What Strategies Will Yield Novel Treatments for Autoimmune Disease?
Decision Resources
March 14, 2008 26 Pages - SKU: DECR1725910
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More than 80 autoimmune disorders have been identified, all involving aberrant immune responses to self-antigens.
The emergence of biologic agents, such as the interferons and the TNF-รก inhibitors, has greatly improved
the treatment outlook for some of the more common autoimmune diseases. These agents have significant drawbacks,
however, including side effects and high costs. Pharmaceutical companies large and small have already
begun to focus their efforts on the molecular events that trigger autoimmunity, a discovery process that, it is
hoped, will reveal new drug targets that suppress undesired autoimmune infl ammatory responses in some of the
most common diseases.
Get the Answers You Need to Shape Your Strategy
- Understanding the etiology of the different autoimmune diseases will allow more successful diagno-
sis and treatment options. How will the identification of genetic markers help to create new diagnostic
tools? Will these tools offer a greater chance for successful treatment, or even a cure?
- Biologic agents have greatly improved the treatment of many autoimmune diseases, but these agents
are expensive and carry the risk of significant side effects. What new methods are being studied
as both treatments and curatives?
- Earlier identification of autoimmune diseases could greatly improve the quality of life for patients.
What's in store for the future of autoimmune R&D? What companies already have trials
under way?
Scope
- Pathophysiology and etiology: autoimmune disease is caused by antibodies that attack normal tissue;
the diseases can be organ-specific or systemic; most autoimmune diseases are caused by genetic
and/or environmental factors.
- Epidemiology: 2-8% of the U.S. population has some type of autoimmune disease, and the prevalence
of these diseases is increasing.
- Novel approaches to treatment: targeted biologics, new cell technologies, and novel treatment
methods are the focus of current drug discovery programs.
- Unmet need creates opportunity for new therapies: interferon-beta (for MS) and the TNF-alpha
inhibitors offer significant benefit over more traditional corticosteroid and DMARD treatments.
- Potential curative therapies on the horizon: cell therapies like stem cell replacement and tolerization
vaccines represent potential for cures.
Please note, the PDF e-mail from publisher version of this report is for a global site license.
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- Executive Summary
- Strategic Considerations
- Introduction
- Overview of Autoimmune Diseases
- Pathophysiology and Etiology
- Epidemiology
- Novel Targets and New Approaches to Treating Autoimmune Disease
- Novel Targets
- Sphingosine-1-Phosphate Receptor Modulators
- Janus Kinases
- Matrix Metalloproteinases
- Tolerance Induction
- PDE Inhibitors
- Novel Treatment Methods
- Antisense
- Hematopoietic Stem Cell Transplant
- Cell Therapy for the Treatment of Type 1 Diabetes
- New Approaches to Drug-Target and Biomarker Discovery for Autoimmune Diseases
- Genetic Analysis
- Proteomics: Mass Spectrometry, Protein and Antibody Arrays
- Mass Spectrometry
- Microarrays
- Flow Cytometry
- Lipidomics
- Imaging
- Company Profiles
- Alba Therapeutic
- Bayhill Therapeutics
- BioSeek
- MultiCell Technologies
- Novocell
- Osiris Therapeutics
- Osprey Pharmaceuticals
- Outlook
- Ongoing Unmet Need Creates Opportunity
- Potential Curative Therapies on the Horizon
- Other Future Yields of Today’s Autoimmune R&D
- Tables:
- 1. Overview of Select Autoimmune Diseases
- 2. Select Drug Classes Used to Treat Autoimmune Diseases
- 3. Select Novel Targets for the Treatment of Autoimmune Disease
- 4. Select Novel Approaches to Autoimmune Therapy
- 5. Select Companies Investigating Autoimmune Disease, 2008
- Figures:
- 1. Prevalent Cases of Select Autoimmune Diseases in the United States, 2007
- 2. Sites of Action of Current and Experimental Immunosuppressive Agents
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