Cell-based Assays: Technologies and Global Markets
BCC Research
May 1, 2011 203 Pages - SKU: WA6404218
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An examination of how cell-based assays enable functional measures of target activation in a more relevant and informative setting when compared to biochemical assays
Analysis of global market trends, with data from 2009, estimates for 2010, and projections of compound annual growth rates (CAGRs) through 2015
A breakdown of technology platforms at the forefront of cell-based assays, including flow cytometry, microscopy and image-based, laser capture microdissection and tissue microarrays, in situ hybridization, and molecular techniques
Discussion of the market's competitive structure, mergers and acquisitions, and industry participants
Comprehensive company profiles and patent analyses.
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Additional InformationINTRODUCTION
STUDY GOALS AND OBJECTIVES
This BCC market research report, Cell-Based Assays: Technologies and Global Markets, provides a detailed overview and thorough analysis of the present and future global market for cell-based techniques. This report analyzes in detail the cell-based assays available and currently used and their markets. This report includes products in this market and detailed analyses of markets and competitive environments, cell assays markets in newly emerging regions, and instrumentation and robotics and their impact on the market. The report includes information about significant products and assays, key players, issues and trends, current market status of cell-based assays, strengths, weaknesses, opportunities, and threats facing various assays and developments already on the market, major issues involved in the research and development (R&D) of more effective cell-based approaches, for drug discovery, and absorption, distribution, metabolism, and excretion (ADME)/ toxicity assays in development and in use.
REASONS FOR DOING THE STUDY
Cell-Based assays have emerged as a more relevant alternative to biochemical assays involving the use of purified proteins. Witnessing the growth in demand for cell-Based assays, a number of cell culture and liquid-handling instruments available on the market now allow cell-based screening. The majority of compound screening programs performed by the biopharmaceutical industry rely on cell-based assays for functional measures of target activation. Label-free cellular assays are driving this paradigm forward, with their sensitivity, robustness, ease of use, and flexibility. These assays are now performed routinely throughout early drug discovery from target identification and validation to primary screening, lead identification, and lead optimization and into safety and toxicology. There is a need to understand the trends in this market, currently available assays, and latest developments for drug discovery.
SCOPE OF REPORT
The proposed report will give an update on Cell-Based Assays: Technologies and Global Markets. It will review global markets for cell-based assays and new developments and will forecast trends for use of these assays for drug discovery and safety and toxicology through 2015. Important assays, technologies and latest developments, market share by assay type, products on the market and market share by company, and statistical information for types of cancers prevalent worldwide, with special emphasis on the U.S. market. The report also includes current issues and trends affecting the industry and costs, and factors influencing demand will be discussed. The report covers products in development, new technologies, trends, alliances, and mergers. The report offers market data with respect to segments and geography. It also provides market trends with respect to drivers, restraints, and opportunities.
INTENDED AUDIENCE
This report is an exhaustive study on the worldwide cell-based assays market, giving crucial statistics and analysis on existing technologies, latest trends, market structure, market size, key drug segments, important trends in technology development, major opportunities, and market shares of key players and drugs. This report may prove crucial for the firms or investors seeking investments in the concerned sector. This report shows cell-based assays currently being used, new developments, spending trends, and revenue prospects for cell-based assays in pharma. The report provides market data for 2009 to 2015 and also covers commercial prospects for cell assays in drug research and ADME/toxicity assays.
METHODOLOGY
Both primary and secondary research methodologies were used in preparing this report. Secondary sources include books, newspapers, trade journals, white papers, industry portals, government agencies, trade associations, monitoring industry news, and developments and through access to paid databases. The base year of the report is 2009, with forecast data provided through 2015. Historical, base year and forecast data are provided for each market segment of this report. Growth rates are determined through a compilation of data, including past trends, future trends, demographics, incidence, mortality, products in R&D, and current product growth, etc.
