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Biopharmaceutical Expression Systems and Genetic Engineering Technology

BioPlan Associates, Inc.
November 1, 2008
415 Pages - SKU: DFAQ2174877

Abstract Table of Contents Related Reports

Comprehensive Review of Expression
Systems for Biopharmaceutical
Manufacturing

New biopharmaceutical expression systems are beginning to revolutionize the industry! Lower costs and efficiencies of newer expression systems are driving these changes. Our new study provides you all the information you need to begin the shift to increased productivity. Since the 1970s little has changed in the technologies used for commercial-scale biomanufacturing (E. coli, CHO cells, or S. cerevisiae as hosts). But that’s all beginning to change. This report tells you where, by whom, and how!

Coverage includes host cells/organisms, basic genetic engineering methods, recombinant constructs , organisms, vectors, promoters, selection and amplification methods, chaperones, and technologies that improve expression of glycoproteins and antibodies.

315 Data-packed pages
439 Monographs
286 Companies profiled
40 Multi-platform technologies
71 Bacteria and prokaryotes
42 Yeasts
28 Mammalian
Dozens of plants, insects, cell-free, human, chicken, hybridomas & more
Scores of vectors, promoters, selection & amplification methods, chaperones for commercial-scale biomanufacture
What You’ll Get

The single most informative source for commercial biomanufacturing expression systems and technologies.
Conduct further research: Contact technology licensing sources.
Find what fits: Large and small drug innovators, CMOs, biogenerics companies developing new licensing/income streams; innovators dreaming of starting a new company, will find opportunities.
Find good investments: Ample opportunities to get involved at the early stages of technology licensing.
Find technological advances: Ready for adoption, adaptation and development, opportunities for process improvements and profit.

Cell-free systems: Cell-free expression, ATP regeneration system; Cell-Free Protein Synthesis (Cell-Free); Large ribosomal subunit proteins, E. coli - cell-free systems
Broad, cross- or multi-platform technologies: In vivo linearization; InVoLin; Meganuclease Recombination System (MRS) - improved transformation; Vectors, site-specific recombinase assembly - eukaryotes; Glycosylation, mammalian [Generic entry]; Aminoglycoside phosphotransferase marker; Neomycin phosphotransferase I (nptI) marker;; Geneticin (G-418) selection - universal; Cellulose binding domain (CBD) fusion protein affinity tags; pET-CBD - universal; Controllable Self-Cleaving Intein Derivative; IMPACT-CN; pH-sensitive self-cleaving fusion; protein affinity purification tag - universal; Cotransformation, Columbia University - eukaryotes, selection; Cre-lox mediated in vitro recombination; Cyclization Recombination/locus of X-over P1;; site-specific recombination (SSR) - universal; genetic recombination; deltaPhase; Elastin-like polypeptide (ELP) fusion protein tags - chromatography-free; purification; universal; Directed Nuclease Editor (DNE); Meganuclease Design - universal; Dual expression vectors; Dual Affinity ReTargeting (DART) - antibodies; bacteria and mammalian cells; Expression enhancers, oligonucleotides - universal; Expression factory; baculoworkstation - automated parallel expression; Fusion protein expression systems; Affinity purification tags and chaperones - universal; Fusion proteins, self-cleaving, pH-sensitive - universal; Glutathione-S-transferase (GST) fusion protein affinity tags; pGEX vectors; GUS reporter system (beta-glucuronidase); GUS control vector - prokaryotes; plant cells;mammalian cells, non-vertebrate; Heat shock