Autoimmune Diseases: Pipelines for Crohn's Disease, Multiple Sclerosis and Rheumatoid Arthritis
CHI Insight Pharma Reports
June 1, 2011 SKU: CHI6428956
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This report focuses on current and pipeline candidate therapeutics and their respective targets for three autoimmune diseases and answers such questions as:
- Who are the companies with active development programs for these diseases?
- Which targets are actively being investigated and what new targets are coming forward?
- Who has candidates in active Phase III and Phase II clinical trials?
- What does the overall target activity map, from launched drug to preclinical research candidates look like?
- Where are next generation biological therapeutics found across these three diseases?
- Are small molecules a significant portion of the development activity?
Autoimmune Diseases: Pipelines for Crohn’s Disease, Multiple Sclerosis and Rheumatoid Arthritis describes pipeline activities across these three diseases. We report on the:
- Development pipelines for each disease providing information on company and licensee involvement.
- Active Phase III and Phase II clinical trials and provide study completion dates.
- Targets involved across the spectrum of launched and preclinical activities.
- Competition among companies developing therapeutics targeting the same or related physiology.
- Pace of development activities across these three diseases.
- Small or specialty companies with innovative therapy development programs.
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- Chapter 1
- 1.1 Introduction
- 1.2 Autoimmune Diseases as an Indication Category
- Opportunity Map for Pharma R&D
- Global Pharmaceutical Sales for the Leading 15 Therapy Classes.(2009)
- Average Per-Patient US Clinical Trial Costs (2008)
- Alliance activity (2007-2009 for upfront cash values> $10 million)
- Chapter 2
- OVERVIEW OF THREE MAJOR AUTOIMMUNE DISEASES BEING TARGETED BY PHARMACEUTICAL AND BIOPHARMACEUTICAL COMPANIES
- 2.1 Autoimmune Disease Introduction
- IMMUNOSTIMULANTS
- IMMUNOSUPPRESSANTS
- 2.2 Crohn¡¦s Disease
- 2.3 Multiple Sclerosis
- 2.4 Rheumatoid Arthritis
- 2.5 Conclusion
- Chapter 3
- THERAPIES LAUNCHED AND IN DEVELOPMENT FOR TREATMENT OF CROHN¡¦S DISEASE
- 3.1 Introduction
- 3.2 Approved Therapeutics
- Biologics
- Targeting TNF- Ą
- Targeting Integrins
- Glucocorticoid Agonists
- Prostaglandin Inhibitors
- 3.3 Drug Candidates in Phase III Clinical Trials
- VLA-4 receptor candidates
- CCR9 chemokine receptor
- Others
- 3.4 Drug Candidates in Phase II Clinical Trials
- Cytokines: Interleukins
- Immunomodulator
- Receptors
- Stem Cell
- Other
- Cytokines: Interleukins
- Enzyme Inhibitor
- Receptors
- 3.5 Targets in Early Development for Crohn¡¦s Disease
- 3.6 Activity Map of Crohn¡¦s Disease Targets of Launched Drugs and Development Candidates
- Chapter 4
- MULTIPLE SCLEROSIS
- 4.1 Introduction
- 4.2 Launched Drugs for MS and Other Approved Indications
- Cytokine ¡V Interferon Receptors
- Interleukin Agonist
- Cyclic AMP Stimulant
- Targeting Integrins
- Ion Channel antagonist
- GPCR - Sphingosine 1-phospate receptor agonist
- 4.3 Companies with Multiple Sclerosis Candidates in Phase III Clinical Trials
- CD52 Antigen
- CD20 Antigen
- Interferon
- Enzyme Inhibitor
- 4.4 Companies with Multiple Sclerosis Candidates in Phase II Clinical Trials
- CD20 Receptor
- Anti-TNF Products
- 4.5 Companies with Multiple Sclerosis Candidates in Early Development
- 4.6 Activity Map of Multiple Sclerosis Targets of Launched Drugs and Development Candidates
- Chapter 5
- RHEUMATOID ARTHRITIS PIPELINE
- 5.1 Introduction
- Medications for Rheumatoid Arthritis
- 5.2 Launched Therapeutics for Rheumatoid Arthritis
- CD Binding
- Interleukin Receptor
- Anti-TNF Targeting
- 5.3 Phase III Compounds in Development
- Cytokines
- Interleukins
- TNF family
- CD20 Receptor
- Kinase Inhibitor
- 5.4 Phase II Compounds in Development for Rheumatoid Arthritis
- C5a Antagonist (GPCR Receptor)
- Chemokine Receptor Antagonist
- CD20 Antagonist
- Enzyme Inhibitors
- Dihydrofolate reductase inhibitor
- Dihydroorotate dehydrogenase inhibitor
- Janus Kinase Inhibitor
- Cytokines
- TNF-ƒÑƒn
- Cytokine Receptors
- Granulocyte macrophage colony stimulating factor antagonist
- Interleukins
- Natural killer cell inhibitor
- Stem Cell Therapy
- Anti-lymphotoxin alpha
- Others
- 5.5 Targets in Early Development for Rheumatoid Arthritis
- 5.6 Activity Map of Rheumatoid Arthritis Targets of Launched Drugs and Development Candidates
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