Vaccine Production (Trends, Techniques, Key Players, Spending Estimates and Forecasts)


February 1, 2012
180 Pages - SKU: KLI6420063
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Vaccines are among the top revenue earners in recent years, and in some cases have assisted major pharmaceutical companies to revenue growth. But this is not without some trade-offs. Vaccines involve a complex production process. Is vaccine-making profitable? How much is the industry spending? How much is handed off to other companies and how much is made by the branded manufacturers? How many doses are produced by the industry? These are the type of questions that Kalorama Information has taken on in this report.

The considerable revenue growth in the vaccine market over the past ten years suggests the amount of vaccine production and the techniques of vaccine production will need to adapt to match a revived industry.

This report, Vaccine Production (Trends, Techniques, Key Players, Spending Estimates and Forecasts) examines the market for vaccine manufacturing and production technologies. The focus is on current production methods and new methods in development. While there may be some overlap for technologies in development, the emphasis of the report is process rather than product development. (Detailed product market segment forecast by disease for current vaccines are covered in Kalorama’s report “Vaccines 2011.” )

As part of its analysis of vaccine manufacturing, the report includes:

  • Doses Produced: 2010-2015
  • Estimates of Vaccine Production Spending
  • Finished Vaccine Markets and Top Selling Categories
  • Market Potential for Contract Vaccine Manufacturing
  • Top Vaccine Companies Market Share
  • Production Challenges for Categories of Vaccines
  • Discussion of Cell, Insect and Plant Production
  • Recent Influenza Production Trends
  • Vaccine Approval Challenges
  • Profiles of Major Vaccine Marketers
  • Profiles of Major Contract Manufacturers
  • Production Methods for Common Vaccines (Oral polio, Tetanus, Measles, Influenza, Diphtheria, Pertussis, BCG, Hep. B, Hib, MMR)
As part of Kalorama Information's coverage, several profiles are included of vaccine manufacturers and contract manufacturing organizations (CMOs). The following companies are profiled:
  • GlaxoSmithKline Biopharmaceuticals
  • Sanofi-Aventis
  • Merck KgaA
  • Pfizer-Pfizer CenterSource
  • Novartis AG
  • Baxter International
  • Teva
  • Crucell (Johnson &Johnson)
  • CSL Biotherapies
  • Intercell
  • MedImmune/Astra Zeneca
  • MassBioLogics
  • Lonza
  • Boehringer Ingelheim
  • Fujifilm Diosynth Biotechnology
  • Catalent Pharma Solutions
  • Patheon
  • DSM Pharmaceutical
  • Cambrex (Lonza)
  • IDT Biologika
  • Charles River Biopharmaceutical Services (BPS)
Sales estimates for the vaccine market and for market segment represent global revenues and are expressed in current dollars. Spending also represents global spending and expressed in current dollars.

Information for this report was gathered from a wide variety of published sources including company reports and filings, government documents, legal filings, trade journals, newspapers and business press, analysts’ reports and other sources. Interviews with company representatives and other experts were conducted to capture the perspectives from industry participants’ point of view and assess trends, and form the basis of the forecasting and competitive analysis.

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Additional Information

Growth of Vaccines Calls for Better, Faster Production

What a difference a decade has made in vaccines. According to a new market research report from healthcare publisher Kalorama Information, ten years ago the vaccine market was $5.7 billion dollars. Now, driven partially by the adult influenza vaccine market, and new brands such as Gardasil and Prevnar, the vaccine market has soared to over $27 billion. This kind of growth has strained vaccine production capacity and will drive new investment and innovation in this area. The firm published its findings in its recent report, Vaccine Production (Trends, Techniques, Key Players, Spending Estimates and Forecasts).

"It's an industry that needs to change production to match the demand," said Bruce Carlson, publisher of Kalorama Information. "The industry will continue to move from egg-based to cell-based, plant-based and insect-based production technologies."

Many adult and pediatric vaccines are produced by efficient cell-based technologies. Influenza uses a production system based on growing vaccines in chicken eggs, a technology that has been used since the middle of the last century. Novel vaccine production techniques are underway but the major technology is still egg-based. Flu vaccines are among the few that confer no long-term immunity and must be administered annually. A huge global effort is required each year by infectious disease monitoring organizations, biologics manufacturers, finish and fill suppliers, government regulatory agencies, distributors, and primary healthcare providers. These issues will become important, as production capacity is increasing. Kalorama indicates that the vaccine industry overall produced an estimated 23 billion doses in 2010, and demand should increase that number to 35 billion doses by 2015.

Kalorama also projects a small but growing opportunity for CMOs, contract manufacturing organizations who can help branded makers with clinical trial batches, new products where existing facilities won't cope, and increased pandemic demand.

"Quality control and tight regulation have made it so that, in most cases, vaccine companies do the manufacturing work themselves," said Carlson. "You don't see the outsourcing you do in other industries. However, there are some partnerships now and we expect more as makers cope with increased demand."

For more information, including estimates of industry vaccine production spending and profiles of vaccine makers and CMOs, see Kalorama's new report, Vaccine Production (Trends, Techniques, Key Players, Spending Estimates and Forecasts).


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