- CHAPTER ONE: INTRODUCTION
- STUDY GOALS AND OBJECTIVES
- REASONS FOR DOING THE STUDY
- SCOPE OF REPORT
- INTENDED AUDIENCE
- METHODOLOGY
- RELATED BCC STUDIES
- ANALYST CREDENTIALS
- BCC ONLINE SERVICES
- DISCLAIMER
- CHAPTER TWO: SUMMARY
- SUMMARY
- SUMMARY TABLE GLOBAL MARKET FOR CELL-BASED ASSAYS, THROUGH 2015 ($ MILLIONS)
- SUMMARY FIGURE GLOBAL MARKET FOR CELL-BASED ASSAYS, 2009-2015 ($ MILLIONS)
- CHAPTER THREE: OVERVIEW
- DRUG DISCOVERY
- FIGURE 1 DRUG DISCOVERY AND STEPS
- TABLE 1 CELL-BASED ASSAYS AND USES
- HIGH CONTENT SCREENING (HCS) INSTRUMENTATION AND SOFTWARE
- DATA ANALYSIS
- OVERVIEW—CELL-BASED ASSAYS
- TOOLS EMERGING TO AID THE AREA OF DRUG DISCOVERY
- HIGH CONTENT IMAGING
- CELL-BASED SCREENING
- HISTORY OF HIGH-CONTENT SCREENING
- TYPES OF CELL-BASED ASSAYS
- TYPES OF TISSUE CULTURE ASSAYS
- PROLIFERATION ASSAYS
- WST (tetrazolium salt based) Reagents
- Alamar Blue Colorimetric Assay
- TABLE 2 TYPES OF CELL-BASED ASSAYS
- APOPTOSIS ASSAYS
- Caspase Assays
- DNA Fragmentation Assays
- Annexin V and Cell Permeability Assays
- Mitochondrial Assays
- Other Assays
- ASSAYS TO MEASURE GENE EXPRESSION
- ACTIVATION ASSAYS
- ASSAY PROOF OF CONCEPT FOR CELL-BASED ASSAYS
- TABLE 3 ASSAY PROOF OF CONCEPT FOR CELL--BASED ASSAYS
- CELL-BASED ASSAYS AND TECHNOLOGY TRENDS
- WHY CELL-BASED APPROACHES?
- In Vitro Homogeneous Assays
- Cell-Based Reporter Assays
- CELL-BASED ASSAYS AND FUTURE GROWTH
- TABLE 4 GLOBAL MARKET AND FORECAST FOR CELL--BASED ASSAYS, THROUGH 2015 ($ MILLIONS)
- FIGURE 2 GLOBAL MARKET AND FORECAST FOR CELL-BASED ASSAYS, 2009-2015 ($ MILLIONS)
- CELL-BASED ASSAYS FOR GPCRS
- IMMORTALIZED CELLS AND HTS
- FUTURE
- PRIMARY, STEM CELLS, AND HIGH-THROUGHPUT SCREENING
- STEM CELLS AND CELL-BASED ASSAYS
- Embryonic Stem and Cell-based Assays
- PRIMARY CELLS, STEM CELLS, AND HIGH-THROUGHPUT IMAGING
- ADVANTAGES OF MULTIPLEXED BIOLOGICAL ASSAYS
- CELL-BASED APPROACHES FOR ADME/TOX SCREENING
- Cell-Based Approaches for
(Continued)
- MARKET OPPORTUNITY
- TABLE 5 ADME AND TOXICITY SCREENING MARKET AND FORECAST, THROUGH 2015 ($ MILLIONS)
- FIGURE 3 ADME AND TOXICITY SCREENING MARKET AND FORECAST, 2009-2015 ($ MILLIONS)
- ADME and Toxicity Screening
- TABLE 6 BIOLOGICAL ASSAY SYSTEMS FOR THE EVALUATION OF CYTOCHROME P450 ENZYME ISOFORMS
- TABLE 7 HEPATOCYTE ASSAY SYSTEMS
- TABLE 8 ADME ASSAYS
- TABLE 9 COMMON TOXICITY ASSAYS
- Optical Oxygen Sensors
- Characterized Cell Lines for Cell-Based ADME and Toxicity Screening
- MULTIPLEXED CELL-BASED ASSAYS
- COMPOUND EFFECTS ON CELLS
- CELL-BASED BIOLOGICAL ASSAYS
- GENERAL BIOASSAY GUIDANCE
- HIGH-THROUGHPUT IMAGING-BASED PLATFORM FOR CELLBASED ASSAYS
- CELL ASSAYS IN TODAY’S DRUG-DISCOVERY PROCESS
- LABEL-FREE CELLULAR ASSAYS: THE RELEVANT FUTURE OF DRUG DISCOVERY
