1 Executive Summary
1.1 Scope and Objectives of Report
1.2 Target Audience
1.3 Report Methodology
1.3.1 Interviews with Clinical, Technical, and Market Experts
1.3.2 Secondary Data Sources
1.4 Market Summary
2 Introduction to Nanotechnology
2.1 Perspective on Nanotechnology
2.1.1 Definition(s) of Nanotechnology
2.2 Drivers of Medical Nanotechnology
2.2.1 Microscopy
2.2.2 Nucleic Acid Diagnostics/Molecular Diagnostic Assays
2.2.3 Point-Of-Care Testing
2.2.4 Genomics, Proteomics, DNA Biochips, and Microarrays
2.2.5 Self-Assembly
2.2.6 Tissue Engineering and Regenerative Medicine
2.3 Limiters of Medical Nanotechnology
2.4 The Healthcare Environment
2.4.1 Funding and Commercialization
2.4.2 U.S. Government Funding
2.4.3 European and Asian Government Funding
2.4.4 Venture Capital
2.4.5 Market Structure
2.4.6 Regulatory Environment
2.4.7 Marketing
2.5 Notable Nanotechnology Materials
2.5.1 Dendrimers
2.5.2 Carbon Nanotubes
2.5.3 Fullerenes
3 Clinical Diagnostics and Imaging
3.1 Role of Nanotechnology
3.1.1 Objectives and Advantages
3.2 Nanoparticle Tagging and Nanoparticle Probes
3.2.1 Qdots and Eviprobes: Quantum Dot Nanocrystals
3.2.2 Nanobarcodes: Striped Metallic Nanoparticles (Nanoplex Technologies)
3.2.3 Resonant Light Scattering Nanoparticles (Invitrogen)
3.2.4 Gold Nanoparticle Probes (Nanosphere)
3.2.5 Bioconjugated Nanoparticles (University of Florida)
3.3 Sensors
3.3.1 Nanoparticle Tagging Systems
3.3.2 Electronic Sensors
3.3.3 Nanotube and Nanowire Sensors
3.3.4 Single Molecule Detection
3.3.5 Piezoelectric Acoustic Assays/Rupture Event Scanning (Akubio)
3.3.6 Enzymatic Electrochemical Detection (GeneFluidics)
3.3.7 Single-Molecule Sequencing and Analysis (Nanofluidics)
3.3.8 Lab-on-a-Tape (Biotrove)
3.3.9 Nanoarrays (BioForce Nanosciences, NanoInk)
3.3.10 Dip Pen Nanolithography (NanoInk)
3.3.11 Nano Mass Spectrometry (Advion BioSciences)
3.3.12 NanoBreath (Nanotherapeutics)
3.3.13 NanoGrid (Biogenon)
3.4 Imaging
3.4.1 Quantum Dots
3.4.2 Nano-Trimetaspheres (Luna Innovations)
3.4.3 Dendrimers
3.4.4 Tumor-Specific Nanoparticles (Kereos, Nanospectra Biosciences)
3.5 Instruments
3.6 Market Analysis
4 Therapeutics and Drug Delivery
4.1 Role of Nanotechnology
4.1.1 Objectives and Advantages
4.2 Sustained Release
4.2.1 Medusa System (Flamel)
4.2.2 NanoGATE (iMEDD)
4.2.3 Nanodry, Nanocoat (Nanotherapeutics)
4.2.4 Fleximer (Nanopharma)
4.3 Solubility and Reformulation
4.3.1 IDD, DissoCubes, SLN (SkyePharma)
4.3.2 NanoEdge (Baxter)
4.3.3 NanoCrystal (Elan Nanosystems)
4.3.4 Precipitation With Compressed Antisolvent (CritiTech)
4.3.5 Evaporative Precipitation Into Aqueous Solution (Dow Chemical Co.)
4.3.6 High-Pressure Homogenization (PharmaSol)
4.3.7 Controlled Flow Cavitation (Five Star Technologies)
4.3.8 Transdermal Micellar Nanoparticles (Novavax and NanoCarrier)
4.3.9 Bioral Technology (BioDelivery Sciences)
4.3.10 PEGylated Nanoparticle Liposomes (ALZA)
4.3.11 Polyvalent Liposome Nanoparticles (LigoCyte)
4.3.12 BioVant Vaccine Adjuvant (BioSante)
4.4 Cancer Drugs With Modulated Targeting
4.4.1 NanoShells (Nanospectra Biosciences)
