Rheumatology/Arthritis

Excessive immune response disorders such as arthritis result from a functional increase in the activity of the immune system. Autoimmunity and hypersensitivity are types of excessive immune response disorders. They are often related, and both may be present in patients with excessive immune responses. The cause of immune system overreactions is poorly understood. Interplay between genetic factors, particularly major histocompatibility (MHC) complex genes, and environmental factors are thought to be important in the development of autoimmune disorders.

Some evidence suggests that excessive immune responses may be due to glucocorticoid resistance in target tissues. For example, the number of glucocorticoid receptors in circulating leukocytes is decreased 50% in patients with RA. This decrease in receptors would prevent adequate suppression of leukocyte activity and could further enhance inflammation.Rheumatologists remain the most up-to-date health professionals in autoimmune disease treatment. Early intervention has been noted by nearly all in the field as the single most important factor in treatments and continued quality of life. New advancements in risk factors, diagnosis, and therapies have made it possible for rheumatologist to treat these conditions successfully with the best possible outcomes.

Successful treatment of autoimmune diseases have resulted from a growing array of therapies available to specialists. Symptomatic treatments have traditionally been used for patients with rheumatoid arthritis, lupus and other autoimmune disorders. While these treatments are still used regularly, new disease-modifying therapies have produced the most impressive results in treating these diseases. Additionally, combination therapies continue to grow in preference and offer exciting results in disease management.