Biologic Imaging Reagents: Technologies and Global Markets


January 1, 2013
213 Pages - SKU: WA4936290
License type:
Countries covered: Global

This report provides:

An overview of the global market for biologic imaging reagents, including those that are commercial or likely to be commercialized within the next five years

Analyses of global market trends, with data from 2011, estimates for 2012, and projections of compound annual growth rates (CAGRs) through 2017

Coverage of fluorescent probes and dyes; imaging nanomaterials (including quantum dots and other nanoparticles); fluorescent proteins; supermolecules; contrast reagents for MRI, X-ray and ultrasound; and imaging radiopharmaceuticals

Analysis of each technology to determine its market status and impact on future market segments

Discussion of imaging reagent producers and the industry structure in specialized segments

Reviews of industry alliances and acquisitions, and the use of biologic imaging reagents in key diagnostics and R&D tools platforms, including microarrays, lab-on-a-chip devices, DNA sequencing, PCR and cellular analysis

Comprehensive company profiles of major players in the industry.


Additional Information

INTRODUCTION

STUDY GOALS AND OBJECTIVES

BCC’s goal for this study was to determine the global market and future demand growth for biologic imaging reagents over a five-year period from 2012 to 2017. Our particular interest is to characterize and quantify the biologic imaging reagents market potential by technology, reagent type and end user market. We also evaluate future growth opportunities in emerging biologic imaging reagents including quantum dots, nanoparticles, fluorescent proteins and supermolecules.

Imaging reagent types covered include fluorescent probes and dyes; fluorescent proteins; nanoparticles; magnetic resonance imaging, ultrasound and X-ray contrast reagents; and imaging radiopharmaceuticals.

Our key objective was to present a comprehensive discussion of where the state-of-the-art is in biologic imaging reagents and forecast the future commercial potential for the key market segments. This discussion will provide a basis for companies to make strategic choices about developing new products and markets, or employing biologic imaging reagents. The study will benefit reagent and instrument manufacturers, users of biologic imaging reagents, medical instrument companies, life sciences tools companies, diagnostic and drug manufacturers, biotechnology companies, and developers of nanotechnologies.

REASONS FOR DOING THE STUDY

Biologic imaging reagents play an important role in the medical, pharmaceutical, diagnostic, biotechnology and life sciences tools industries. Imaging and detection technologies are used extensively in medicine, biotechnology and pharmaceutical research. Traditional imaging techniques, such as X-ray, computer tomography (CT), ultrasound (US), magnetic resonance imaging (MRI) and nuclear medicine (NM), mainly analyze anatomy and morphology and cannot detect changes at the molecular level. However, new developments in biotechnology allow us to image at the cellular and molecular level, paving the way for earlier diagnosis and treatment of disease. Biologic imaging reagents play a critical role in this medical revolution.

At the same time, ongoing advances in genomics, proteomics and cellular analysis are aided by imaging technologies, including fluorescent dyes and probes, quantum dot nanoparticles, and fluorescent proteins. Growth in technologies such as biochips, DNA sequencing and polymerase chain reaction (PCR) relies on sensitive biologic fluorescent imaging reagents.

Advances in technologies that are used in biologic imaging reagents are also moving forward at a rapid pace. These technologies include nanotechnology, biologic targeting, microfluidics, supramolecular chemistry and protein engineering. Rapid developments across a number of technology fields promise to change the biologic imaging industry by enabling novel imaging reagents and unique market opportunities. This report analyzes these developments and their impact on the future markets for biologic imaging reagents.

Given these market and technology dynamics, it is especially timely to examine the biologic imaging reagents market.

CONTRIBUTION OF THE STUDY AND FOR WHOM

We have compiled a study of existing and future imaging reagent technologies that will be commercially important in the major end user segments, including life science research tools, drug discovery and development, and diagnostics.

We present the various imaging reagent technologies, including fluorescent probes and dyes, nanomaterials, fluorescent proteins, contrast reagents, and imaging radiopharmaceuticals. We also examine the industry growth driving forces; product types; market applications; companies and industry alliances and acquisitions; future market potential; and product sales forecasts for the period 2012 through 2017. We project the future use of biologic imaging reagents in the main end user segments and by technology.