- LABEL-FREE ASSAYS AND APPLICATIONS
- BENEFITS OF LABEL-FREE ASSAYS
- TABLE 10 LABEL-FREE ASSASYS AND APPLICATIONS
- ADVANTAGES AND FUTURE
- MAJOR CHALLENGES FOR ADOPTION OF LABEL-FREE
- TECHNOLOGY
- CONCLUSIONS
- CHAPTER FOUR: TECHNOLOGIES
- FACTORS FOR CELL-BASED ASSAY DEVELOPMENT
- TABLE 11 FACTORS FOR CELL-BASED ASSAY DEVELOPMENT
- REPORTER GENE TECHNOLOGY
- TABLE 12 MAIN FEATURES OF THE DIFFERENT APPROACHES TO CELL-BASED SYSTEMS AVAILABLE FOR DRUG SCREENING
- CELL-BASED ASSAYS FOR STUDYING OF PROTEIN-PROTEIN INTERACTIONS
- CELL-BASED PROTEIN-FRAGMENT COMPLEMENTATION ASSAYS
- MEASURING CALCIUM SIGNALING
- CELL-BASED LABEL-FREE APPROACHES
- AUTOMATION AND MINIATURIZATION
- CELL PATTERNING
- CELL-BASED ASSAYS AND PHYSIOLOGICAL RELEVANCE
- CELL-BASED ASSAYS AND MULTIPLEXING
- DEVELOPING REPORTER ASSAYS
- REPORTER ASSAYS AND MULTIPLEXING
- ULTRAHIGH-THROUGHPUT SCREENING
- DEVELOPMENT OF PATHHUNTER ASSAY
- HIGH CONTENTSCREENING TECHNOLOGY
- TABLE 13 CURRENT CONFOCAL PLATFORMS
- TABLE 14 WIDEFIELD HCS PLATFORMS
- IMAGING CELLS FOR CELL-BASED ASSAYS
- MICROSCOPIC VISUALIZATION OF CELLS
- QUANTUM DOTS
- LABEL-FREE IMAGING
- ADME IN DRUG DEVELOPMENT
- TABLE 15 ADME STUDIES FOR FILING AN IND
- TABLE 16 ADME STUDIES FOR CLINICAL FILINGS
- ROLE OF ADME IN DRUG DESIGN
- PRODRUG STRATEGIES
- MOLECULAR MODELING
- SUMMARY
- LIMITATIONS OF THE USE OF CELL-BASED ASSAYS IN THE PROCESS OF RISK ASSESSMENT
- BOTTLENECKS IN CELL-BASED SCREENING
- METHODS TO IMPROVE THROUGHPUT IN CELL-BASED ASSAYS
- NEWER TECHNOLGIES
- SOLIDUS BIOSCIENCES
- SRU BIOSYSTEMS
- SIMUGEN
- MINIATURIZATION OF BIOLOGICAL ASSAYS—OVERVIEW ON MICROWELL DEVICES FOR SINGLE-CELL ANALYSES
- MICROFLUIDIC CELL-CULTURE SYSTEMS FOR DRUG RESEARCH
- CONCLUSION
- CHAPTER FIVE: COMMERCIALIZATION OF CELL-BASED ASSAYS
- CELL-BASED ASSAYS FOR DRUG DISCOVERY
- THE PARADIGM OF DRUG DISCOVERY AND CELL-BASED ASSAYS
- OPPORTUNITIES FOR MARKET ADOPTION
- TABLE 17 BIOLOGICAL APPLICATIONS FOR HCA
- Measuring Cell Proliferation
- Roche Applied Science
- BioVision
- Promega
- Millipore
- Toward Therapies with Stem and Immune Cells
- Cell-Based Screening Assays
- Euroscreen
- Arena Pharmaceuticals
- Norak Biosciences
- Orphan Receptors
- SUMMARY
- CHAPTER SIX: MARKET
- THE CELL-BASED ASSAYS MARKET
- MARKET OVERVIEW
- TABLE 18 THE GLOBAL DRUG-DISCOVERY TECHNOLOGIES MARKET, THROUGH 2015 ($ MILLIONS)
- FIGURE 4 THE GLOBAL DRUG-DISCOVERY TECHNOLOGIES MARKET, 2009-2015 ($ MILLIONS)
- CELL-BASED ASSAYS
- TABLE 19 GLOBAL MARKET FOR CELL-BASED ASSAYS, THROUGH 2015 ($ MILLIONS)
- FIGURE 5 GLOBAL MARKET FOR CELL-BASED ASSAYS, 2009-2015 ($ MILLIONS)
- MARKET NEED
- TABLE 20 LIMITATIONS OF CELL-BASED ASSAYS
- Cell-Based Assays—General Assays
- TABLE 21 CELL-BASED GENERAL ASSAYS MARKET, 2009 ($ MILLIONS)