Promoters (HSPs); HSP chaperones; His tags; Poly-Histidine fusion affinity tag technology; 6xHistidine-tag - univeral;purification tags; His-tags; Poly-Histidine fusion affinity tag technology - univeral; purification tags; Hybridomas (Kšhler and Milstein) - monoclonal antibodies; Biopharmaceutical Expression Systems and Genetic Engineering Technologies; Lambda recombination protein; Homologous recombination; Meganuclease Recombination System (MRS)/I-SceI; homologous recombination -; universal genetic recombination; Mucin promoters; IIM14 and IIM22 - vector enhancers; New Cabilly; Cabilly-Boss; Monoclonal antibody 2-chains expression - universal; phCMV vectors; GenePORTER - universal; Poly(A) polymerase; Promoters; Recombinant DNA; Protein Expression; Cohen-Boyer; Reconstituting chemically orthogonal directed engineering (ReCODE) -; Unnatural amino acids; UAAs; E. coli; yeasts; mammalian cells; Selectable markers; Selection of transformed cells; Reporter genes; Small Ubiquitin-like Modifier (SUMO) fusion protein tags; Split SUMOpro System;; Ubl-specific protease - universal; Strep-tag affinity fusion protein tag; Strep-Tactin purification - universal; Super core promoters; SCP1; Core promoters - “the strongest [promoters] ever made”; TAGZyme; dipeptidyl aminopeptidase I (DPPI; DAPase Enzyme; cathepsin C) -; cleavage of His tags; universal; TEV Protease; Tobacco Etch Virus (TEV) NIa protease - cleavage of fusion; protein tags; universal; Transfection - universal; Translation Engineering expression; CODA; Computationally Optimized DNA; Assembly; Hot Rod Genes; Controlled Ribosomal Pausing - universal; White collar complex (WCC) promoter; UV light induction - universal; Minos transposon cell transformation - insect larvae; also eukaryotes; Coconut Express cell-free translation - plants
Prokayotes: Bacterial cell expression technology (BCE); araB promoter - antibody fragments;E. coli; prokaryotes; Subtilisin (psub) fusion protein tag expression; Profinity eXact expression - E. coli;bacteria; yeasts; CHO cells; Tetracycline-induced expression repression - prokaryotes
Bacteria: Bacillus megaterium expression - E. coli alternative; Bacillus subtilis, super-oxidizing strains; Thiol-disulfide oxidoreductases (TDORs);; Thioredoxin A (TrxA) depletion - disulfide bridge optimization; Bacterial artificial chromosome (BAC) expression; pBAC vectors - bacteria; Caulobacter crescentus expression; PurePro Caulobacter Expression System -; Caulobacter bacteria hosts; Clostridium Expression System; NTNH promoter from Clostridium botulinum; Flavobacterium heparinum expression - glycoproteins; Lactococcus lactis htrA- expression - protease depletion; Lactose (lac) promoters; Isopropyl-beta-galactosidase (IPTG) induction - bacteria; NIsin-Controlled gene Expression (NICE); Lactococcus lactis expression;nisA promoter - antibiotic selection; P170 Expression System;Lactococcus lactis expression; Pfenex Expression; Pseudomonas fluorescens biovar I (MB101) - E. coli alternative; Plasmids stabilization; Pseudoalteromonas haloplanktis TAC125 (PhTAC125) - cold expression; Quasi-synthetic vectors; Synthetic gene sequences in vectors - bacteria; Ralstonia eutropha expression; Alcaligenes eutrophus expression; Rhodospirillum rubrum (bacterial) expression - membrane proteins; Staphylococcus carnosus expresion; Subtilin Regulated Gene Expression; SURE competency - B. subtilis; E. coli expression/vectors; CASCADE expression; pALEX1 plasmids - E. coli; Choline-binding fusion affinity tags - bacteria; Clean Genome E. coli; Stripped-down E. coli; GroEL,GroES chaperones; Chaperonins - proper folding; universal; E. coli; Methylobacterium extorquens (bacterium) expression; CANGENUS; Streptomyces (lividans and griseus) expression; Saccharomyces cerevisiae expression; Streptomyces stationary phase expression; SPE system; Streptomyces vectors;; Secreted Protease Production (SPP) System; Streptomycetes hyper-inducible expression; PnitA-NitR system; Caprolactam; induction - Streptomycetes
