How Insulin Resistance Diagnostics Can Expand the Market for Insulin-Sensitizing Agents
Decision Resources
October 23, 2007 28 Pages - SKU: DECR1762178
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Insulin resistance is a highly prevalent metabolic condition fraught with unmet need. Although several diagnostics
are in use, not one is ideal; a standardized, simple tool for measuring IR in clinical practice is needed. Novel
technologies have the potential to create widespread testing for IR in clinical settings, which would enable early
diagnosis and treatment of prediabetic patients.
Get the Answers You Need to Shape Your Strategy
- Insulin resistance has been tied to many other conditions, including diabetes, heart attacks, and dyslipidemia.
What are the benefi ts of early insulin resistance diagnosis?
- Several IR tests are used in experimental settings but not widely in clinical practice. What are the shortcomings
of the current tests and what are clinicians looking for in an IR test?
- Several indexes and tests are used to measure IR, and there is no standard test used in clinical practice.
What are the most common diagnostics used? Which companies are working toward creating new
diagnostics?
- Diagnostic tests that enable earlier detection and therapeutic intervention for IR may help to delay or prevent
the onset of type 2 diabetes and other diseases. What is the outlook for the current and novel IR diagnostics
and what is their commercial potential?
Scope
- Overview and unmet needs of insulin resistance : defi nition of IR and metabolic syndrome; unmet
need in IR testing; link between IR and other diseases.
- Epidemiology of insulin resistance : prevalence estimates of IR in the United States and Europe.
- Current IR diagnostics : Euglycemic hyperinsulinemic clamp, steady-state plasma glucose, fasting
plasma glucose, oral glucose tolerance test, and others.
- New diagnostics and key players : KineMed's KineMarkers, Isotechnika's Diatest, LipoScience's
NMR LipoProfi le, Entelos's Metabolism PhysioLab.
- Outlook and commercial potential : prospects of current and future diagnostic techniques meeting
the unmet need of IR testing.
Please note, the PDF e-mail from publisher version of this report is for a global site license.
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- Executive Summary
- Strategic Considerations
- Stakeholder Implications
- Unmet Need in Insulin Resistance Testing
- An Overview of Insulin Resistance
- Link Between Insulin Resistance and Other Diseases
- Epidemiology of Insulin Resistance
- Current Diagnostics for Insulin Resistance
- Euglycemic Hyperinsulinemic Clamp
- Steady-State Plasma Glucose
- Random Plasma Glucose
- Fasting Plasma Glucose
- Oral Glucose Tolerance Test
- Frequently Sampled Intravenous Glucose Tolerance Test
- Glycosylated Hemoglobin A1c
- Fasting Insulin Measurements
- Homeostasis Assessment Model
- New Diagnostic Techniques for Insulin Resistance
- KineMed
- Isotechnika
- Syn X
- LipoScience
- Entelos
- Outlook
- About the Authors
- Appendix A. Etiology and Pathophysiology of Insulin Resistance
- Etiology
- Pathophysiology
- Appendix B. Bibliography
- Tables
- 1. Studies Demonstrating the Relationship Between Insulin Resistance, Diabetes, and Cardiovascular Diseases
- 2. Updated NCEP-ATP III Criteria for Metabolic Syndrome from the AHA and NHLBI
- 3. Prevalence of Insulin Resistance in Various Populations
- 4. Number of Total Prevalent Cases of Insulin Resistance Segmented by Type 2 Diabetic and Nondiabetic Subpopulations in the United States and Major European Markets, 2006-2016
- 5. Indexes Currently Used to Assess Insulin Resistance
- 6. Select Novel Tests and Indexes for Insulin Resistance
- 7. Select Companies with Diagnostics for Insulin Sensitivity/Resistance
- 8. Clinical Trials for the Pharmacological Prevention of Type 2 Diabetes
- A-1. Risk Factors for Insulin Resistance
- Figures
- A-1. Clinical Progression of Insulin Resistance
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