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This Report provides an up-to-date, comprehensive analysis of the tissue engineering industry. The Report presents an analysis of core tissue engineering technology (cells, materials, and manufacturing) and evaluates both the technical and market challenges and opportunities. In addition, the Report provides a clear understanding of the complexities of product development, the potential impact of new technical advances, and the necessary context for business planning. This Report provides the critical knowledge necessary to succeed in this developing market.
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Chapter 1: Executive Summary
Chapter 2: Introduction
- Scope of Report
- Objectives
- Format
- Sources of Information
- Forecasts
- Definitions
- Exhibits
Chapter 3: Tissue Engineering: Progress and Promises
- Lessons Learned
- Going Forward
Chapter 4: Critical Components
- Cell Source
- Types of Cellular Material
- The Promise of Stem Cells
- Embryonic Stem Cells
- Adult Stem Cells
- Regulatory and Safety Issues
- Biomaterials, Matrices, and Scaffolds
- Importance of ECM
- Types of Materials
- Future Trends
- Use of Growth Factors
- Exploiting Self-Assembly
- Combinatorial Material Arrays
- Safety and Regulatory Issues
- Architecture
- Promoting Vascularization
- Manufacturing
- Three-dimensional Cell Culture
- Scale-up
Chapter 5: Applications
- Structural Tissue Engineering
- Skin
- Bone
- Cartilage
- Connective Tissue
- Muscle (non-cardiac)
- Organ Tissue Engineering
- Pancreas
- Liver
- Neural
- Cardiovascular
Chapter 6: Market Dynamics
- The Healthcare Environment
- Cost Containment
- Aging Population
- Pharmaceutical R&D Costs Rising
- Regulatory
- Specific Regulations for Tissue Engineered Products
- General Device Regulation
- Drug/Biological Product Approval
- Market Dynamics
- Burn and Wound Healing
- Demand Factors
- Barriers to Entry
- Commercialization Issues
- Competition
- Market Size
- Bone, Cartilage and Connective Tissue
- Demand Factors
- Barriers to Entry
- Commercialization Issues
- Competition
- Market Size
- Organ Repair and Replacement
- Demand Factors
- Barriers to Entry
- Commercialization Issues
- Competition
- Market Size
Chapter 7: Company Profiles
- 3DM, Inc.
- Acorda Therapeutics
- Advanced Cell Technology
- BioTissue Technologie GmbH
- Dentigenix, Inc.
- FibroGen
- Genzyme Biosurgery
- Geron Corporation
- Intercytex Limited
- Integra LifeSciences Holding Corporation
- Isotis OrthoBiologics
- Islet Sheet Medical LLC
- LifeCell Corporation
- NeuColl, Inc
- Novocell, Inc
- Ortec International, Inc
- Osiris Therapeutics, Inc
- OsteoBiologics, Inc
- Osteotech, Inc.
- ReGen Biologics, Inc.
- Selective Genetics, Inc.
- Smith & Nephew
- StemCells, Inc.
- TEI Biosciences, Inc
- Tepha, Inc
TABLE OF EXHIBITS
- Exhibit 1.1 Market for Tissue Engineered Products, 2002-2008 (thousands)
- Exhibit 4.1 Types of Stem Cells
- Exhibit 4.2 Human Embryonic Stem Cell Registry Companies with Available Cell Lines
- Exhibit 4.3 Collagen Types, Location and Characteristics
- Exhibit 4.4 Properties of Glycoaminoglycans
- Exhibit 4.5 Peptide Analogs to ECM Molecules
- Exhibit 4.6 Representative Biomaterials Used In Tissue Engineering
- Exhibit 4.7 Conventional Methods of Producing Scaffolds
- Exhibit 4.8 Angiogenesis Process
- Exhibit 4.9 Bioreactors Used in Tissue Engineering
- Exhibit 6.1 US Healthcare Spending—2002
- Exhibit 6.2 Percentage of Population Age 65 and Older, 2000-2020
- Exhibit 6.3 R&D Spending and New Product Approvals
- Exhibit 6.4 US Pharmaceutical R&D Spending By Application Area (2002)
- Exhibit 6.5 World Pharmaceutical Spending By Country (2001)
- Exhibit 6.6 Burns and Skin Ulcers—US, 2002
- Exhibit 6.7 Market for Tissue Engineered Burn and Wound Healing Products
- Exhibit 6.8 Bone, Cartilage, and Connective Tissue Procedures
- Exhibit 6.9 Market for Tissue Engineered Bone, Cartilage and Connective Tissue
- Repair Products (thousands)
- Exhibit 6.10 Number of Patients Waiting for Organ Transplants, US—2002
- Exhibit 6.11 Number of Organ Transplants, US—2002
- Exhibit 6.12 Average Yearly Expenses for Spinal Cord Injury Patient (In 2000 Dollars)
- Exhibit 6.13 Market of Tissue Engineered Organ Repair and Replacement Products
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