Chapter One: Executive Summary
- Introduction and Overview
- Definition and Scope
- Primary Osteoporosis
- Secondary Osteoporosis
- Risk Factors for Developing Osteoporosis
- Importance of Both Diagnostics and Therapeutics in the Management of Osteoporosis
- Evolution of Market Awareness and Market Dynamics
- Demographics as a Driving Force
- Osteoporosis Disease Management: Diagnostic and Therapeutic Products
- Osteoporosis Diagnostics
- Overview
- Densitometry
- Competitive Environment: Major Suppliers of Densitometers
- Biochemical Markers
- Bone Resorption
- Bone Formation
- Competitive Environment: Major Suppliers of Marker Assays
- Osteoporosis Diagnostics in Development
- Competitive Environment: Major Suppliers of Osteoporosis Diagnostics on the Market
- Osteoporosis Therapeutics
- Overview
- Product Categories
- Hormone Replacement Therapy
- Calcitonin
- Bisphosphonates
- Bone Formation Agents
- Fluorides
- Anabolic Steroids
- Calcium
- Vitamin D
- Osteoporosis Therapeutics in Development
- New Products
- Combination Therapy
- The Market
- Market Size (Revenue) and Forecast
- Issues and Trends
- Evolving Role of Key Market Constituents
- Patients
- Managed Care Organizations
- Physicians
- Pharmacies
- Insurance Companies
- Medicare Administration
- Women's Health Advocacy Organizations
- Increased Demand for Bone Density Tests
- Lack of Guidelines for Osteoporosis Screening
- Availability of Diagnostic Equipment
- Agreements Between Pharmaceutical and Diagnostic Companies
- Cost of Various Treatments for Osteoporosis
- Scope and Methodology
Chapter Two: Introduction to Osteoporosis
- Overview
- Bone Biology
- Osteoporosis Disease Management
- Overview
- Incidence and Prevalence
- Cost of Osteoporosis-Related Fractures
- Pathogenesis of Osteoporosis
- Primary Osteoporosis
- Secondary Osteoporosis
- Risk Factors for Developing Osteoporosis
- Genetic Factors
- Hormone-Related Factors
- Lifestyle-Related Factors
- Nutrition-Related Disorders
- Osteoporosis Diagnostics
- Overview
- Bone Densitometry
- Biochemical Markers
- Bone Resorption
- Osteoporosis Therapeutics
- Overview
- Antiresorptive Agents
- Hormone Replacement Therapy (HRT)
- Combined Hormone Replacement Products
- Calcitonin
- Bisphosphonates
- Bone Formation Agents
- Fluorides
- Anabolic Steroids
- Parathyroid Hormone
- Combination Therapy and Other Agents
- Combination Therapy
- Calcium
- Vitamin D
Chapter Three: Diagnostic and Therapeutic Products
- Osteoporosis Diagnostics: Product Overview
- Densitometry as a Diagnostic Tool
- Clinical Indications
- BMD Techniques
- Diagnostic Criteria and BMD Values
- Cost of Examinations
- Major Suppliers of Densitometers
- Biochemical Markers
- Major Suppliers of Marker Assays
- Perceptions of Biochemical Markers
- Osteoporosis Therapeutics
- Product Overview
- Bone Mass and Fracture Risk
- BMD Values and Therapeutics
- Osteoporosis Therapeutics For Men
- Calcium and Vitamin D Supplementation
- Efficacy
- Side Effects
- Contraindications
- Duration of Treatment
- Estrogen Replacement Therapy
- Efficacy
- Side Effects
- Contraindications
- Duration of Treatment
- Bisphosphonates
- Efficacy
- Side Effects
- Contraindications
- Duration of Treatment
- Calcitonin
- Efficacy
- Contraindications
- Duration of Treatment
- Other Off-Label Therapeutics
- Sodium Fluoride
- Anabolic Steroids
- Concomitant Use of Therapeutic Agents
- Cost of Various Treatments for Osteoporosis
- Osteoporosis Diagnostics and Therapeutics in Development
- Overview
- Osteoporosis Diagnostics in Development
- Ultrasound Densitometers
- Biochemical Markers
- Osteoporosis Therapeutics in Development
- Anti-Estrogen Therapeutics
- Parathryroid Hormone
- Sodium Fluoride
- Directions for Future Research
Chapter Four: Issues and Trends
- Managed Care
- Emphasis on Disease Prevention
- Impact on Osteoporosis
- Osteoporosis Screening
- Medicare and Managed Care
- Growing Enrollment in Managed Care
- Demographics
- Population of Elderly Continues to Increase
- Increase in Elderly Population Increases Number of Osteoporosis Fractures
- Increase in Elderly Population Increases Osteoporosis Costs
- Acute-Care Hospital Costs
- Long-Term Care Costs
- Research Essential To Determine Optimal Prevention and Effective Care Strategies
- Therapeutics Drive Demand for Bone Density Tests
- Relating Therapeutics to Diagnostics
- Availability of Diagnostic Equipment
- Interpreting Test Results: Performance Standards
- Agreements Between Pharmaceutical and Diagnostic Companies