- Specialized Cell-Based Assays
- TABLE 22 CELL-BASED SPECIALIZED ASSAYS MARKET, 2009 ($ MILLIONS)
- FIGURE 6 CELL-BASED SPECIALIZED ASSAYS MARKET, 2009 ($ MILLIONS)
- Functional Cell Assays
- TABLE 23 KEY COMPANIES
- Cell Migration Assays
- USE OF CELL-BASED ASSAYS
- TABLE 24 TOTAL HIGH CONTENT SCREENING MARKET FORECAST, THROUGH 2015 ($ MILLIONS)
- FIGURE 7 TOTAL HIGH CONTENT SCREENING MARKET FORECAST, 2009-2015 ($ MILLIONS)
- High-Content Screening Instrumentation
- High Content Screening Kits
- High Content Screening (HCS) Instrumentation Market
- TABLE 25 HIGH CONTENT SCREENING INSTRUMENTATION MARKET FORECAST, THROUGH 2015 ($ MILLIONS)
- FIGURE 8 HIGH CONTENT SCREENING INSTRUMENTATION MARKET FORECAST, 2009-2015 ($ MILLIONS)
- CHALLENGES FOR CELL-BASED ASSAYS IN THE MARKET PLACE
- Cell-Based Assays and Drug-discovery Market
- Drug-discovery Technologies Market
- TABLE 26 GLOBAL MARKET FOR CELL-BASED ASSAYS FOR DRUG DISCOVERY, THROUGH 2015 ($ MILLIONS)
- FIGURE 9 GLOBAL MARKET FOR CELL-BASED ASSAYS FOR DRUG DISCOVERY, 2009-2015 ($ MILLIONS)
- DRUG-DISCOVERY TECHNOLOGIES
- Key Companies
- ADME and Toxicology Market
- TABLE 27 GLOBAL MARKET FOR CELL-BASED ASSAYS FOR ADME, THROUGH 2015 ($ MILLIONS)
- FIGURE 10 GLOBAL MARKET FOR CELL-BASED ASSAYS FOR ADME, 2009-2015 ($ MILLIONS)
- In Vitro Predictive Toxicology
- TABLE 28 IN VITRO PREDICTIVE TOXICOLOGY ASSAYS
- ADME: Tools and Technologies
- ADME Studies for FDA Submissions
- Key Companies
- CELL-BASED ASSAYS FOR RESEARCH PURPOSES
- CELL-BASED ASSAYS AND G-PROTEIN-COUPLED RECEPTORS (GPCRS)
- TABLE 29 GPCR-TARGETING DRUGS
- Omeros—a GPCR Drug Developing Company
- GPCRs—a Potent Class of Drug Targets
- GPCRs—a Potent Class
(Continued)
- TABLE 30 ASSAY METHODS TO STUDY GPCRS
- TABLE 31 GPCR PRIMARY SCREENING ASSAYS
- TABLE 32 GLOBAL MARKET FOR GPCR SCREENING AND PROFILING, 2010 ($ MILLIONS)
- Companies and Technologies
- Key Companies
- TABLE 33 KEY PLAYERS IN THE GPCR SPACE
- Cisbio
- PerkinElmer
- Multispan
- Codex Biosolutions
- ChanTest
- Corning Life Sciences
- GPCR Drugs
- Cell-based Assays and Screening Ion Channels
- Label-free Detection
- Key Cell-Based Assays Players
- Life Technologies (Invitrogen Corporation)
- TABLE 34 INVITROGEN’S CELL--BASED TECHNOLOGIES
- CellSensor Assays
- LanthaScreen Assays
- Results of Operations
- TABLE 35 COMPARISON OF YEARS ENDED DECEMBER 31, 2010 AND 2009 ($ MILLIONS)
- Molecular Devices
- Roche
- Thermo Fisher Scientific
- TABLE 36 THERMO FISHER-REVENUE, 2009 AND 2010 ($ MILLIONS)
- CONCLUSION
- CHAPTER SEVEN: GLOBAL MARKET AND GROWTH
- WORLDWIDE MARKET FOR CELL-BASED ASSAYS
- TABLE 37 GLOBAL MARKET FOR CELL-BASED ASSAYS, BY GEOGRAPHICAL REGION, THROUGH 2015 ($ MILLIONS)
- FIGURE 11 GLOBAL MARKET FOR CELL-BASED ASSAYS-BY GEOGRAPHICAL REGION, 2009-2015 ($ MILLIONS)