Yeasts: ApoLife Yeast Expression; S. cerevisiae Twin Cassette Plasmids - antibodies in yeast; Arxula adeninivorans expression - alternative yeast; Chrysosporium lucknowense expression; C1 Express Hyperproducing Protein; Expression System - fungi; CoMed system; Universal Yeast vectors; pCoMed vectors; Arxula; adeninivorans-derived TEF1 promoter; Fungal expression systems; GlycoFi technology; Next Generation Biotherapeutics - Pichia pastoris; yeasts;; glycosylation; antibodies; Hansenula expression (yeast); Hansenula polymorpha (yeast) expression - E. coli alternative; Kluyveromyces lactis expression; pKLAC1; Acetamidase/Acetamide selection;; K. lactis GG799 - yeast; Entry Number Monograph Titles; Biopharmaceutical Expression Systems and Genetic Engineering Technologies; xiv; NeuBIOS expression; Neurospora crassa expression; NeuKARYON - filamentous fungi;glycosylation; Cabilly-Boss workaround; Neurospora expression; cotA promoter - fungi; Ophiostoma expression - ascomycetes fungi; Yeast expression systems; Zygosaccharomyces bailii expression; Zbleu2 strain - yeast; EASYEAST; Saccharomyces cerevisiae strains - easy protein release; Yeast cell lines and vectors; Saccharomyces cerevisiae cell lines - proper folding and glycosylation; Pichia pastoris expression; VelociMab; EESYR expression system; FASTR cell lines - CHO expression optimization;antibodies
Plants: Plastid Transformation; Translation-based vectors (TBV) - plants; Chlamydomonas reinhardtii chloroplast expression; promoter - algae, single-cell; Chlamydomonas reinhardtii expression - algae, single-cell; Drosophila Expression System (DES) - insect cell culture; Streptomyces lividans
Eukaryotes: Antibiotic inducible promoters - eukaryotes; AttSite recombinases - precise gene insertion; eukaryotes; Bovine growth hormone (bGH) polyadenylation sequence - eukaryotes; expression enhancement; Expression enhancers; Copy number increase - eukaryotic cells; Homologous Recombination; Knock-out/knock-in animals and cells; Internal Ribosome Entry Sequences (IRES) RNA translation enhancers; pCITE vectors;; Cardiovirus 2A IRES; pIRES - eukaryotes; Light-switchable promoters; Tetracycline (Tc; Tet) Expression Systems - eukaryotes; Zinc finger DNA-binding proteins (ZFPs); ZFP Transcription Factors - gene modification; mammalian cells; plant cells
Protozoa: Ciliate Performance Expression System; CIPEX system;; Tetrahymena (protozoa) expression; LEXSY; Leishmania tarentolae expression system - protozoa; Perkinsus marinus expression - protozoa express large proteins; TetraExpress; Tetrahymena (protozoan) expression; Tetrahymena thermophila (protozoan) expression
Animals, misc.: Milk protein promoter - proteins in milk of transgenic animals; Shrimp expression; Penaeus stylirostris expression; Taura Syndrome Virus (TSV); IRES vectors - glycoproteins; antibodies; Transgenic rabbits - humanized polyclonal antibodies
Mammalian: AmProtein vectors - “stongest mammalian vector set”; universal; Anti-apoptosis expression system; BCL-xL or BCL-2 expressing cell lines -; CHO, NS0, BHK, SP2/0-Ag14; Autocatalytic cleavage sites; Mengo virus vectors; Scission cassettes - mammalian cells; Cell adhesion optimization; cdkl3, siat7e, and lama4 genes - antibody-expressing cells; CMV (human) promoter; Cytomegalovirus promoter; Complete Control Inducible; Mammalian Expression System - mammalian cells; Cumate gene-switch; Q-mate Inducible Expression - mammalian cells; Dihydrofolate reductase (DHFR) System - selectable