Discoveries and Challenges in Early-Stage ApoptosisDecision ResourcesNovember 14, 2005 15 Pages - SKU: DECR1188228 |
| Apoptosis, the major and best-studied pathway of programmed cell death, plays an important role in embryonic development, the immune system, and protection against mutations and cancer. As such, it has become an intriguing focus of investigation among pharmaceutical companies seeking to treat illnesses ranging from cancer to cirrhosis. In this report, we explain the apoptotic process, discuss several proteins within the apoptotic pathways that may represent potential targets for drug development, describe apoptosis modulators and inhibitors in development, and analyze the challenges associated with developing agents that target this pathway, especially those associated with caspase inhibitors.
Please note: the PDF e-mail from publisher version of this report is for a global site license. |
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