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Advances in the Use of Biomarkers in Biochip and Microarray Testing: Innovative technologies, growth opportunities and the future market outlook

Business Insights
October 1, 2009
251 Pages - SKU: RET2473323

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Microarrays and biochips are small devices capable of detecting and measuring large numbers of biomarkers simultaneously. Although microarrays have been in research use for over a decade it is only recently that they have moved towards meeting the requirements of the clinical and regulatory communities with the first DNA microarray test being approved by the US FDA in 2007. Further development of microarrays heralds the introduction of faster diagnosis times and will further enable personalized medicine. This report covers future developments in key segments of the microarray market including DNA, protein, tissue and cell microarrays and lab-on-a-chip technologies, providing market forecasts to 2013. In addition the report gives insights into the developmental programs of 45 leading players in this market.

Advances in the use of biomarkers in biochip and microarray testing
Executive Summary: Biochips, biomarkers, and in vitro diagnostics; DNA microarrays; Protein microarrays; Tissue and cell microarrays; Lab-on-a-Chip technologies; Biochip companies; Market Analysis and Forecasts
Chapter 1 Biochips, biomarkers, and in vitro diagnostics: Summary; Biomarker-based IVDs; Introduction to biochips; Microarrays; Microfluidic chips; Background on nucleic acid and protein testing; Immunoassay technology; Immunoassay formats; Rapid immunochromatographic assays; Multiplexed assays; Nucleic acid testing; Probe-based NAT; Amplification technologies; Biomarker discovery and validation; Translating biomarkers into IVDs; Regulation of in vitro diagnostics; Europe; USA; Draft guidance on multivariate analysis
Chapter 2 DNA microarrays: Summary; Introduction; DNA microarray fabrication technologies; Standard microarrays; 3-D DNA microarrays; Particle (bead)-based microarrays; Analytical uses of DNA microarrays; SNP genotyping; Detection of genetic imbalances; Gene expression profiling; Single-channel microarrays; Two-channel microarrays; Methods utilizing RT-PCR; MicroRNA expression profiling; Limitations and barriers to commercialization; Key commercial players; DNA microarray testing in cancer; Overview; Progress in breast cancer; Early detection; Classification, prognosis, and treatment; Tumors of unidentified origin; Other advances; DNA microarray testing in genetic disorders; Microarrays testing for adverse drug reactions; DNA microarray testing in transplant management; DNA microarray testing in other conditions; Expanding applications
Chapter 3 Protein microarrays: Summary; Introduction; Background on proteomics; Protein microarray technologies; Formats; Glass slides; Microwell/nanowell chips; Implementation; 3.3.2.1 Forward-phase microarrays; Prospects for multiplex ELISAs; Reverse-phase microarrays; Detection of bound targets; SELDI ProteinChip technology; Fabrication technologies; Dispensing technology; Protein immobilization strategies; Surface chemistries; Analytical uses of protein microarrays; Commercial microarrays for clinical research; Protein microarray diagnostics in cancer
Chapter 4 Tissue and cell microarrays: Summary; Introduction; Tissue microarrays; Advantages; Construction; Sources of tissue; Scanning and analysis; Companies providing products and services; Uses of tissue microarrays; Clinical investigations in cancer; Initiatives using cell microarrays; Overview; Examples of diagnostic applications
Chapter 5 Lab-on-a-Chip Technologies: Summary; Introduction to microfluidics; Lab-on-a-chip devices; Construction methods; Companies and technologies; Multiplexed particle assays; Multiplexing at the microlevel; Particle encoding technologies; Applications of LoC devices; Changing diagnostics; Future role in PoC testing