- Merck Promotes Bone Density Examinations
- Suitability of Biochemical Markers in Managing Osteoporosis
- Hormone Replacement Therapy as a Prophylactic Against Osteoporosis
- The Compliance Issue
- National Focus On Women's Health
- Older Women
- Future Trends in the Management of Osteoporosis
- Ultrasound Diagnostic Densitometry
- Lunar's Achilles Ultrasound Densitometer
- Genome Science and Therapeutics
- Research Focuses on Gene-Based Drug Discovery
- SmithKline Beecham's Gene Discovery
- The Osteoporosis Gene (the VDR Gene)
Chapter Five: The Market
- Disease Management
- Scope and Methodology
- Demographics Driving Market
- Market Overview
- Total Market Size And Forecast
- Osteoporosis Diagnostics
- Biochemical Markers
- Market Size and Forecast
- Major Products and Competitors
- Trends
- Bone Densitometers
- Market Size and Forecast
- Major Products and Competitors
- Trends
- Osteoporosis Therapeutics
- Hormone Replacement Therapy
- Market Size and Forecast
- Major Products and Competitors
- Trends
- Non-hormonal Therapeutics
- Market Size and Forecast
- Major Products and Competitors
- Trends
Chapter Six: Company Profiles
- Overview of Diagnostics Manufacturers
- Overview of Therapeutics Manufacturers
- Abbott Laboratories
- History and Lines of Business
- Financial Information
- Analysis
- Osteoporosis Therapeutics
- Research and Development
- Corporate Strategies
- Ariad Pharmaceuticals, Inc.
- History and Lines of Business
- Financial Information
- Analysis
- Signal Transduction in Cells and Osteoporosis
- Bristol-Myers Squibb Co.
- History and Lines of Business
- Financial Information
- Analysis
- Osteoporosis Product
- Research and Development
- Hoffman-La Roche Inc.
- History and Lines of Business
- Financial Information
- Analysis
- Osteoporosis Therapeutic Product
- Research and Development
- Hologic, Inc.
- History and Lines of Business
- Financial Information
- Analysis
- Densitometry Products
- Research and Development
- Corporate Strategies
- Human Genome Sciences, Inc.
- History and Lines of Business
- Financial Information
- Analysis
- Gene Discovery and Osteoporosis
- Incyte Pharmaceuticals, Inc.
- History and Lines of Business
- Financial Information
- Analysis
- Gene Sequencing and Osteoporosis
- Ligand Pharmaceuticals, Inc.
- History and Lines of Business
- Financial Information
- Analysis
- Intracellular Receptor Technology and Osteoporosis Products
- Lunar Corp.
- History and Lines of Business
- Financial Information
- Analysis
- Bone Densitometry Products
- Research and Development
- Corporate Strategies
- Eli Lilly and Co.
- History and Lines of Business
- Financial Information
- Analysis
- Osteoporosis Therapeutics
- Merck & Co., Inc.
- Lines of Business
- Financial Information
- Analysis
- Osteoporosis Product
- Research and Development
- Corporate Strategies
- Metra Biosystems, Inc.
- History and Lines of Business
- Financial Information
- Analysis
- Osteoporosis Products
- Research and Development
- Corporation Strategies
- Norland Medical Systems, Inc.
- History and Lines of Business
- Financial Information
- Analysis
- Densitometry Products
- Research and Development
- Corporate Strategies
- Novartis, Ltd.
- Lines of Business
- Financial Information
- Analysis
- Osteoporosis Products
- Research and Development
- Ostex International, Inc.
- History and Lines of Business
- Financial Information
- Analysis
- Osteoporosis Product
- Research and Development
- Corporate Strategies
- Pharmacia & Upjohn Inc.
- History and Lines of Business
- Financial Information
- Corporate Analysis
- Osteoporosis Therapeutic
- Rhone-Poulenc Rorer Inc.
- History and Lines of Business
- Financial Information
- Analysis
- Osteoporosis Therapeutic
- Research and Development
- SmithKline Beecham Corp.
- History and Lines of Business
- Financial Information
- Analysis
- Osteoporosis Therapeutics
- Research and Development
- Unigene Laboratories Inc.
- History and Lines of Business
- Financial Information
- Analysis
- Osteoporosis Therapeutics
- Research and Development
- Warner-Lambert Co.
- History and Lines of Business
- Financial Information
- Analysis
- Osteoporosis Therapeutics
- Corporate Strategies
- Wyeth-Ayerst Laboratories (Division of American Home Products Corp.)
- History and Lines of Business
- Financial Information
- Analysis
- Osteoporosis Therapeutics
Appendix A: Glossary of Terms
Appendix B: Company Names and Addresses
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