This study will be of particular interest to life science research tools suppliers, pharmaceutical manufacturers, diagnostics, biotechnology, genomics, proteomics, nanotechnology and supramolecular companies. It will also be of interest to companies making products for medical imaging, microarrays, lab on a chip, polymerase chain reaction, molecular diagnostics assays, cell-based assays, and fluorescence activated cell sorting (FACS) as well as medical researchers and clinicians.

SCOPE AND FORMAT

The study scope includes the biologic imaging reagents that are commercial or likely to be commercialized within the next five years. Fluorescent probes and dyes; imaging nanomaterials (including quantum dots and other nanoparticles); fluorescent proteins; contrast reagents for MRI, X-ray and ultrasound; and imaging radiopharmaceuticals are studied. Both the in-vivo and in-vitro market segments are included. Each technology is analyzed to determine its market status, impact on future market segments and forecasted growth from 2012 through 2017. Technology status and market driving forces are also discussed.

BCC examines imaging reagent producers and the industry structure in specialized segments of the industry. We also review industry alliances and acquisitions, and the use of biologic imaging reagents in key diagnostics and research and development (R&D) tools platforms, including microarrays, lab-on-a-chip devices, DNA sequencing, PCR and cellular analysis. The markets for novel biologic imaging reagent applications, including targeted multifunctional and hybrid therapeutic reagents, are analyzed, and the main companies in these fields are highlighted.

METHODOLOGY

BCC talked to key users and producers in the end user market segments and technology fields that will be commercially important during the next five years. Extensive secondary market research was performed.