- EMERGING ECONOMIES
- U.S. MARKET
- TABLE 38 U.S. MARKET FOR CELL-BASED ASSAYS, THROUGH 2015 ($ MILLIONS)
- FIGURE 12 U.S. MARKET FOR CELL-BASED ASSAYS, 2009-2015 ($ MILLIONS)
- MARKET OVERVIEW
- European Market
- TABLE 39 EUROPEAN CELL-BASED ASSAY MARKET FORECAST, THROUGH 2015 ($ MILLIONS)
- FIGURE 13 EUROPEAN CELL-BASED ASSAY MARKET FORECAST, 2009-2015 ($ MILLIONS)
- TABLE 40 EUROPEAN CELL-BASED ASSAY KITS MARKET FORECAST, THROUGH 2015 ($ MILLIONS)
- FIGURE 14 EUROPEAN CELL-BASED ASSAY KITS MARKET FORECAST, 2009-2015 ($ MILLIONS)
- Emerging Economies
- Drug Discovery in India and China
- China
- TABLE 41 CHINA DRUG-DISCOVERY OUTSOURCING MARKET FORECAST, THROUGH 2015 ($ MILLIONS)
- FIGURE 15 CHINA DRUG-DISCOVERY OUTSOURCING MARKET FORECAST 2009-2015 ($ MILLIONS)
- Challenges
- India
- TABLE 42 INDIAN DRUG-DISCOVERY MARKET FORECAST, THROUGH 2015 ($ MILLIONS)
- FIGURE 16 INDIAN DRUG-DISCOVERY MARKET FORECAST, 2009-2015 ($ MILLIONS)
- The Indian Pharma Industry—Looking Beyond Generics
- In-licensing and Custom Manufacturing
- Biosimilars
- Next Steps—the Drug-discovery Outsourcing Market
- ADVANCES IN CELL-BASED ASSAYS
- Outlook
- CHAPTER EIGHT: KEY COMPANIES
- KEY COMPANIES OUTLINED
- BD BIOSCIENCES
- BECKMAN COULTER
- CALIPER LIFE SCIENCES (CORPORATE HEADQUARTERS)
- CROS AND CELL-BASED ASSAYS
- TABLE 43 CROS AND CELL-BASED ASSAYS
- CYSBIO
- DISCOVERX
- EVOTEC AG (HEADQUARTERS)
- GE HEALTHCARE
- INVITROGEN CORPORATION
- LONZA
- MILLIPORE
- MOLECULAR DEVICES (DANAHER)
- ONCOIMMUNIN
- ORIGENE
- PERKIN ELMER
- PROMEGA CORPORATION
- STEMCELLS
- THERMO FISHER SCIENTIFIC
- TTP LABTECH
- CHAPTER NINE: LEGAL ASPECTS OF CELL-BASED ASSAYS
- THE INTELLECTUAL PROPERTY LANDSCAPE FOR CELL-BASED ASSAYS
- LATEST NEWS, ALLIANCES, AND MERGERS—2010
- Vivo Biosciences, ACEA Biosciences, and Roche to Develop New xCELLigence System Assays for Stem Cell and Cancer Research
- Roche
- DiscoveRx Corporation Acquires KINOMEscan, Previously Part of Ambit Biosciences
- Promega and Celsis In Vitro Technologies to Offer More Reliable Solutions for ADME/Tox Testing in Primary Hepatocytes
- Lonza Acquired Vivante GMP, a Viral-vaccine and Gene Therapy Company Based in Houston
- Vitro Expands HemoGenix Alliance to Include Cell-Based Testing for Liver Toxicity
- Tools for Stem Cell and Drug Development
- MERGERS
- Ligand and Neurogen Amend Merger Agreement
- Platypus Licenses Cell Exclusion Zone Technology to Cell Biolabs
- Ion Channel and GPCR Screening Services and Products on March 21, 2011
- Label-Free Technologies
- PerkinElmer Launches the EnSpire Multimode Plate Reader with Label-free Detection Technology for Drugdiscovery Research
- SUMMARY AND OUTLOOK
- BIBLIOGRAPHY
- BIBLIOGRAPHY
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