Proteomics is a rapidly evolving field that is rife with commercial opportunities as the technology achieves ever higher throughput at lower cost and greater sensitivity. Proteomics: Current State and Future Directions is a new CHA Advances report that delivers an up-to-the-minute assessment of the state of proteomics and its applications in drug and biomarker discovery. The report provides insight into:
- Strengths and weaknesses of the leading technologies for protein separation, detection, and quantification - with an emphasis on high-throughput approaches
- The fundamental challenge posed by the vast dynamic range among protein concentrations, and the potential solutions in development and entering the market
- Recent applications of proteomics to discover biomarkers for preeclampsia, and for neonatal ureteropelvic junction, and to differentiate between diagnosis of ALS and Parkinson’s disease
- Technologies such as mass spectrometry, antibody-bearing chips, and solution array multiplexing to address the challenge of detecting low-abundance proteins
- The most significant research initiatives and recent product introductions, company profiles, and the major deals and M&As that are shaping the proteomics landscape
A quantitative survey (N=81) of individuals involved with proteomics at biopharmaceutical and diagnostic firms, vendors of equipment and services, and academic research departments sheds light on current practices and future directions in the use of proteomics in pharmaceutical R&D. Among the highlights:
- 69% of respondents are using proteomics to discover novel biomarkers
- Antibody/protein arrays and solution arrays will begin to gain ground as detection platforms over the next 3 years
Expert interviews with 3 authorities on proteomics provide penetrating commercial and scientific insights into the state of the art. Roger Brent, PhD (president and research director of the Molecular Sciences Institute in Berkeley, CA, and cofounder of Aptanomics SA) examines the commercial opportunity and economic realities of using proteomics in the clinic. Gilbert S. Omenn, MD, PhD (co-director of the Human Proteome Organization’s Plasma Proteome Project and professor/director of the Center for Computational Medicine and Biology at the University of Michigan) discusses solutions for overcoming the problem of high protein concentration in plasma samples. James R. Heath, PhD (professor of chemistry at California Institute of Technology) shares his vision of dynamic, multiparameter network models, driven by nanotechnology, that describe how biological systems change over time.
|
- SECTION 1 Introduction: The Current State of Proteomics Technology
- SECTION 2 A Brief History of Proteomics Technology
- SECTION 3 General Overview of Proteomics Research Challenges
- SECTION 4 Current Technologies
- Protein Separation/Sample Enrichment
- Liquid Chromatography
- Protein Removal
- Mass-coded Labeling
- SECTION 5 Research Comparing Quantification Methods
- Protein Identification and Quantification
- Mass Spectrometry
- Common MS Instrument Types
- Antibody/Protein Array Applications
- Protein Indentification and Quantification, Antibodies
- Protein-Protein Interaction
- SECTION 6 Technical Challenges
- Dynamic Range
- Albumin Removal
- SECTION 7 Selected Research Methods Reports
- Protein microarrays
- Sample Complexity
- Multiphoton Detection
- SECTION 8 Selected Product Introductions
- Beckman-Coulter
- Sigma-Aldrich
- Cambrex
- Serva Electrophoresis
- PerkinElmer
- Thermo Electron
- Sigma-Aldrich
- Agilent Technologies
- Bruker Daltonics
- KREATECH
- Axela Biosensors
- Syngene
- Sigma-Aldrich
- SECTION 9 Selected Deals and Mergers
- Combi Matrix\Biodesign Institute
- Caprion\ICOS
- Affibody\Agilent
- PerkinElmer\Agilix
- Applied Biosystems\Invitrogen
- PerkinElmer\Luminex
- SECTION 10 Expert Interviews: Current State and Future Directions
- Roger Brent, PhD
- Gilbert S. Omenn, MD, PhD
- James R. Heath, PhD
- SECTION 11 Selected Company Profiles
- BiaCore
- BioRad
- Invitrogen
- Luminex
- Thermo Electron
- APPENDIX
- CHA Advances - 2006 Proteomics Survey
- References
- List of Tables and Figures
- Figure 1. ClinProt Workflow
- Figure 2. Luminex 200 System
- Figure 3. Agilent's Multiple Affinity Removal System
- Figure 4. Bruker Daltonics' Microflex
- Figure 5. Invitrogen's ProtoArray
- Figure 6. Sigma-Aldrich's ProteoPrep 20
- Figure 7. Agilent's HPLC/MS Chip
Share this report
Other tasks Related Markets Drug Discovery Reports Free Alert Me service Receive bi-weekly email alerts on new market research Sign Up Today!
|
