Advances in Cancer Therapy

Chapter One

Executive Summary
Introduction
Scope And Methodology
Size And Growth Of The Market
Market Trends
The Nature Of The Industry
The New Technologies

Chapter Two

Introduction
• What Is Cancer?
• Who Gets Cancer?

Point Of View

Chapter Three

Cancer Epidemiology
Market Population Trends
• Variations In Global Cancer Incidence

Cancer Prevalence Trends
Cancer Incidence Trends

Chapter Four

Cancer Therapy Markets
Market Overview
• Antineoplastic Drugs
• Cytotoxic Drugs
• Hormonal Drugs
• Adjunctive/Side-Effect Management Drugs
• Hematopoietic Restoration
• Severe Pain Management
• Opportunistic Infection Control
• International Market Overview

Chapter Five

Current Therapeutic Approaches And Technology
• How Cancer Is Treated
• Sur
• Laser Surgery
• Electrosurgery
• Cryosurgery
• Radiation Therapy (Radiotherapy
• External Radiation Therapy
• Internal Radiation Therapy
• Chemotherapy
• Hormone Therapy
• Biological Therapy

Chapter Six

Advanced Cancer Therapeutics And The New Paradigm
• The New Paradigm
• Emerging Approaches To Cancer Therapy And Management: An Overview

Chapter Seven

Immunological And Vaccine Approaches
• The Technological Basis For Cancer Immunotherapy
• Cytokine Therapeutics
• Genetic Cytokine Stimulation
• Cancer Vaccines
• Modified Antibodies
• Alternative Approaches To Cancer Immunotherapy
• Progress In Cancer Immunotherapy
• Limitations Of Immune Therapy
• The Commercial Outlook

Chapter Eight

Antiproliferative Approaches
• Angiogenesis Regulators
• Angiogenic Regulators In Tumor Vascularization
• Progress In Angiogenesis Inhibitor Development
• The Commercial Outlook

Chapter Nine

Photodynamic Therapy
• Mechanism Of Action
• Photosensitizers
• The Benefits And Limitations Of Pdt
• Applications Of Pdt In Cancer
• The Commercial Outlook

Chapter Ten

Gene Therapy Approaches
• Gene Therapy: Barriers And Drivers
• The Technology Of Gene Therapy
• Physical Gene Insertion Approaches
• Direct Injection Of Genetic Material
• Microprojectile Injection
• Electroporation
• Lithotriptic Shock Wave Insertion
• Chemical Gene Insertion Approaches
• Chemical Transfection
• Lipofection
• Cytofection
• Liposomal Transfer
• Biological Gene Insertion Approaches
• Retrovirus Gene Vectors
• Adenoviral Gene Vectors
• Adeno-Associated Viruses (Aavs)
• Herpesvirus Gene Vectors (Hsv-1)
• Other Biological Vectors
• Artificial Chromosome Gene Vectors
• Ligand/Receptor Gene Vectors
• Types And Effects Of Therapeutic Genes
• Phenotype Alteration With Tumor Suppressor Genes
• Phenotype Alteration With Oncogenes
• Induction/Reduction Of Multidrug Resistance
• Induction Of Cellular Toxicity By Gene Transfer
• The Last Word In Gene Therapy
• The Commercial Outlook

Chapter Eleven

Cell Cycle And Apoptosis Approaches
• Apoptosis
• Inducing Apoptosis In Tumors
• Cell Cycle-Based Cancer Therapeutics
• The Commercial Outlook

Chapter Twelve

Company Profiles
Abgenix, Inc.
Agouron Pharmaceuticals, Inc
Amgen, Inc.
Biomira, Inc.
Bristol-Myers Squibb Co.
British Biotech Plc
Collagenex Pharmaceutics, Inc.
Corixa, Corp.
Dusa Pharmaceuticals, Inc.
Genta, Inc.
Genzyme Molecular Oncology
Isis Pharmaceuticals, Inc.
Morphosys Ag
Onxy Pharmaceuticals, Inc
Pharmacyclics, Inc
Ribozyme Pharmaceuticals, Inc
Sugen, Inc
Vical, Inc.
Competitive Summary

Chapter Thirteen

Conclusions And Strategic Implications
• First Conclusion
• Implications
• Second Conclusion
• Implications
• Third Conclusion
• Implications
• Fourth Conclusion
• Implications
• Fifth Conclusion
• Implications
• Sixth Conclusion
• Implications
• Seventh Conclusion
• Implications
• Eighth Conclusion
• Implications
• Ninth Conclusion
• Implications
• Tenth Conclusion
• Implications
• Eleventh Conclusion
• Implications
• Twelfth Conclusion
• Implications
• Thirteenth Conclusion
• Implications
• Fourteenth Conclusion
• Implications