Chapter 6 Biochip companies: Introduction/Summary; Accelr8 Technology Corporation; Company description; Microarray-based rapid bacterial analysis; Advanced Liquid Logic Inc; Company description; Digital Microfluidics devices; Affymetrix Inc; Company description; DNA and protein microarrays; Agendia BV; Company description; Gene expression microarray diagnostics; MammaPrint; TargetPrint; CupPrint; ColoPrint; Agilent Technologies Inc; Company description; DNA microarrays; Almac Group Ltd; Company description; Microarray-based gene expression profiling; Ambry Genetics Corp; Company description; Microarray-based cytogenetic testing; Applied Microarrays Inc; Company description; 3-D DNA microarrays; Arrayit Corp; Company description; Universal DNA microarray-based diagnostics; ArrayXpress Inc; Company description; Microarray services; Atactic Technologies Inc; Company description; Specialty microarrays; Aushon BioSystems Inc; Company description; Protein microarrays and services; AutoGenomics Inc; Company description; 3-D DNA microarrays for diagnostics; Beecher Instruments Inc; Company description; Tisue microarray products and services; BioArray Solutions Ltd; Company description; Bead-based microfluidic arrays; BioDot Inc; Company description; Protein biochip manufacture; Caliper Life Sciences Inc; Company description; Microfluidic lab-on-a-chip systems; CapitalBio Corp; Company description; Microarray systems and diagnostics; CombiMatrix Corp; Company description; DNA microarray technology and diagnostics; Cybrdi Inc; Company description; Tissue microarray products and services; Decision Biomarkers Inc; Company description; Microarrays for multiplex immunoassays; Epigenomics AG; Company description; Methylation microarrays for diagnostics; ExonHit Therapeutics SA; Company description; Differential gene expression profiling; Expression Analysis Inc; Company description; DNA microarray-based testing services; GeneNews Ltd; Company description; Gene expression diagnostics; GenTel BioSciences Inc; Company description; Protein microarrays and research kits; Illumina Inc; Company description; Bead-based microarrays; Imgenex Corp; Company description; Tissue microarrays; Iris BioTechnologies Inc; Company description; DNA microarrays for diagnostic profiling; LC Sciences LLC; Company description; Microarray products and services; Life Technologies Corp; Company description; Microarray/microfluidic research tools; Luminex Corp; Company description; Bead suspension microarrays and diagnostics; Maxwell Sensors Inc; Company description; Microarray and microfluidic products; Med BioGene Inc; Company description; Gene expression microarrays for diagnosis; Micronics Inc; Company description; Disposable microfluidic diagnostic labcards; Micronit Microfluidics BV; Company description; Microfluidic glass chips; Oxford Gene Technology Ltd; Company description; DNA and protein microarrays; Protein BioTechnologies Inc; Company description; Protein and tissue microarrays; Response Genetics Inc; Company description; Microarray gene expression cancer testing; Roche NimbleGen Inc; Company description; DNA microarray products and services; SABiosciences Corp; Company description; DNA microarrays and RT-PCR arrays; Signature Genomic Laboratories LLC; Company description; Microarray-based cytogenetic diagnostics; SomaLogic Inc; Company description; Aptamer microarrays; US Biomax Inc; Company description; Tissue microarrays; Xceed Molecular Corp; Company description; 3-D DNA microarrays
Chapter 7 Market analysis and forecasts: Summary; Introduction; DNA microarray review; Market history; Some leading players; Market growth; Protein microarray review; Market history; Some leading players; Market growth; Market segmentation and forecasts; Market prospects
Chapter 8 Appendix 1 Abbreviations and: Acronyms; Scientific/technical/medical terms; A2.2 Institutional/regulatory terms
Chapter 9 Appendix 2 Research: Methodology; Index
List of Figures: Figure 1.1: Non-competitive “sandwich” assay; Figure 2.2: An approx 18,000-test gene microarray; Figure 3.3: Principle of a spatially addressable protein microarray
List of Tables: Table 2.1: Companies featured in Chapter 2; Table 2.2: DNA microarray technologies/products; Table 2.3: Systems for gene expression profiling; Table 2.4: Gene expression tests in breast cancer; Table 2.5: Other cancer tests; Table 2.6: DNA microarray testing in genetic disorders; Table 3.7: Companies featured in Chapter 3; Table 3.8: Protein microarray technologies/products; Table 3.9: Protein microarrays for clinical research; Table 3.10: Protein microarray-enabled cancer diagnostic discovery; Table 4.11: Companies and products featured in Chapter 4; Table 5.12: Companies and products featured in Chapter 5; Table 7.13: Microarray Industry Bibliometric Output, 2000-2008; Table 7.14: Snapshot of FDA approved in vitro diagnostic microarray products; Table 7.15: Microarray Forecasts ($m); Table 7.16: Leading Company Market Shares

Advances in the Use of Biomarkers in Biochip and Microarray Testing: Innovative technologies, growth opportunities and the future market outlook

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