corp.
6.10 AtheroGenics, Inc.
6.11 Athersys, Inc.
6.12 AVANIR Pharmaceuticals (Xenerex Biosciences)
6.13 Avigen Inc.
6.14 Bharat Biotech International Ltd.
6.15 BioDelivery Sciences International, Inc.
6.16 Bio Farma (Persero)
6.17 Bio-Manguinhos
6.18 Biomira Inc.
6.19 Biosynexus Inc.
6.20 BioVex Ltd.
6.21 Cambridge Antibody Technology plc (CAT)
6.22 CancerVax Corp.
6.23 Celgene Corp.
6.24 Cell Matrix Inc.
6.25 Coley Pharmaceutical Group, Inc.
6.26 Crucell N.V.
6.27 Cytogen Corp.
6.28 CytRx Corp.
6.29 Dendreon Corp.
6.30 DOR Biopharma, Inc.
6.31 Eli Lilly and Co.
6.32 Eos Biotechnology
6.33 Epicyte Pharmaceutical Inc.
6.34 Galenica Pharmaceuticals Inc.
6.35 Genencor International, Inc.
6.36 Genitope Corp.
6.37 Genmab A/S
6.38 GenPhar, Inc.
6.39 GenVec, Inc.
6.40 Hollis-Eden Pharmaceuticals, Inc.
6.41 Hybridon, Inc.
6.42 ID Biomedical Corp.
6.43 igeneon AG
6.44 Immune Response Corp.
6.45 Immunitor
6.46 Immuno-Designed Molecules S.A.
6.47 Immunomedics, Inc.
6.48 INEX Pharmaceuticals Corp.
6.49 Inhibitex, Inc.
6.50 La Jolla Pharmaceutical Co.
6.51 Large Scale Biology Corp.
6.52 LifeTime Pharmaceuticals, Inc.
6.53 LigoCyte Pharmaceuticals, Inc.
6.54 Lorus Therapeutics Inc.
6.55 MediGene AG
6.56 MERIX Bioscience, Inc.
6.57 Micromet AG
6.58 Microscience Ltd.
6.59 Mojave Therapeutics, Inc.
6.60 Neurochem Inc.
6.61 Northwest Biotherapeutics, Inc.
6.62 NovaRx Corp.
6.63 Onyvax Ltd.
6.64 Onyx Pharmaceuticals, Inc.
6.65 Peregrine Pharmaceuticals, Inc. (formerly Techniclone Corp.)
6.66 Pharmexa A/S
6.67 Plexus Vaccine, Inc.
6.68 ProdiGene, Inc.
6.69 Protein Sciences Corp.
6.70 Sanofi-Synthelabo Inc.
6.71 Scancell, Ltd.
6.72 Seattle Genetics, Inc.
6.73 Serum Institute of India, Ltd. (SII)
6.74 Stressgen Biotechnologies Corp.
6.75 Therion Biologics Corp.
6.76 Vasogen Inc.
6.77 Viragen, Inc.
6.78 Xcyte Therapies, Inc.
6.79 Xenova plc
6.80 XTL Biopharmaceuticals Ltd.
6.81 ZymoGenetics, Inc.

7 Company Directory

Appendix A: Vaccine Products by Disease Indication

Appendix B: Vaccine Products by Technology.

List of Tables
Table 2-1 Selected Biodefense and Infectious Disease Vaccine Developers
Table 2-2 Selected HIV Immunotherapy Products
Table 2-3 Selected Company Alliances in Immunotherapy Drug Development 2001-2002
Table 2-4 Selected Failures in Immunotherapy Development
Table 3-1 Selected Vaccine Vector Innovations
Table 3-2 Selected Innovations in Immunotherapy Drug Delivery
Table 4-1 World Vaccine Sales by Vaccine Type 2002
Table 4-2 World Vaccine Sales by Vaccine Type 2007
Table 4-3 World Vaccines Market Share by Vaccine Type 2002
Table 4-4 World Vaccines Market Share by Vaccine Type 2007
Table 4-5 World Vaccines Market Growth Rates by Vaccine Type 2002-2007
Table 4-6 World Vaccine Sales by Geographic Region 2002
Table 4-7 World Vaccine Sales by Geographic Region 2007
Table 4-8 World Vaccines Market Share by Geographic Region 2002
Table 4-9 World Vaccines Market Share by Geographic Region 2007
Table 4-10 World Vaccines Market Growth Rates by Geographic Region 2002-2007
Table 4-11 OECD Country-based Vaccine Manufacturers and Vaccines
Table 4-12 WHO Approved International Pediatric Vaccines as of March 2003
Table 4-13 World Pediatric and At-Risk Vaccine Sales by Company 2002
Table 4-14 World At-Risk Vaccine Sales by Disease Indication 2002
Table 4-15 World At-Risk Vaccine Sales by Disease Indication 2007
Table 4-16 World At-Risk Vaccines Market Share by Disease Indication 2002
Table 4-17 World At-Risk Vaccines Market Share by Disease Indication 2007
Table 4-18 World At-Risk Vaccines Market Growth Rates by Disease Indication 2002-2007
Table 4-19 World Therapeutic Vaccine and Immunotherapy Sales by Technology 2002
Table 4-20 World Therapeutic Vaccine and Immunotherapy Sales by Technology 2007
Table 4-21 World Therapeutic Vaccines and Immunotherapy Market Share by Technology 2002
Table 4-22 World Therapeutic Vaccines and Immunotherapy Market Share by Technology 2007.
Table 4-23 World Therapeutic Vaccines and Immunotherapy Market Growth Rates by Technology 2002-2007
Table 4-24 Selected Therapeutic Vaccine Competitors, Company Revenues 2002
Table 4-25 Selected Therapeutic Vaccines and Immunotherapies, Product Revenues 2002.

List of Figures
Figure 4-1 World Vaccine Sales by Vaccine Type 2002
Figure 4-2 World Vaccine Sales by Vaccine Type 2007
Figure 4-3 World Vaccines Market Share by Vaccine Type 2002
Figure 4-4 World Vaccines Market Share by Vaccine Type 2007
Figure 4-5 World Vaccines Market Growth Rates by Vaccine Type 2002-2007
Figure 4-6 World Vaccine Sales by Geographic Region 2002
Figure 4-7 World Vaccine Sales by Geographic Region 2007
Figure 4-8 World Vaccines Market Share by Geographic Region 2002
Figure 4-9 World Vaccines Market Share by Geographic Region 2007
Figure 4-10 World Vaccines Market Growth Rates by Geographic Region 2002-2007
Figure 4-11 World Pediatric and At-Risk Vaccine Sales by Company 2002
Figure 4-12 World At-Risk Vaccine Sales by Disease Indication 2002
Figure 4-13 World At-Risk Vaccine Sales by Disease Indication 2007
Figure 4-14 World At-Risk Vaccines Market Share by Disease Indication 2002
Figure 4-15 World At-Risk Vaccines Market Share by Disease Indication 2007
Figure 4-16 World At-Risk Vaccines Market Growth Rates by Disease Indication 2002-2007
Figure 4-17 World Therapeutic Vaccine and Immunotherapy Sales by Technology 2002
Figure 4-18 World Therapeutic Vaccine and Immunotherapy Sales by Technology 2007
Figure 4-19 World Therapeutic Vaccines and Immunotherapy Market Share by Technology 2002
Figure 4-20 World Therapeutic Vaccines and Immunotherapy Market Share by Technology 2007
Figure 4-21 World Therapeutic Vaccines and Immunotherapy Market Growth Rates by Technology 2002-2007