marker/amplification;; CHO and NS0 cells; Flp-In expression system; FLP-Mediated Gene Modification in Mammalian Cells; FLP; recombinase - mammalian cells; Gene-Activated (GA) expression, in vivo - mammalian cells; Glutamine synthetase (GS) System - NS0, CHO, mammalian cells; GPEx Gene Product Expression Technology - mammalian; CHO; MARtech; Matrix Attachment Regions; Scaffold Attachment Regions;; SARs - mammalian cells; RheoSwitch Mammalian Inducible Expression System; RheoSwitch Ligand RSL1; promoter; Ecdysone receptor induction - mammalian cells; adjustable expression; Selexis Genetic Elements (SGEs) - mammalian cell lines; STabilizing Anti-Repression; STAR elements - expression enhancement; mamalian cells; Ubiquitous chromatin opening element (UCOE) expression - mammalian cells; Whey acidic protein (WAP) milk promoters - mammals
Chinese hamster ovary (CHO) cells: ACE Expression System - MAb-expressing CHO cells lines; Boehringer Ingelheim High Expression System (BI HEX); CHO-DG44; CHO cell line (Puck); CHO-K1 cell line; CHO DG44 cells, DHFR-; CHO-DG44; DUK-XB11; CHO K1 DUX B11 (DHFR-) cells;; Dihydrofolate reductase selection/amplification, CHO cells; CHO SSF cell lines - adherent CHO cells; protein-free media; CHO Supercell; Targeted transfection; CHO DG44 cell line; CHOZn CHO DG44 cell lines - antibodies; GS-CHO Protein Free System; CHOK1SV cell lines - protein-free media; Sympress expression; Human polyclonal antibodies (rpAB) - CHO cells; Baby hamster kidney (BHK) 21 cells; ATCC CCL 10
Hybridomas: Human MORPHODOMA; Morphogenics; Hypermutation; PMS2 gene screening,; modification - human monoclonal antibodies from hybridomas; Cell-free system - glycoproteins; hybridoma; Ex-Cell EBx expression; EBx cells; Chicken embryonic stem cells;; Chicken EBx cells; Duck EBx cells
Chickens/Poultry: Chicken egg expression; Transgenic animals; Chicken rimordial germ cells (PGCs) - Human proteins/monoclonal antibodies in chicken eggs; OVA System; Avian Transgenic Biomanufacturing - chicken eggs expresssion; Transgenic poultry; avian transgenesis and nuclear transfer - proteins in chicken eggs; Windowing Technology - transgenics avians/chickens
Human: CEVEC Amniocyte Production (CAP) expression; Human amniocytes, immortalized; bcl-2 (p21) overexpressing NS0 cell lines - NS06A1(100)3 cell line - antagonize; apoptosis; Mabs; Cell fusion, NS0 cells - antibodies; Cholesterol/3-ketosteroid reductase (p3-KSR) expression - cholesterol; selection/induction of NS0 cells; GlycoExpress human cell lines; NM-F9 cell line - glycolysis; Human primary preB lymphocytes; HupreB cells - human monoclonal antibodies; NS0 murine myeloma cell line; NS0-PFCF cells; NS0 cells, protein- and cholesterol-free - antibodies; PER.C6 expression; Extreme density (XD) Technology - glycoproteins; antibodies; Retrotransposon vectors - transgenic avian/chicken cell culture; Sp2/0-Ag14 cells - protein-free media; antibodies; HEK 293 cell line, protein- and peptide-free (Hektor G) media; human; embryonic kidney (HEK 293) cell line -; HEK 293 expression; HEK 293 expression; HEK293 cell lines; HEK293SFE cell line; HKB-11 (HKB11) expression; Hybrid of kidney and B cells - HEK-293 alternative