Based on our analysis, we project the future applications of biologic imaging reagents in the major end user market segments and by technology type and forecast sales revenues for 2012 through 2017.
CHAPTER 1 INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
CONTRIBUTION OF THE STUDY AND FOR WHOM
SCOPE AND FORMAT
METHODOLOGY
INFORMATION SOURCES
RELATED BCC REPORTS
ANALYST CREDENTIALS
BCC RESEARCH ONLINE SERVICES
DISCLAIMER
CHAPTER 2 EXECUTIVE SUMMARY
SUMMARY TABLE GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS BY CLASS, THROUGH 2017 ($ MILLIONS)
SUMMARY FIGURE GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS BY CLASS, THROUGH 2017 ($ MILLIONS)
CHAPTER 3 OVERVIEW
INTRODUCTION
REPORT SCOPE
TABLE 1 SCOPE OF THIS REPORT
MARKET POTENTIAL
TABLE 2 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY TECHNOLOGY CLASS, THROUGH 2017 ($ MILLIONS)
TABLE 3 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS BY END USER MARKET, THROUGH 2017 ($ MILLIONS)
INDUSTRY GROWTH DRIVING FORCES
TABLE 4 BIOLOGIC IMAGING REAGENTS GROWTH DRIVING FORCES
LIFE CYCLE STATUS
TABLE 5 LIFE CYCLE STAGE OF BIOLOGIC IMAGING REAGENTS
BIOLOGIC IMAGING REAGENTS INDUSTRY
TABLE 6 BIOLOGIC IMAGING REAGENTS KEY COMPANIES
CHAPTER 4 BIOLOGIC IMAGING TECHNOLOGIES
IMAGING REAGENT TYPES
TABLE 7 KEY BIOLOGIC IMAGING REAGENT TYPES
IN-VIVO IMAGING MODALITIES
TABLE 8 IN-VIVO IMAGING MODALITIES
TABLE 9 COMPARISON OF IN-VIVO IMAGING MODALITIES
MOLECULAR IMAGING
IN-VITRO IMAGING/DETECTION
TABLE 10 APPLICATIONS OF IN-VITRO BIOLOGIC IMAGING
TRENDS IN IN-VIVO IMAGING
TABLE 11 KEY TECHNOLOGY DRIVERS FOR IN-VIVO IMAGING REAGENTS
BIOLOGIC IMAGING REAGENTS TECHNOLOGIES
NANOPARTICLES
TABLE 12 NANOPARTICLES IN IMAGING APPLICATIONS
FLUORESCENT DYES AND PROBES
TABLE 13 FLUORESCENT DYES AND PROBES
TABLE 14 GENERAL ADVANTAGES OF FLUORESCENCE LABELS
TABLE 15 FLUORESCENT DYE PERFORMANCE CRITERIA
FLUORESCENT PROTEINS
TABLE 16 TYPES OF FLUORESCENT PROTEINS
Genetically Engineered Fluorescent Proteins
TABLE 17 PHOTOACTIVABLE AND PHOTOCONVERTIBLE FLUORESCENT PROTEIN TYPES
Engineered Fluorescent Cell Lines
Emerging Fluorescent Protein Applications
TABLE 18 EMERGING APPLICATIONS OF FLUORESCENT PROTEINS
Comparison of Fluorescent Proteins with Fluorescent Dyes
TABLE 19 FLUORESCENT PROTEINS VERSUS DYES
Technology Challenges
TABLE 20 TECHNOLOGY CHALLENGES FOR FLUORESCENT PROTEINS
SUPERMOLECULES
TABLE 21 CLASSIFICATION OF IMAGING SUPERMOLECULES
QUANTUM DOTS
TABLE 22 COMPARISON OF QUANTUM DOTS, FLUORESCENT DYES AND FLUORESCENT
PROTEINS
FIGURE 1 QUANTUM DOT SPECTRA (INTENSITY)
FIGURE 2 FLUORESCENT DYE SPECTRA
TABLE 23 BIOLOGIC IMAGING APPLICATIONS OF QUANTUM DOTS
