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Solving Drug Discovery with Metabolomics and Metabonomics: New Aspects of the “Omic” Revolution

Drug and Market Development Publishing
February 1, 2005
245 Pages - SKU: DSMD1087158

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Solving Drug Discovery with Metabolomics and Metabonomics: New Aspects of the “Omic” Revolution

This Report will analyze the biochemical nature of metabolomics, the technologies behind metabolomics, metabonomics related approaches, and the appropriate market potentials. This Report highlights new developments in chemical network (biochemical pathways) technology and the analytical tools developed to facilitate drug discovery. The Report provides market trends and evaluates metabolonomic pertaining to the pharmaceutical industry and the potential of being applied in the areas of drug discovery and development, and preventive screening/diagnostics. In addition, this Report indicates target compound analysis by discussing methods that measure the quantification of specific metabolites. Profiles of the major players in the metabolomics/metabonomics and systems biology field are also included.

Chapter 1: Executive Summary

Chapter 2: Definitions and Models: Metabolomics and Metabonomics; The Metabolome; Beyond the Genome and the Proteome; Metabolomics and Plants; Metabonomics Needs Biologists, Computer Scientists, Chemists, Engineers, Mathematicians, and Physicists; Mammal-Microbe-Xenobiotic Systems’ Interactions; Pattern Recognition Methodologies; Global Metabolomic Analysis-Metabolomic Vector Analysis; Predictive and Preventive Medicine; Related “Omic” Disciplines and Drug Discovery Platforms; Lipomics and Glycomics; References
Chapter 3: Bioinformatics-Databases and Software: Databases for Metabolic Pathway Analysis; Data Mining; Chemometrics; University of Minnesota Biocatalysis/Biodegradation Database (UM-BBD); Leading Database Resources; Databases Associated with Genomics and Proteomics; Software for Metabolic Pathway Analysis; Artificial Neural Nets (ANN); References
Chapter 4: Techniques in Metabolomics and Metabonomics: Analytical Techniques; Overview of Spectroscopic Techniques; Analysis of Fingerprinting Methods; LC/NMR; Gas Chromatography (GC); High Performance Liquid Chromatography (HPLC); Lab-on-a-Chip; Capillary Electrophoresis (CE)/MS of Plants; Conclusions Technological overview of Spectroscopic Methodologies
Chapter 5: Metabolomics and Metabonomics: Markets, Applications, and Current Research: Market Value; Innovative Enhancements to the MS Technologies; SWOT Analysis for Metabolomic Technologies; Applications and Research; Main Metabolomic and Metabonomic Application Categories; Genomics to Metabolomics; Target Identification and Diagnostic Biomarkers; Personalized Medicine and Nutrition; Current Research on Pathway Analysis; Future Directions
Chapter 6: Company Profiles: Taxicogenomics-Icora (formerly Paradigm Genetics), Morphochem Inc; Chemogenomics-Acadia Pharmaceuticals, Amorpha Discovery Corp, Neogenesis Pharmaceuticals, Vertex Pharmaceuticals; Ribonomics-Biolog, Intradigm Corp., Ribonomics Inc, Sequitur; Phenomics-Mitokor Inc, Cellular Genomics Inc, Phenomenome Discoveries Inc, Organon; Target Identification-Metabolon Inc, High Chem Ltd., Metabometrix, GeneGo; COMET Network, Vion Pharmaceuticals, Pfizer; PhysioLab Entelos; Acadia Pharmaceuticals; Accelyrs Inc; Agilent Technologies, Inc; Bruker BioSciences Corp; Caliper Life Sciences; Icoria, Inc. (Paradigm Genetics); Sequenom
TABLE OF EXHIBITS: Exhibit 2.1 The Omics Industry; Exhibit 2.2 Roche’s Chemical Pathways Chart; Exhibit 2.3 Complexity of the Metabolome; Exhibit 2.4 Characteristic Metabolomics Signature Spectra; Exhibit 2.5 Principle Component Analysis of Two Phenotypes: Correlation of Proteome to Metabolome; Exhibit 2.6 Mammal-Microbe-Xenobiotic Systems’ Interactions; Exhibit 2.7 Sequence of Major Endogenous and Sym-xenobiotic after Colonization of Gut Microfloral Constituencies; Exhibit 2.8 Pachinko Metabolism Model; Exhibit 2.9 Metabolic Vector Analysis; Exhibit 2.10 Epigenetic Feedback Control of Protein Expression and Metabolic Profiles; Exhibit 2.11 Network Array Demonstrating the Connectivity of the Proteome to Metabolic Energy; Exhibit 2.12 Lipomics: Early Biochemical Steps of Cholesterol Synthesis; Exhibit 2.13 Galactose Metabolic System (“Glycome”); Exhibit 2.14 Pearson Correlation Map of Metabolites; Exhibit 3.1 Screen View of KEGG Start Up; Exhibit 3.2 Fatty Acid Metabolism; Exhibit 3.3 Pathways Determined by UM-BBD Databases; Exhibit 3.4 Compounds and Reactions Page for the (+)-Camphor Pathway; Exhibit 3.5 Pathway of Cyanuric Acid Degradation; Exhibit 3.6 PathDB Software Depiction; Exhibit 4.1 Schematics of Commonly Used Metabolomic Techniques; Exhibit 4.2 Desorption/Ionization On Porous Silicon Mass Spectroscopy; Exhibit 4.3 MS Spectra for Separate HPLC Peaks of MeTFMA Metabolites; Exhibit 4.4 Glycosylation Mapping by CE/MS Data; Exhibit 4.5 MS/MS Fingerprinting; Exhibit 4.6 Characteristic Mass Spectra of Fatty Acids; Exhibit 4.7 HTS LC-MS Column and Solvent Selection Valves; Exhibit 4.8 NMR Techniques in Biomedicine; Exhibit 4.9 E. coli Peptides Analyzed by 2DGE-LC-MS; Exhibit 4.10 Chinese Herbal Preparation Extracts; Exhibit 4.11 Drug Enantiomer Chiral Selection after CE; Exhibit 5.1 Market Forecast of Bio Tools; Exhibit 5.2 SWOT analysis for Metabolomic Industries; Exhibit 5.3 From Genome to Metabolome; Exhibit 5.4 Human Metabolome Profile; Exhibit 5.5 The Interplay of the Metabolome and the Genome; Exhibit 5.6 1H NMR Spectra of Different Rat Tissues; Exhibit 6.1 Metabolomic Profiles in Drug Discovery; Exhibit 6.2 Mass Distribution of Metabolomic Products; Exhibit 6.3 Metabolomic Comparison of Control (upper panel) and Autistic Children Plasma; Exhibit 6.4 NADH Biosynthetic Pathway; Exhibit 6.5 Network Around Drug-metabolizing Enzyme CYP3A4; Exhibit 6.6 From NCE to Pathways

Solving Drug Discovery with Metabolomics and Metabonomics: New Aspects of the “Omic” Revolution

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