D&MD’s Ion Channels and G-Protein Coupled Receptors (GPCRs): Industry Report on Pharmaceutically-Relevant Target Classes identifies qualitative trends—market drivers, market challenges, bottlenecks, opportunities—in each market segment. The report also provides quantitative analysis including market size, market shares of the various companies/technologies, and a cost per assay point, screening metrics. In addition, data from a proprietary end-user survey conducted by D&MD assesses market opportunities. The raw data and annotations of these data are presented in this industry report and provide a snapshot into the direction of this market.
About the Author:
Dr. Enal Razvi is currently biotechnology business development consultant based in the San Francisco Bay Area. In this capacity, Dr. Razvi analyzes a number of different market spaces in biotechnology, and assists start-up companies in business development, sales, marketing, and commercialization operations in the San Francisco Bay Area. Previously, Dr. Razvi served as Vice President of Business Development at DiscoveRx Corporation in Fremont, California. Before DiscoveRx, at LJL BioSystems (Sunnyvale, CA), Dr. Razvi served as Senior Director of Business Development and played a major role in developing LJL BioSystems' SNP genotyping business. Subsequent to the acquisition of LJL BioSystems by Molecular Devices Corporation, Dr. Razvi ran Molecular Devices' Genomics business. Prior to LJL, while at Frost & Sullivan, Dr. Razvi served as Director of their Drug Discovery Consulting business. Dr. Razvi holds a doctorate in biomedical sciences from the University of Massachusetts Medical School, and completed post-doctoral work at The Rockefeller University in New York and at Harvard Medical School.
This report is focused upon an analysis of the two pharmaceutically-important drug target classes—ion channels and G protein-coupled receptors (GPCRs). The following will be presented within this report:
- Classification and structure of ion channels and GPCRs.
- Signal transduction cascades initiated by ligand binding/stimulation of these targets.
- Technologies for interrogation of these target classes, opportunities, and challenges therein.
- The major products commercially available for interrogating these target classes.
- Market shares of vendors in the respective spaces.
- Qualitative and quantitative market analysis: market drivers, challenges, market size, growth rate, and future market opportunity.
- SWOT analysis of the various companies in the two market segments.
- Market size and business opportunities in the ion channel and GPCR spaces.
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- Chapter 1: Executive Summary
- Scope of this Report
- GPCRs and Ion Channels Target Space
- Snapshot of the Current GPCR Space
- Market Drivers, Challenges, and Opportunities Affecting Ion Channels and GPCRs
- Ion Channels
- GPCRs
- Ranking of Important Research Topics in the GPCR Space for Pharmaceutical
- Industry Researchers versus Academic Researchers
- Chapter 2: Market Analysis of Ion Channels
- Scope of this Chapter
- Introduction
- Price per Data Point for the Various Ion Channel Segments
- Ion Channel Interrogation Capital Equipment and Consumable Budgets
- Market Size for Ion Channel Instrumentation: 2006, 2007, and 2008
- hERG Liability Screening Market Metrics
- Types of Ion Channels Being Studied
- Ligand-Gated Ion Channels
- Voltage-Gated Ion Channels
- Fee-for-Service Business Model in the Ion Channels Space
- Segments in the Ion Channels Space That Offer Growth Opportunities
- Chapter 3: G Protein-coupled Receptors (GPCRs): Qualitative and Quantitative Market Analyses
- Scope of this Chapter
- Introduction to the Space
- Market Analysis: GPCR Analysis and Interrogation
- R&D Efforts Directed at GPCR Subclasses and The Various GPCR
- Interrogation/Analysis Technologies
- Size of GPCR Interrogation/Analysis Screening Campaigns
- Qualitative Impressions of the GPCR Marketplace, Trends Therein, and Open Questions
- Side Bar: Subclass-based GPCR Market Segmentation
- Chapter 4: Ion Channels: Classification & Structure Technologies for Interrogation
- Scope of This Chapter
- Chapter 5: G Protein-coupled Receptors (GPCRs): Classification & Structure Receptor-mediated Signaling Technologies for Interrogation
- Scope of This Chapter
- Chapter 6: GPCR and Ion Channel Classes: An End-user Survey of Growth Opportunities, Market Trends, and Quantitative Analyses
- Survey Methodology
- TABLE OF EXHIBITS
- Exhibit 1.1 Number and Percentage of GPCRs and Ion Channels in the Human Genome