RADIOPHARMACEUTICAL IMAGING REAGENTS
CONTRAST IMAGING REAGENTS
TABLE 24 MICROBUBBLE ULTRASOUND IMAGING AGENTS
EMERGING CLASSES OF IMAGING REAGENTS
COMPONENTS OF ADVANCED IMAGING REAGENT TECHNOLOGY
FIGURE 3 THREE COMPONENTS OF ADVANCED IMAGING REAGENT TECHNOLOGY
ADVANCED IMAGING REAGENT FUNCTIONS
TABLE 25 EMERGING ADVANCED BIOLOGIC IMAGING REAGENT FUNCTIONS
Dual Modality Reagents
Multifunctional Reagents
Multiplexed Reagents
BIOLOGIC IMAGING REAGENTS MANUFACTURING COSTS
FIGURE 4 ESTIMATED MANUFACTURING COSTS OF IMAGING REAGENTS CLASSES ($/GRAM)
COMPARISON OF IMAGING REAGENT TECHNOLOGY PLATFORMS
TABLE 26 LIFE CYCLE OF BIOLOGIC IMAGING REAGENT TECHNOLOGIES
TABLE 27 TECHNOLOGY STATUS OF BIOLOGIC IMAGING REAGENT PLATFORMS
TABLE 28 TECHNOLOGY CHALLENGES FOR IN-VIVO IMAGING REAGENTS
CHAPTER 5 BIOLOGIC IMAGING REAGENTS APPLICATIONS
OVERVIEW
TABLE 29 BIOLOGIC IMAGING REAGENTS APPLICATIONS
TABLE 30 SIGNIFICANCE OF BIOLOGIC IMAGING REAGENTS TO LIFE SCIENCES AND MEDICAL INDUSTRIES
TABLE 31 USE OF BIOLOGIC IMAGING REAGENTS BY MARKET SEGMENT
TABLE 32 APPLICATIONS WITHIN MARKET SEGMENTS
RESEARCH AND DEVELOPMENT
TABLE 33 R&D TOOLS IMAGING REAGENTS
TABLE 34 EMERGING APPLICATIONS FOR BIOLOGIC IMAGING REAGENTS IN R&D TOOLS
DRUG DISCOVERY AND DEVELOPMENT
TABLE 35 IMAGING APPLICATIONS IN DRUG DISCOVERY AND DEVELOPMENT
INFLUENCE OF IMAGING TECHNOLOGY ON DRUG DEVELOPMENT
ATTRITION RATE OF LEAD DRUG COMPOUNDS
FIGURE 5 ATTRITION RATE OF DRUG CANDIDATES DURING DRUG DEVELOPMENT
FLUORESCENT PROTEIN APPLICATIONS IN DRUG DISCOVERY
IN-VIVO SMALL ANIMAL IMAGING APPLICATIONS
TABLE 36 COMPARISON OF SMALL ANIMAL IMAGING MODALITIES
TABLE 37 OUTSTANDING MARKET NEEDS FOR SMALL ANIMAL IMAGING
DIAGNOSTICS
INTRODUCTION
TABLE 38 DIAGNOSTICS IMAGING REAGENTS APPLICATIONS
DIAGNOSTIC APPLICATIONS OF IMAGING REAGENTS
TABLE 39 DIAGNOSTIC APPLICATIONS OF SELECTED IMAGING REAGENTS
Fluorescent Dyes, Probes and Tags
Nanoparticles
Supermolecules
Imaging Radiopharmaceuticals
Contrast Reagents
MOLECULAR IMAGING
TABLE 40 CLINICAL APPLICATIONS FOR IN VIVO MOLECULAR IMAGING
CHAPTER 6 BIOLOGIC IMAGING REAGENTS INDUSTRY STRUCTURE
INNOVATION WITHIN THE IMAGING REAGENT INDUSTRY
STRATEGIC ALLIANCES
TABLE 41 BIOLOGIC IMAGING REAGENT STRATEGIC ALLIANCES, 2010-2012
INDUSTRY ACQUISITIONS
TABLE 42 BIOLOGIC IMAGING REAGENTS INDUSTRY ACQUISITIONS, 2010–2012
MEDICAL IMAGING INSTRUMENT SECTOR
TABLE 43 COMPETITIVE FOCUS OF MAJOR MEDICAL IMAGING COMPANIES
FLUORESCENT DYES AND PROBES INDUSTRY STRUCTURE
TABLE 44 FLUORESCENT IMAGING REAGENTS COMPETITORS
QUANTUM DOTS INDUSTRY
TABLE 45 QUANTUM DOT COMPETITORS
CONTRAST REAGENTS INDUSTRY
