RNA (miRNA, RNAi & siRNA) Therapy in Oncology Drug Pipeline Update 2013Potentially any disease-causing gene, cell type or tissue can be targeted with miRNA, RNAi or siRNA, including those not ’druggable’ with small molecules or protein-based therapies.
There are today 51 companies plus partners developing 73 RNA (miRNA, RNAi & siRNA) drugs in 100 developmental projects in cancer. In addition, the accumulated number of ceased drugs over the last years amount to another 25 drugs. Rna (Mirna, Rnai & Sirna) Therapy In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 54 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 30 out of the 40 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 25 classifications of molecular function and with pathway referrals to BioCarta, KEGG. NCI-Nature and NetPath.
How May Drug Pipeline Update Be of Use?
- Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
- Find competitors, collaborations partners, M&A candidates etc.
- Jump start competitive drug intelligence operations
- Excellent starting point for world wide benchmarking
- Compare portfolio and therapy focus with your peers
- Speed up pro-active in-/out licensing strategy work
- Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.
Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.
Drug Pipeline Update at a Glance
Investigators
Includes more than 51 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
Note: You are able to sort and find drugs according to companiess and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.
Drug name & Synonyms
Lists commercial, generic and code names for drugs.
Developmental stage
This Drug Pipeline Update contains 73 RNA (miRNA, RNAi & siRNA) drugs in development, which have a total of 100 developmental projects in cancer. In addition there are ceased drugs.
Pipeline Breakdown According to Number of Drugs
Phase II# 3
Phase I# 9
Preclinical# 69
Suspended# 0
Ceased# 25
Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.
Indications
Included RNA (miRNA, RNAi & siRNA) drugs are also in development for 31 other indications, where of 25 are different cancer indications.
Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.
Targets
Mutations
All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 30 out of the 40 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
Biological Structures
The identity of available biological structures on 33 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 578 structures available today among drug targets.
Identified drugs are linked to more than 54 different targets, divided into 25 classifications of molecular function:
- Cell adhesion molecule activity
- Cofactor binding
- Cytokine activity
- Growth factor activity
- GTPase activity
- Kinase activity
- Ligand-dependent nuclear receptor activity
- Metallopeptidase activity
- Molecular function unknown
- Motor activity
- Oxidoreductase activity
- Peroxidase activity
- Protease inhibitor activity
- Protein serine/threonine kinase activity
- Protein threonine/tyrosine kinase activity
- Receptor activity
- Receptor binding
- Receptor signaling complex scaffold activity
- RNA binding
- Structural molecule activity
- T cell receptor activity
- Transcription factor activity
- Translation regulator activity
- Transmembrane receptor protein tyrosine kinase activity
- Unknown
Sub-Cellular Localization
Identified targets are categorized into 15 different primary and alternate sub-cellular localizations:
- Cell junction
- Cell surface
- Centrosome
- Clathrin-coated vesicle
- Cytoplasm
- Cytoskeleton
- Endoplasmic reticulum
- Endosome
- Extracellular
- Golgi apparatus
- Microtubule
- Mitochondrion
- Nucleolus
- Nucleus
- Plasma membrane
Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.
Target Expression Profile
Direct links are provided from inside the application to 44 protein expression profiles of 31 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
48 different normal tissue types 20 different types of cancer 47 cell lines 12 samples of primary blood cellsPathway Referals
Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
BioCarta# 122 Pathways KEGG# 98 Pathways NCI-Nature# 146 Pathways NetPath# 19 PathwaysNote: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.
Mechanism
In total there are different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.
Compound
Identified drug compounds are described by:
Compound type, Chemical name, CAS Number and molecular weight
Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.
Drug Profile
Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms
Principal Company & Partners
Presentation of principal company and partners
Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol – Chromosome Location – Gene & Protein Name – Molecular Function
Target Localization
Described target(s) is/are presented with primary and alternate localizations.
Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells
Mutation
All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
Biological Structures
The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.
Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.
Mechanism
Drug mechanism of action
Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.
Example:
Cancer, myeloma – Phase II Clinical Trial – Active
Cancer, prostate – Phase III Clinical Trial – Ceased
Drug Description
Short introduction to drug
Compound Data
Compound type, Chemical name, CAS Number and molecular weight
Patent Data
Available patent information related to the drug is presented here.
Fillings and Approvals
Approvals and submissions
Analyst comments
Deals & Licensing
Collaborations and deals
Availability for licensing
Phase IV Data
Available Phase IV development data, developmental history and scientific data.
Phase III Data
Available Phase III development data, developmental history and scientific data.
Phase II Data
Available Phase II development data, developmental history and scientific data.
Phase I Data
Available Phase I development data, developmental history and scientific data.
Phase 0 Data
Available Phase 0 development data, developmental history and scientific data.
Preclinical Data
Available preclinical development data, developmental history and scientific data.
Discovery Data
Available discovery development data, developmental history and scientific data.
Application Features
Search, Find and Filter Panel with Initial Result Presentation
With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.
Direct linkage from inside the application to related internet resources
- Drug data is linked to search engines like Google and PubMed
- Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
- Direct links to company web pages of companies
Dynamic Report Generator
Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.
System Requirements
- Operating system: Windows (2000/XP/Vista/7) and Mac OS X 10.6 (Snow Leopard) and OS X 10.7 (Lion)
- Browser Application (Internet Explorer)
- Internet access (to access related internet resources)