Plants: Agrobacterium tumefaciens; Ti plasmids - transgenic plants; Antibiotic resistance markers - plants; Chloroplast expression - plants; Chloroplast Transformation Technology (CTT) - plant cells; Coupled regeneration/ transformation, plants; GENEWARE expression; Tobacco mosaic virus (TMV) vectors - tobacco; plants; Glyco-Engineered Moss; Physcomitrella patens expression; moss expression; promoting regions (MEPRs) - glycosylation; antibodies; iBioLaunch expression; Launch vectors - proteins and Mabs in plants; LEX System; Lemna (duckweed) expression - algae, whole plants; Nuclear transfer Cultured inner cell mass cells (CICM) - transgenic animals;; cloning from somatic cells; Nuclear Transformation Suite, plants; Plant expression - glycosylation; pPIPRA vectors - plants; public domain; ProCellEx Plant Expression - plant cells; glycosylation; Proficia expression - transient expression, plants; RNA-dependent RNA polymerase (RdRP) - universal; Stratosome Biologics System; Oilbody expression; Safflower plant seed expression; Super-mas Plant Gene Promoter; Gelvin promoter; (Aocs)3AmasPmas - plants; TransBacter Gene Transfer System -plants; royalty-free; Ubiquitin linkage domain - multiple proteins in transgenic plants; Ubiquitin plant promoters; Zara technology; Protein body-inducing sequence (PBIS) fusion proteins;; Recombinant protein body-like assembly (RPBLA); StorPro organelles; (protein encapsulation); Prolamin fusion proteins - eukaryotes; CleanGene plant transformation; Plastids (chloroplasts) expression - plant cell culture
Insects: High Five cell line (BTI-TN-5B1-4, ATCC CRL 10859); Trichopulsia ni cell line -baculovirus host cells; insect cell culture; Insect cells glycosylation; Insect cells glycosylation; Insect cells/Baculovirus expression systems; Baculovirus expression; vector systems (BEVS); PERLXpress; TRANSPILLAR larvae; Trichoplusia ni larvae expression -; transformed caterpillars; Trichoplusia ni (cabbage looper) cell lines; BTI-TN-MG1; ATCC CRL 10860;; BTI-TN-5B1-4; ATCC CRL 10859; Trichoplusia ni (cabbage looper) cell lines; H5CL-B and H5CL-F;; BTI-TN-5B1-4-derived insect cell lines; Baculovirus expression vector systems (BEVS); Entry Number Monograph Titles; InsectSelect Protein Expression System - insect cells; avoid baculoviruses; Mimic Sf9 Insect Cells - mammalian-like glycosylation; Polydnavirus vectors - insect cells; baculovirus altnerative; Pre-occluded Virus (POV) baculovirus vectors; Insect cells, per os (oral); baculovirus infection; Spodoptera frugiperda Sf-21 cell line - baculovirus host insect cells; Spodoptera frugiperda Sf-9 cell line - baculovirus host insect cells; NusA E. coli fusion proteins - eukaryotes; protein solubilization
Other broad/universal and older technologies: Enterokinase - fusion protein cleavage; Phage lambda promoters; PL promoter; PR promoter - E. coli; Phage T5 promoter; WI-38 cell line, Normal human fetal lung fibroblasts; Alkaline Phosphatase; Calf Intestinal Alkaline Phosphatase (CIAP) - prevent vector recircularization; Benzonase; Serratia marcescens endonuclease - polynucleotides breakdown; DNA Ligase (E. coli); Site-directed mutagenesis; T4 DNA Ligase; T4 RNA Ligase; More Specific and Component Technologies; Altogen transfection; RNAi gene silencing
Bacteria/Prokaryotes: Profuse vectors; Cisperone chaperone fusion tags - E. coli; Saccharomyces cerevisiae; Bacterial transcription promoters; BresaGen fusion protein expression - E. coli; Cold-Induced expression - Bacillus subtilis; desA promoter, iron-regulated; DmdR repressors - Actinomycetes; E. coli. vectors; Mnt-Arc promoters; T1 and T2 rrnB ribosomal terminators - bacteria; pAVEway expression - E. coli and Pseudomonas; pTAT-HA plasmids - E. coli; bacteria; Twin-arginine translocation (Tat) system; Tat nanomachine - protein folding, then secretion;bacteria; VegI promoters - Bacillus subtilis and E. coli; Xer-cise gene excision; Xer recombinases - Bacillus subtilis; Agrobacterium tumefaciens RpoA co-expression transcriptional activator - E. coli; Avidin affinity fusion protein affinity tags; Biotin purification; PinPoint Xa; Protein Purification System - E. coli; Biogenerics manufacturing technology packages - E. coli; BL21(DE3) competent E. coli cells; C-LYTAG affinity fusion protein tag; Streptococcus