Appendix A

Glossary

Appendix B

Company Names And Addresses

List of Exhibits

Chapter One: Executive Summary
Table 1-1: The Size Of Cancer Therapeutic Markets In The Seven Major World Healthcare Markets: 1998-2006 (Us$ Billions)
Figure 1-1: The Size Of Cancer Therapeutic Markets In The Seven Major World Healthcare Markets: 1998-2006
Figure 1-2: Distribution By Segment Of Cancer Therapeutics Markets: 2000
Chapter Three: Cancer Epidemiology
Table 3-1: Populations Of The Major World Healthcare Markets: 1998 - 2006 (Millions)
Figure 3-1: Trends In The Populations Of The Major World Healthcare Markets: 1998 - 2006 (Millions)
Table 3-2: Estimated Cancer Prevalence In The Major World Healthcare Markets: 1998 - 2000 (Millions)
Figure 3-2: Trends In The Cancer Prevalence Rates For The World's Major Healthcare Markets: 1998 - 2006 (Patients Per 100,000 Population)
Table 3-3: Estimated Incidence (New Cases) Of Selected Cancers In The World's Major Healthcare Markets: 2000 (Thousands)
Figure 3-3: Distribution Of Major Cancer Incidences In The Seven Major World Healthcare Markets:2000
Chapter Four: Cancer Therapy Markets
Figure 4-1: Growth In The Cancer Therapeutics Markets For The Seven Major World Healthcare Markets: 1998 - 2006 (Us$ Billions)
Table 4-1: Historic And Forecast Market Size For Cancer Therapeutics In The Seven Major World Healthcare Markets: 1998 - 2006 (Us$ Billions)
Figure 4-2: Historic And Future Growth In Antineoplastic Drug Sales In The Seven Major World Healthcare Markets: 1998 - 2006
Figure 4-3: Historic And Future Growth In Adjunctive And Side-Effect Management Drug Sales In The Seven Major World Healthcare Markets: 1998 - 2006 (Billions)
Table 4-2: Historic And Forecast Market Size For Cancer Therapeutics In The Seven Major World Healthcare Markets By Region: 1998 - 2006 (Us$ Billions)
Figure 4-4: Historic And Future Growth In Regional Cancer Therapeutic Drug Sales In The Seven Major World Healthcare Markets: 1998 - 2006 (Billions)
Chapter Five: Current Therapeutic Approaches And Technology
Table 5-1: Therapeutic Options In The Treatment Of Cancer
Table 5-2: Commonly Used Chemotherapeutics For Specific Cancers
Table 5-3: Commonly Used Hormone Therapeutics For Specific Cancers
Chapter Six: Advanced Cancer Therapeutics And The New Paradigm
Figure 6-1: Cancer Patient Survival As A Function Of Therapeutic Mode
Table 6-1: Emerging Cancer Therapies
Table 6-2: Comparison Of Emerging Cancer Therapies
Table 6-3: Emerging Cancer Therapies: Developmental Risks
Figure 6-2: Timeline For Advanced Cancer Therapeutic Development
Table 6-4: Estimated Peak Market Potentials For Advanced Cancer Therapeutics (Us$ Millions)
Chapter Seven: Immunological And Vaccine Approaches
Table 7-1: Cytokines And Growth Factors That Influence The Immune System In Cancer Patients
Table 7-2: Immune Response-Enhancing Herbs
Table 7-3: Active Clinical Trials Involving Cancer Immunotherapy
Chapter Eight: Antiproliferative Approaches
Table 8-1: Endogenous Angiogenesis Regulators
Table 8-2: Key Angiongenesis Inhibitors In Development
Table 8-3: Active Clinical Trials Involving Antiangiogenesis In Cancer Therapy
Chapter Nine: Photodynamic Therapy
Table 9-1: Photosensitizers In Application With Cancer Photodynamic Therapy
Table 9-2: Active Clinical Trials Involving Photodynamic Therapy For Cancer
Chapter Ten: Gene Therapy Approaches
Table 10-1: Physical Gene Transfer Technologies
Table 10-2: Chemically Assisted Gene Transfer Technologies
Table 10-3: Viral Vector Gene Transfer Technologies
Table 10-4: Active Clinical Trials Involving Genetic Therapy For Cancer
Chapter Eleven: Cell Cycle And Apoptosis Approaches
Table 11-1: Representative Chemotherapeutic Agents Employed On The Basis Of Cell Cycle Selectivity
Table 11-2: Cell Cycle Regulators
Table 11-3: Cell Cycle Regulators By Phase