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Epigenetics: Technologies, Applications, and the Commercial Landscape

CHI Insight Pharma Reports
February 1, 2008
130 Pages - SKU: CHI1692982

Abstract Table of Contents Related Reports

Epigenetics is one of the fastest-growing areas of the biological sciences. It’s also a budding industry. This new report offers in-depth analysis of:

The definition, history, and current status of epigenetics
Current and potential commercial applications
An epigenetic approach to cancer etiology
The epigenetics of noncancerous diseases
DNA methylation and histone modifications as biomarkers
The companies involved and their products
Epigenetic therapeutics: demethylating agents, histone modifications, and combinations
The drivers of the epigenetics industry, plus recent major industry deals and patent applications
Results of a quantitative online survey of individuals involved in epigenetics R&D

Epigenetics: Technologies, Applications, and the Commercial Landscape provides an overview of the scientific and technological landscape from which both the diagnostic and therapeutic sectors of the nascent “epigenetics industry” are emerging, plus a qualitative analysis of the scientific, technological, and commercial achievements and challenges facing both sectors.

The number of peer-reviewed research articles being published on epigenetics is increasing practically exponentially.

Biologists are recognizing that to understand human health and disease, they need to know more than the DNA sequence of any genes. Equally, if not more important, they need to know how cells use the information encoded in the genome. That information is essentially stagnant if a gene lies dormant. What turns genes on and off, and under what circumstances? That is what epigenetics is all about: how genomic information encoded in the DNA sequence is regulated by various nonDNA factors. The science and technology of epigenetics are aimed at understanding and, ultimately, manipulating the various chemical and physical chromatin modifications that control gene expression.

This report focuses on the 2 major types of epigenetic control factors:

DNA methylation patterns formed by the presence of methyl molecules (-CH3) attached to CpG dinucleotides along the entire length of the DNA double helix
Various covalent modifications to the histone proteins around which the DNA helix is wound

Epigenetics: Technologies, Applications, and the Commercial Landscape is a valuable tool for anyone involved in epigenetics R&D, portfolio management, and commercialization of diagnostics and therapeutics.

Chapter 1
EPIGENETICS TODAY: 1.1 What Epigenetics is All About; 1.2. DNA Methylation and Histone Modifications: Focus of This Report; 1.3. The Etiology of Cancer: From a Mutational to Epigenetic Understanding; 1.4. The Epigenetics of Noncancerous Diseases
Chapter 2
DNA METHYLATION BIOMARKERS AND TECHNOLOGY: THE RACE IS ON: 2.1. The Mechanisms of Epigenetics; 2.2. The Power of DNA Methylation: Biomarker or Bust; 2.3. Homebrew Methylation Testing; 2.4. Epigenetic Diagnostic Companies; 2.5. DNA Methylation Technology; 2.6. The Future is Genomewide; 2.7. DNA Methylation Research Prep Kits and Service Contracts: Making It Easy
Chapter 3
EPIGENETIC DRUGS: THE RACE TO REVERSE SILENCING: 3.1. The Dynamic Nature of the Epigenome; 3.2. Demethylating Agents; 3.3 Histone Modifications: Using Drugs to Restore Acetylation; 3.4. Combination Therapy: Epigenetic Drugs Make Good Partners
Chapter 4
The Business of Epigenetics: 4.1. What is Driving Industry Interest in Epigenetics?; 4.2. The "Epigenetics Industry"; 4.3. Industry Snapshot #1: Recent Major Business Deals; 4.4. Industry Snapshot #2: Recent Patent Applications Related to Epigenetics
Appendix: Insight Pharma Reports - Epigenetics Survey - January 2008
References
Company Index with Web Addresses
Tables: Table 1.1. Major Commercial Applications of Epigenetics; Table 1.2. Types of Epigenetic Control Factors and Their Potential Commercial Utility; Table 1-3 Total Sales for FDA-Approved Epigenetic Therapeutics Already on the Market; Table 1.4. Diseases With Epigenetic Etiologies: A Growing List; Table 2.1. Select List of Epigenetic Diagnostics in Development; Table 2.2. Ways to Analyze DNA Methylation; Table 2.3. Clinical Applications of DNA Methylation Biomarkers; Table 4.1. Future Market Growth: Diagnostics, Therapeutics, and Research Tools; Table 4.2. 10 Recent Major Business Transactions in the Emerging Epigenetic Sector of the Life Sciences Industry
Figures: Figure 4.1. The Rising Popularity of Epigenetics in the Scientific World; Figure 4.2. SWOT Analysis: Epigenetic Diagnostics; Figure 4.3. SWOT Analysis: Epigenetic Therapeutics; Figure 1A. Types of Organizations; Figure 2A. Titles of Respondents; Figure 3A. Responsibilities: Basic Science to Regulator; Figure 4A. Length of Time in Epigenetics; Figure 5A. Depth of Epigenetics Research; Figure 6A. Plans for Expansion; Figure 7A. Epigenetic Biomarker Discovery and Development; Figure 8A. Diagnostic and Therapeutic Categories; Figure 9A. Primary Focus of Research; Figure 10A. Primary Application of Epigenetic Profiling; Figure 11A. Growing Interest and Investment; Figure 12A. Gold Standard for DNA Methylation; Figure 13A. High-Throughput Technologies; Figure 14A. No Research Technology of Choice for Now; Figure 15A. No Clinical Technology of Choice; Figure 16A. Epigenetics Market Growth Projections; Figure 17A. Potential Commercial Availability of Epigenetic Products; Figure 18A. Advances in Diagnostic/Biomarker Development; Figure 19A. Advances in Therapeutics; Figure 20A. Gap or No Gap

Epigenetics: Technologies, Applications, and the Commercial Landscape

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