TABLE 46 CONTRAST AGENTS KEY COMPETITORS
RADIOPHARMACEUTICALS INDUSTRY
TABLE 47 IMAGING RADIOPHARMACEUTICALS COMPANIES
TABLE 48 RADIOPHARMACEUTICALS BIOTECHNOLOGY COMPANIES
RADIOACTIVE ISOTOPES SUPPLY
SMALL ANIMAL IN-VIVO IMAGING INDUSTRY
TABLE 49 SMALL ANIMAL IN-VIVO FUNCTIONAL IMAGING REAGENT COMPETITORS
CARDIAC IMAGING INDUSTRY
TABLE 50 CARDIAC IMAGING REAGENT COMPETITIVE SPACE
PROSTATE CANCER IMAGING INDUSTRY
TABLE 51 PROSTATE CANCER IMAGING AGENT COMPETITION
ALZHEIMER'S DISEASE PET IMAGING INDUSTRY
TABLE 52 ALZHEIMER’S DISEASE PET IMAGING AGENT COMPETITIVE SPACE
CHAPTER 7 BIOLOGIC IMAGING REAGENTS MARKETS
GROWTH DRIVING FORCES
TABLE 53 BIOLOGIC IMAGING REAGENTS GROWTH DRIVING FORCES
MARKET OVERVIEW
TABLE 54 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY APPLICATION, THROUGH 2017 ($ MILLIONS)
TABLE 55 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY TECHNOLOGY CLASS, THROUGH 2017 ($ MILLIONS)
TABLE 56 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS MARKET, BY END USE, THROUGH 2017 ($ MILLIONS)
TABLE 57 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY END USER MARKET, THROUGH 2017 ($ MILLIONS)
TABLE 58 GLOBAL VALUE OF BIOLOGIC REAGENTS MARKET, BY MODALITY, THROUGH 2017 ($ MILLIONS)
CONTRAST REAGENTS MARKET
TABLE 59 GLOBAL VALUE OF CONTRAST REAGENTS MARKET, BY MODALITY, THROUGH 2017 ($ MILLIONS)
MRI REAGENTS MARKET
TABLE 60 GLOBAL VALUE OF MRI REAGENTS MARKET, BY TYPE, THROUGH 2017 ($ MILLIONS)
TABLE 61 GLOBAL VALUE OF GD-CHELATE MRI REAGENTS BY PRODUCT, THROUGH 2017 ($ MILLIONS)
TABLE 62 GLOBAL VALUE OF MRI NON-GD CHELATE REAGENTS, THROUGH 2017 ($ MILLIONS)
TABLE 63 GLOBAL SALES OF MRI CONTRAST REAGENTS BY PROCEDURE, THROUGH 2017 ($ MILLIONS)
ULTRASOUND REAGENTS MARKET
TABLE 64 GLOBAL VALUE OF MICROBUBBLE ULTRASOUND REAGENTS MARKET, BY TYPE, THROUGH 2017 ($ MILLIONS)
X-RAY/CT REAGENTS MARKET
TABLE 65 GLOBAL VALUE OF X-RAY/CT REAGENTS MARKET, BY TYPE, THROUGH 2017 ($ MILLIONS)
TABLE 66 GLOBAL VALUE OF X-RAY/CT REAGENTS MARKET, BY INDICATION, THROUGH 2017 ($ MILLIONS)
RADIOPHARMACEUTICALS MARKET
TABLE 67 GLOBAL VALUE OF RADIOPHARMACEUTICALS IMAGING REAGENTS MARKET, BY SCANNER TYPE, THROUGH 2017 ($ MILLIONS)
TABLE 68 GLOBAL VALUE OF RADIOPHARMACEUTICALS IMAGING REAGENTS MARKET, BY ISOTOPE, THROUGH 2017 ($ MILLIONS)
TABLE 69 GLOBAL VALUE OF RADIOPHARMACEUTICALS IMAGING REAGENTS MARKET, BY INDICATION, THROUGH 2017 ($ MILLIONS)
TABLE 70 GLOBAL VALUE OF RADIOPHARMACEUTICALS IMAGING REAGENTS MARKET, BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS)
SPECT RADIOPHARMACEUTICALS MARKET
TABLE 71 GLOBAL VALUE OF SPECT IMAGING REAGENTS MARKET, BY ISOTOPE, THROUGH 2017 ($ MILLIONS)