4.4.2 Magnetic Nanoparticles (Triton Biosystems vs. Nanobiotix)
4.5 Targeted Cancer Drugs Without Modulation
4.5.1 Colloidal Gold TNF Nanoparticles (CytImmune Sciences)
4.5.2 Atomic Nanogenerators (Dow Chemical Co., Sloan-Kettering)
4.5.3 Micellar Nanoparticles (NanoCarrier, GlaxoSmithKline, Kirin, CTT)
4.5.4 Lymph Node Drug Delivery (Nanopharma)
4.5.5 Nanocrystallization (Ntera)
4.6 CNS Delivery: Crossing the Blood-Brain Barrier
4.6.1 Nanocure (Advectus Life Sciences)
4.6.2 NANODEL (NanoPharm)
4.7 General Targeting
4.7.1 Dendrimers (Starpharma Pooled Development Fund)
4.7.2 Targesome
4.7.3 Poly Functional Nanoparticles (Alnis BioSciences)
4.8 Drug Delivery Implants
4.9 Nanomaterial Drugs
4.9.1 Antioxidant and Anti-HIV Fullerenes (C Sixty)
4.9.2 Antimicrobial Nanoemulsions (NanoBio)
4.9.3 Rx Nanocrystals (NUCRYST Pharmaceuticals)
4.9.4 RenaZorb (Altair Nanotechnologies)
4.9.5 Nanotube Drug Research
4.10 Market Analysis
5 Biomedical Implants and Biomaterials
5.1 Role of Nanotechnology
5.1.1 Objectives and Advantages
5.2 Surface Modification
5.3 Device Coatings
5.3.1 Bandages
5.3.2 Protective Coatings
5.3.3 Stents
5.4 Tissue Engineering and Orthopedics
5.4.1 NanoOss/Angstrom Medica
5.4.2 Nanobone and Bone Cement
5.4.3 Self-assembled Collagen Nanofibers
5.4.4 Tissue and Organ Regeneration
5.4.5 Wound Healing and Tissue Glues
5.4.6 Bioactive Scaffolds
5.4.7 Patterning and Nerve Growth
5.5 Other Devices
5.5.1 Novel Organ-assisting Devices
5.5.2 Brachytherapy
5.6 Market Analysis
6 Biomedical Research and Drug Discovery Tools
6.1 Role of Nanotechnology
6.1.1 Objectives and Advantages
6.2 Drug Discovery Tools
6.2.1 NanoMassSpectrometry
6.2.2 Nanoarrays
6.2.3 Nanolithography Arrays
6.2.4 Living Chip (BioTrove)
6.2.5 Congruent Force Intermolecular Test (Nanotype)
6.2.6 Computer-Assisted Drug Discovery
6.3 Biological Research
6.4 Liquid Handling
6.5 Separation and Filtration
6.5.1 Nanopore Sequencing and Separations
6.6 Market Analysis
7 Total World Market Summary
8 Future Applications: Nanoassembly and Beyond
8.1 Overview
8.2 Self-Assembly
8.3 Nanoassemblers
8.4 Cellular Interface and Implants
8.5 Nanobots
9 Company Briefs
9.1 Advion BioSciences Inc
9.2 Angstrom Medica Inc
9.3 BioForce Nanosciences, Inc
9.4 Biophan Technologies, Inc
9.5 C Sixty Inc
9.6 Elan Nanosystems
9.7 Flamel Technologies S.A
9.8 Invitrogen Corp
9.9 NanoInk, Inc
9.10 Nanoplex Technologies, Inc
9.11 Nanospectra Biosciences, Inc
9.12 NUCRYST Pharmaceuticals
10 Company Directory
List of Figures
Figure 3-1 World Market Size for Nanotechnology-based
Diagnostics 2005-2007
Figure 4-1 World Market Size for Nanotechnology-based
Therapeutics and Drug Delivery 2002-2007
Figure 4-2 World Market Size for Nanotechnology-based
Drug Therapeutics 2002-2007
Figure 4-3 World Market Size for Nanotechnology-based
Drug Delivery Services 2002-2007
Figure 5-1 World Market Size for Nanotechnology-based
Biomedical Implants and Biomaterials 2002-2007
Figure 6-1 World Market Size for Nanotechnology-based
Biomedical Research/Drug Discovery Tools 2002-2007
Figure 7-1 Total World Market Size for Biomedical Nanotechnology 2002-2007