- Exhibit 1.2 Ranking of Pharma Industry Researchers versus Academic Researchers ofDifferent Topics in the GPCR Space
- Exhibit 2.1 Ion Channel Interrogation Technologies and the Market Segments that theyAddress
- Exhibit 2.2 Penetrance of the Various APC Platforms in Ion Channel R&D—APC InstrumentMarket Share in terms of Ion Channel R&D
- Exhibit 2.3 Price per Data Point in the Various Ion Channel Market Segments
- Exhibit 2.4 Capital Equipment and Consumable Budgets for Ion Channel R&D
- Exhibit 2.5 Automated Patch Clamp (APC) Global Market Opportunity
- Exhibit 2.6 Global Market Opportunity for APC Sales
- Exhibit 2.7 In-house versus Outsourced hERG Liability Screening
- Exhibit 2.8 Market Model Describing the Market Opportunity for hERG LiabilityScreening
- Exhibit 2.9 The Various Types of Ion Channels
- Exhibit 2.10 Ion Channels Usage Pattern in the Marketplace
- Exhibit 2.11 Ranking of the Various Fee-for-service Vendors for Ion ChannelScreening and Interrogation
- Exhibit 3.1 Growth of the GPCR Interrogation/analysis Marketplace
- Exhibit 3.2 Facilities conducting GPCR R&D Per Institution
- Exhibit 3.3 Monthly Research Spending Interrogating/Analyzing GPCRs
- Exhibit 3.4 Percentage of R&D Efforts Directed at Different GPCR Subclasses bythe Total Respondent Pool
- Exhibit 3.5 Percentage of R&D Efforts Using Different GPCR Assay Methodologiesby the Total Respondent Pool
- Exhibit 3.6 Percentage of R&D Efforts Using Different GPCR Assay MethodologiesResolved into Pharmaceutical Company and Biotechnology CompanyParticipants—Illustrates Differences in R&D Trends in TheseMarket Segments
- Exhibit 3.7 Trend: Growth or Decline of the Various GPCR Assay/InterrogationApproaches
- Exhibit 3.8 Market Shares: Companies Offering Products in the Various GPCRInterrogation/Analysis Spaces
- Exhibit 3.9 Summary of Market Shares across the GPCR Interrogation/AnalysisLandscape
- Exhibit 3.10 Number of Experiments Run by Pharmaceutical Participants versusBiotechnology Participants in terms of interrogating/analyzing GPCRs
- Exhibit 3.11 Distribution of Experiments Run by Pharmaceutical Participants versusBiotechnology Participants in terms of Interrogating/analyzing GPCRs
- Exhibit 3.12 Market Size for GPCR Interrogation/Analysis in Terms of IndustryDollars and Experiments (Assays)
- Exhibit 3.13 Segmentation of GPCR Market Opportunity
- Exhibit 4.1 Classification of Ion Channels
- Exhibit 4.2 Voltage-gated Ion Channel: Activation States
- Exhibit 4.3 Ligand-gated Ion Channel: Structure and Activation States
- Exhibit 4.4 Calcium Channel Structure
- Exhibit 4.5 Schematic Representation of the HCN Channel
- Exhibit 4.6 6-TM Potassium Channel Structure
- Exhibit 4.7 Sodium Channel Structure
- Exhibit 4.8 Technologies for Ion Channel Interrogation I
- Exhibit 4.9 Technologies for Ion Channel Interrogation II
- Exhibit 4.10 Sequence of Methods for Studying Ion Channels
- Exhibit 4.11 Technologies for Ion Channel Interrogation
- Exhibit 4.12 Features/Advantages of the Patch Clamp Assay
- Exhibit 4.13 Automated Patch Clamping (APC) Products from the Various Vendors
- Exhibit 4.14 Fluorescence Measurement on FLIPR: An Alternate Approach forCa2+ Channels
- Exhibit 4.15 Luminescence on Flash Luminometer: Another Approach for Ca2+ Channels
- Exhibit 4.16 Principle of Rb+ -efflux Assay: Another Ion Channel Screening Assay
- Exhibit 4.17 Summary of Mainstream Technologies for Ion Channel Interrogation
- Exhibit 4.18 Summary of Technologies for Ion Channel Interrogation
- Exhibit 5.1 G Protein-coupled Receptors (GPCRs)
- Exhibit 5.2 A VERY Wide Variety of Ligands In Vivo Use GPRCs
- Exhibit 5.3 GPCRs I
- Exhibit 5.4 GPCRs II
- Exhibit 5.5 GPCRs Activate a Number of Signaling Cascades In Vivo
- Exhibit 5.6 GPCRs Schematic of Signaling Events
- Exhibit 5.7 Schematic of GPCR Stimulation with Various Physiological Ligands
- Exhibit 5.8 Different G Proteins for Different Responses to Ligands
- Exhibit 5.9 Different Cell Types Elicit Different Responses upon GPCR Stimulation
- Exhibit 5.10 Hoe do GPCRs Select G Protein(s) by which to Signal In Vivo?
- Exhibit 5.11 Summary: GPCR Signaling Cascades I
- Exhibit 5.12 Summary: GPCR Signaling Cascades II
- Exhibit 5.13 Mainstream Technologies for Interrogation of GPCRs
- Exhibit 5.14 Ligand-binding Assays
- Exhibit 5.15 GTP-binding Assays
- Exhibit 5.16 Time-resolved Fluorescence (TR-FRET)
- Exhibit 5.17 Agonists and Inverse Agonists of GPCR-mediated Signaling:Useful Reagents in GPCR Assays
- Exhibit 5.18 Assays for Downstream Signaling Events
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