In the past two decades, drug delivery has become a major factor in the advancement of the quality of life and a key factor in the business success of pharmaceutical companies. During this time, syringes and injectors have evolved considerable to address the changing demands of clinicians and their patients. In particular, the appearance and refinement of disposable drug cartridges has created unique opportunities for developers of injectable drugs. Prefilled cartridges offer several advantages over traditional packaging in vials. For single dose devices, prefilled cartridges contain the exact deliverable dose desired. The custom of overfilling vials to insure availability of the desired dose allows for the possibility of dosing errors that are eliminated with cartridge systems. For recombinant drugs that have an extremely high cost per dose, the economics associated with exact filling are compelling.