pneumoniae; N-acetylmuramoyl-L-alanine amidase LytA - E. coli; purification; Campylobacter jejuni glycosylation genes; OTase of C. jejuni - glycosylation; E. coli; Chaperone expression plasmids; DnaK, DnaJ and GrpE chaperones - E. coli; cis-Acting Peptide chaperones - E. coli; Codon-Optimized, Expression-Ready E. coli Clones; Continuous culture - bacteria; E. coli; Disulfide isomerase coexpression; DsbC and DsbG - E. coli; disulfide bonds and folding; Elastin-like polypeptide (ELP) self-cleaving fusion protein tags - chromatography-free purification; E. coli; ExpressProtect; p26, SicA, and alpha-crystallin-type fusion protein tags - E. coli; High copy number plasmids; pBGP120 - E. coli; High transformation efficiency (Hte) competency - E. coli cells; His-Patch ThioFusion System; pThioHis vector - E. coli; fusion proteins; N(pro) fusion protein tag, self-cleaving; Swine fever virus N(pro) autoproteolysis;; EDDIE - E. coli; OverExpress C41(DE3) and C43(DE3) - E. coli strains; OxlT plasmids; Oxalate/Formate Exchange Protein - E. coli; pBR322 - E. coli plasmid; antibiotic selection; pCold vectors; Cold Shock Protein A (cspA) promoters - E. coli, cold induction; pET Expression System; T7 promoter; pET Directional TOPO Cloning; Champion pET; Expression Vectors; T7 RNA polymerase (T7 RNAP) - E. coli; pMAL Protein Fusion and Purification System; Maltose binding (MBP) fusion; affinity tags; pMAL plasmids - antibody fragments; E. coli; Polyhydroxybutyrate (PHB) fusion tags, self-cleaving coexpressed with; affinity medium - E. coli; universal; Red/ET recombination; ET cloning/ET recombination; GET recombination;; Recombineering; £f Red-mediated recombination; lambda-mediated; recombination - E. coli; Skp and DsbC chaperone fusions - E. coli; secretion control; Tac promoters - E. coli; Tryptophan (trp) promoters - E. coli; WACKER Secretion System; E. coli K12-based secretion system - antibody fragments; Flavivirus vectors; Kunjin replicon vectors - prokaryotes; Streptomyces; prokaryotes; Streptomyces inducers; Streptomyces lividans strains; xysA promoters
Yeasts: AlcoFree Yeasts; Saccharomyces cerevisiae KOY.TM6* strains; ALEU2 marker; AHSB4 promoter; Arxula adeninivorans expression; Aspergillus niger expression; A. niger A4 promoters - humanized antibodies; Aureobasidin A vectors (pAUR) - selectable marker in yeasts; Calnexin chaperone - Hansenula polymorpha; yeasts; Chitin synthase (CHS1), Yeast growth factor, chitin synthase (CHS1) -; yeast promoter discovery; Estradiol-dependent enhancer; Gal4-ER-VP16 - yeasts; Formaldehyde dehydrogenase (FLD1) promoter; Formaldehyde selection -; Pichia pastoris; yeasts; GAPFL promoter; Glyceraldehyde-3-phosphate dehydrogenase-derived; promoter - yeasts; Gene Design, algorithmic - yeasts; Hypermutable yeast; PH05 promoter; Phosphate induction -yeasts; Vesicular fusion factor 2 protein (Vff2p) enhancer - yeast; bacteria; CHO cells; Vesicular fusion factor 2 protein (Vff2p) enhancer - yeasts; Xplor Vector System, yeast optimization; Antibody fragment expression - Saccharomyces cerevisiae; Saccharomyces cerevisiae, cold induction; Secretion Enhancer Vector System (SEVS); SecHancer vector - Saccharomyces cerevisiae; Mab Xpress Antibody Production System; Pichia pastoris - glycosylated antibodies; Pichia expression, rhamnose induction; Pichia GlycoSwitch System; Glycoswitch plamids - yeasts; glycosylation; Pichia pastoris antibody expression; Pichia pastoris AOX1 promoters; Pichia pastoris “super yeast”; Pichia pastoris AOX1 promoters; Aminoglycoside adenylyltransferase (aadA1) promoter - bacteria; eukaryotes; ColE1 plasmids, E. coli - prolonged viability