TABLE 72 HALF LIFE OF COMMON PET AND SPECT ISOTOPES
TABLE 73 GLOBAL VALUE OF SPECT IMAGING REAGENTS MARKET, BY INDICATION, THROUGH 2017 ($ MILLIONS)
TABLE 74 SENTINEL NODE DETECTION RADIOPHARMACEUTICALS PRODUCERS
TABLE 75 GLOBAL VALUE OF SPECT IMAGING REAGENTS MARKET, BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS)
PET RADIOPHARMACEUTICALS MARKET
TABLE 76 GLOBAL VALUE OF PET IMAGING REAGENTS MARKET, BY ISOTOPE, THROUGH 2017 ($ MILLIONS)
TABLE 77 GLOBAL VALUE OF PET IMAGING REAGENTS MARKET, BY INDICATION, THROUGH 2017 ($ MILLIONS)
TABLE 78 GLOBAL VALUE OF PET IMAGING REAGENTS MARKET, BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS)
OPTICAL IMAGING REAGENTS MARKET
TABLE 79 GLOBAL VALUE OF OPTICAL FLUORESCENT IMAGING REAGENTS MARKET, BY APPLICATION, THROUGH 2017 ($ MILLIONS)
TABLE 80 GLOBAL VALUE OF IN-VITRO OPTICAL FLUORESCENT IMAGING REAGENTS MARKET, BY ASSAY TYPE, THROUGH 2017 ($ MILLIONS)
TABLE 81 GLOBAL VALUE OF GENOMICS IN-VITRO OPTICAL FLUORESCENT IMAGING REAGENTS MARKET, BY ASSAY TYPE, THROUGH 2017 ($ MILLIONS)
TABLE 82 GLOBAL VALUE OF PROTEOMICS IN-VITRO OPTICAL FLUORESCENT IMAGING REAGENTS MARKET, BY ASSAY TYPE, THROUGH 2017 ($ MILLIONS)
TABLE 83 GLOBAL VALUE OF CELLULAR ANALYSIS IN-VITRO OPTICAL FLUORESCENT IMAGING REAGENTS MARKET BY ASSAY TYPE, THROUGH 2017 ($ MILLIONS)
TABLE 84 GLOBAL VALUE OF OPTICAL FLUORESCENT IMAGING REAGENTS, BY END USE, THROUGH 2017 ($ MILLIONS)
TABLE 85 GLOBAL VALUE OF IN-VITRO OPTICAL IMAGING REAGENTS, BY TYPE, THROUGH 2017 ($ MILLIONS)
GEOGRAPHICAL MARKET
TABLE 86 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY GEOGRAPHY, THROUGH 2017 ($ MILLIONS)
CHAPTER 8 PATENT STATUS
IMAGING REAGENTS PATENTS BY SELECTED TECHNOLOGY
TABLE 87 NUMBER OF PATENTS BY TECHNOLOGY, 2001-2011
FLUORESCENCE REAGENTS
TABLE 88 FLUORESCENCE REAGENTS PATENT ASSIGNEES BY COMPANY (NO.)
FLUORESCENT PROTEINS
TABLE 89 FLUORESCENT PROTEIN PATENT ASSIGNEES BY COMPANY (NO.)
QUANTUM DOTS
TABLE 90 QUANTUM DOTS PATENT ASSIGNEES BY COMPANY (NO.)
GOLD NANOPARTICLES
TABLE 91 GOLD NANOPARTICLE PATENT ASSIGNEES BY COMPANY (NO.)
SUMMARY OF PATENTS BY COMPANY
TABLE 92 NUMBER OF PATENTS, BY COMPANY, FOR FOUR IMAGING REAGENT MARKET SEGMENTS
CHAPTER 9 COMPANY PROFILES
ABT MOLECULAR IMAGING INC.
ABX ADVANCED BIOCHEMICAL COMPOUNDS GMBH
ACTIVE MOTIF CHROMEON GMBH
ACUSPHERE INC.
ADVANCED ACCELERATOR APPLICATIONS SA
ADVANCED PROTEOME THERAPEUTICS INC.
ADVANCED RESEARCH TECHNOLOGIES, INC.
AFFIBODY AB
TABLE 93 AFFIBODY ALLIANCES
AGENIX LTD.
ALSERES PHARMACEUTICALS INC.
ALZHYME PTY LTD.
AMAG PHARMACEUTICALS INC.
AMERICAN ELEMENTS
AMERICAN DYE SOURCE INC.