Mammals: CMV/R Promoter - eukaryotes; piggyBac transposon - eukaryotes; insect cells; Tax-inducible expression; Bovine leukemia virus (BLV) promoter - mammalian cells; BacMam; pBacMam vectors - mammalian vectors, baculovirus-based; Calnexin, calreticulin, Erp57, Hsp40, and Hsp70 chaperones - mammalian cells; CCT promoters - mammalian cells; ClonePixFL Selection - antibodies, mammalian cells; Hsp60, Hsp70, Hsp90, Hsp100 chaperones - mammalian cells; IRF-1 estrogen receptor promoter; Estradiol induction - mammalian cells; Osteoclast-associated receptor (OSCAR) promoter - mammalian; CHO cells; pAccAB vectors - antibodies; mammalian cells; RP Shift; Senescence induction; PACE Expression Vector - mammalian; cells; expression enhancement; antibodies; Semliki forest virus (SFV) vectors - mammalian and insect cells
Chinese Hamster Ovary (CHO) cells: CHEFl expression; CHO elongation factor-la (EF-Ialpha) promoter - CHO cells; CHO cells - antibodies; serum-free media; CHO cells dhfr RNA interference; RNA silencing vectors - CHO cells; CSL4S-342 CHO cells (CHO-K1 CSL4S-342); Osteoclast-associated receptor (OSCAR) promoter - mammalian; CHO cells; Pangen CHO expression; StableFast Biomanufacturing System; pBFdfhr.2 Expression Vector -; CHO cells; antibodies; Tandem Chimeric Antibody Expression (TCAE) vectors; ANEX vectors;; CHO cell line TCAE 8 (ATCC 9119); Kozak sequences, impaired - antibodies; UTR Clone Generation; UTRtech; “Cell Factories”; Gaussia luciferase signal; peptides - Mabs supersecretion; CHO cells; DNA microinjection - transgenic animals, chickens; HEK-293 cells; 293ST-3F6 cell line; HEK-293 adapted to SFM; CRE-inducible expression; cyclic AMP response elements (CREs) - HEK-293 cells; HEK-293 expression; HEK-293 expression; pTT vectors for HEK-293E cells
Plants: Magnifection; magnICON; Transgene Operating System (TOS) - antibodies;; plants and plant cells; MARs PLUS; Matrix attachment regions PLUS - plants; Concert Plant-Cell-Produced system - tobacco plant cell culture; Phyton plant cell fermentation; ExpressTec expression; ExpressPro; ExpressMab - rice and barley; antibodies
Insects: AcMNPV p35 apoptosis inhibition; Sf9P35AcV5-1 and Sf9P35AcV5-3 -; insect cells, apoptosis resistance; AF 99 insect cell line; BL-Sf-21AE-Cl 3 cell line - Insect cell lines, baculovirus hosts; Cre/loxP Recombination-Mediated Cassette Exchange (Cre/loxP RMCE) - Drosophila; (mosquitos); Drosophila expression; Drosophila melanogaster S2 cells; Drosophila-SFM.D.Mel-2 Cells; Schneider S2; Drosophila cells; S2 cells, SFM - insect cell culture; IE-1 (BmNPV 1.2 kb fragment) promoters; Bombyx mori actin promoters - insect cells; Insect cell lines - baculovirus hosts; Insect cells, per os (oral) baculovirus infection; Lymantria diapar nucleopolyhedrovirus and L. dispar 652Y (Ld652Y) cell lines -; baculovirus host cells; pIEx baculovirus vectors; hr5 enhancer; ie1 immediate early promoter - insect cells;; avoid baculovirus pathogenicity; Rhopalosiphum padi virus Internal Ribosome Entry Sequence (IRES);; Picorna-like virus IRES; Drosophila IRES - insect cells; plant cells; Tni PRO; Trichoplusia ni cell line; BAC-TO-BAC Baculovirus Expression System; baculovirus shuttle vectors;; bacmids - insect vectors produced in E. coli; BacTen System; p10 promoter vectors - insect cells; Baculovirus vectors and promoters - glycosylation; BestBac vectors; Autographa californica nuclear polyhedrosis virus (AcNPV) vectors -; insect cells; Drosophila sialyltransferases - insect cells; glycosylation; Sapphire baculovirus expression - disulfide bond formation; Vankyrin enhanced baculovirus expression vector system (VE-BEVS);; Vankyrin-enhanced cell lines (VE-CL); Indexes
Company/Organization Index
Subject Index
Primary Host/Organism Index

Biopharmaceutical Expression Systems and Genetic Engineering Technology

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