ANASPEC INC.
ANTICANCER INC.
APOSENSE
AREVA
ASTELLAS PHARMA INC.
ASTRAZENECA LTD.
ATREUS PHARMACEUTICALS CORPORATION
ATTO-TEC GMBH
AXXAM SPA
BAYER HEALTHCARE AG
BBI INTERNATIONAL
BD
BECKMAN COULTER INC.
BETAPLUS RADIOPHARMACEUTIALS LLC
BIOFORCE NANOSCIENCES HOLDINGS INC.
BIOMODA INC.
BIOSCAN INC.
BIOSEARCH TECHNOLOGIES INC.
BIOSCEPTRE INTERNATIONAL LIMITED
BIOTIUM INC.
BIOVISION, INC.
BRACCO IMAGING S.P.A.
CAPSULUTION PHARMA AG
CARDINAL HEALTH
CARESTREAM HEALTH INC.
CELLCYTE GENETICS
CELLPOINT LLC.
CHEMATECH SAS
CHEMICELL GMBH
CHINA MEDICAL TECHNOLOGIES INC.
CHROMOTEK GMBH
CISBIO BIOASSAYS
COVALYS BIOSCIENCES AG
COVIDIEN PLC
CYTODIAGNOSTICS
DAIICHI SANKYO CO. LTD.
DENDRITECH INC.
DENOVO BIOLABELS GMBH
EBIOSCIENCE INC.
ECKERT & ZIEGLER AG
ELI LILLY AND COMPANY
ERIGAL LIMITED
ESTECH PHARMA CO. LTD.
EVIDENT TECHNOLOGIES
EVROGEN
FERROPHARM GMBH
FLUOPTICS
FLUOROPHARMA INC.
TABLE 94 FLUORPHARMA PET IMAGING REAGENT PIPELINE
FUJI PHARMA CO. LTD.
GE HEALTHCARE
GENISPHERE LLC
GUERBET
IASON GMBH
IMAGINAB INC.
IMMUNOMEDICS INC.
INDEC BIOSYSTEMS
INNOPROT
INVISAGE INC.
IPSEN GROUP
ISO-TEX DIAGNOSTICS INC.
JAZZ PHARMACEUTICALS PLC
J.B. CHEMICALS & PHARMACEUTICALS LTD.
JOHNSON & JOHNSON
JUBILANT LIFE SCIENCES LTD.
KEREOS INC.
TABLE 95 KEREOS IMAGING REAGENTS PIPELINE
KPL INC.
LAB21 LTD
LABORATOIRES CYCLOPHARMA
LANTHEUS MEDICAL IMAGING
TABLE 96 LANTHEUS DIAGNOSTIC IMAGING PIPELINE
LIFE TECHNOLOGIES INC.
LUMIPHORE INC.
LUNA NANOWORKS
MARINPHARM GMBH
MARVAL BIOSCIENCES INC.
MBL INTERNATIONAL
MEDI RADIOPHARMA LTD
MELLITECH SAS
MOBIOTEC GMBH
MOLECULAR INSIGHT PHARMACEUTICALS
TABLE 97 MOLECULAR INSIGHT IMAGING REAGENTS PIPELINE
MOLECULAR TARGETING TECHNOLOGIES INC.
NANOAXIS LLC
NANOCO TECHNOLOGIES LTD.
NANO-H SAS
NANOPROBES INC.
NANOSCAN IMAGING LLC
TABLE 98 LYMPH NODE STATUS
NANOSPECTRA BIOSCIENCES
NANOSPHERE INC.
TABLE 99 NANOSPHERE GOLD IMAGING REAGENTS PIPELINE
NAVIDEA BIOPHARMACEUTICALS
TABLE 100 NAVIDEA PIPELINE
NN-LABS LLC
NORDION INC.
NOVELOS THERAPEUTICS INC.
NUVIEW LIFE SCIENCES
OCEAN NANOTECH LLC
OCTREOPHARM SCIENCES GMBH
OXFORD CONTRAST MOLECULAR DIAGNOSTICS
OXONICA INC.
PERKINELMER INC.
PHARMALUCENCE INC.
PHILIPS HEALTHCARE
PHOTOCURE ASA
PIRAMAL HEALTHCARE LTD.
PRINCIPIO, INC.
PROMEGA CORPORATION
QUANTUM MATERIALS CORPORATION
RAPIDSCAN PHARMA SOLUTIONS INC.
READE ADVANCED MATERIALS
SIEMENS AG
SIRIGEN LTD.
SIGNALOMICS GMBH
SPAGO IMAGING AB
SOFIE BIOSCIENCES
TAKARA BIO INC.
TAEJOON PHARMA CO. LTD.
TARGESON INC.
THERAGNOSTIC TECHNOLOGIES INC.
THERMO FISHER SCIENTIFIC
TK-SIGNAL LTD.
TOP SRL
WILEX AG
TABLE 101 WILEX CLINICAL PRODUCT PIPELINE

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