Apoptosis: New Growth Opportunities
BCC Research
September 1, 2000 166 Pages - SKU: WA275058
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Apoptosis is a process through which cells initiate their own deaths. Also called cellular suicide and programmed cell death, apoptosis is vital to the development and survival of many organisms, because it allows an organism to rid itself of damaged or unnecessary cells. However, when genetic mutations or other problems alter apoptotic processes, diseases can result. For example, certain mutations can render cells unable to initiate apoptosis -- a condition that can lead to uncontrolled cellular proliferation and cancer. Alternatively, mutations that do not allow apoptosis to stop may play a role in the pathogenesis of Alzheimer's disease. Additionally, some viruses inactivate genes that control apoptosis, and force cells to remain alive and in service to viral reproduction.
This report discusses pharmaceutical and technological applications of apoptosis. This field promises to bring important new treatments for cancers, neurological conditions, cardiac problems, and other diseases. The report also addresses the state of the market for apoptosis-related research kits and reagents. It also analyzes the latest research on the subject, examines investments in drug development, and forecasts worldwide sales of drugs, kits, and reagents. Market forecasts project sales to the year 2005.
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Introduction
- Study Goals And Objectives
- Reasons For Doing The Study
- Audience For The Report
- Scope And Format
- Methodology And Information Sources
- Bcc Information And Related Bcc Studies
- Bcc On-Line Services
- Disclaimer
Executive Summary
- Overall Apoptosis Market To
- Forecasts
Overview
History Of Apoptosis Research
Genes And Proteins Involved In Apoptosis
- Cytochrome C
- The Bcl- Family
- P
- The Caspase Family
- Fas/Cd/Apo-
- Cards (Caspase Recruitment Domains)
- Mdm
- Iaps
- Trail (Apo- Ligand)
- Granzymes
Apoptosis-Related Products: Market Development
- Annexin-V
- Dna Fragmentation Kits Detect The Breakup Of Dna
- The Future Of Apoptosis-Related Research Kits, Reagents, And Pharmaceuticals
- Principal Market Forces
- Selected Bibliography
FDA Regulations For Developing And Marketing New Pharmaceutical Agents
- Introduction
- Preclinical Testing And Submitting An Ind
- Clinical Trials
- Submitting An Nda
- Post-FDA Approval
- Conclusions
Apoptosis Markets: Apoptosis And Cancer Therapy
- Background On Cancer Therapy
- Background On Apoptosis-Related Cancer Therapy
- Aptosyn (Exisulind): Cell Pathways, Inc.
- Aptosyn: Background Information
- Aptosyn: Applications
- Aptosyn: Forecasts
- Cell Pathways: Collaborations And Alliances
- Cp-: Cell Pathways, Inc.
- Cp-: Background Information And Applications
- Cell Pathways: Patent Portfolio
- Genasense: Genta, Inc.
- Genasense: Background
- Genasense: Applications
- Genasense: Stastics And Forecasts
- Genta: Patent Portfolio
- Ci-: Onyx Pharmaceuticals
- Ci-: Background
- Ci-: Applications
- Onyx Pharmaceuticals: Patent Portfolio
- Ci-: Forecasts
- Irofulven (Formerly Mgi-): Mgi Pharma
- Irofulven: Background
- Irofulven: Applications And Forecasts
- Mgi Pharma: Collaborations And Alliances
- Mgi Pharma: Patent Portfolio
- Sch (Rad/P): Schering-Plough
- Sch : Background
- Sch : Applications
- Sch: Forecasts
- RPR/INGN : Introgen Therapeutics, Inc.
- INGN : Background
- Introgen: Collaborations
- Introgen: Patent Position
- Introgen: Forecasts
- Sti-: Novartis
- Sti-: Background
- Sti-: Forecasts
- Miscellaneous Agents
- Onconase (Alfacell Corporation): Background
- Theragyn (Antisoma, Plc): Background
- Mx (Maxia Pharmaceuticals): Background
- Pivanex (Titan Pharmaceuticals, Inc.): Background
- Apomine (Ilex Oncology): Background
- NV- (Novogen, Inc.): Background
- Apomate (Theseus Imaging Corp.): Background
- Rubitecan (Supergen, Inc.): Background
- ME (Entremed, Inc.): Background
Apoptosis And Neurodegenerative Disorders
- Background
- Agents In Clinical Trials And In Preclinical Development
- Dp-B (D-Pharm, Inc.): Background
- Caspase Inhibitors (Idun Pharmaceuticals, Inc.): Background
- Mp (Alexion Pharmaceuticals): Background
- Caspase Inhibitors (Vertex Pharmaceuticals, Inc.): Background
Apoptosis And Cardiovascular Disorders
- Background
- Agents In Clinical Trials And In Preclinical Development
- Hk- Cp-Cardiosol (Lxr Biotechnology, Inc): Background
- Antrin (Pharmacyclics, Inc.): Background
- Vas (Vasogen, Inc.): Background
- Apomate (Theseus Imaging Corp.): Background
- Cv (Cytovia, Inc.): Background
- Caspase Inhibitors (Idun Pharmaceuticals, Inc.): Background
Apoptosis Markets: Research Kits And Reagents
- Background
- The Caspase Family
- Background On Caspases
- Market Trends
- Research Uses Of Caspase Products
- Caspase Inhibitors And Substrates
- Inhibitors
- Substrates
- Annexin-V
- Antibodies For Research Use
- Jc-
- Background
Apoptosis-Related Patents
- Apoptosis Patent Trends
- Apoptosis Technology Patents
- Patent Assignees
Appendix I: Pharmaceutical And Reagent Companies Engaged In Apoptosis Research
- A.G. Scientific
- Alexis Corporation
- Alfacell Corporation
- American Peptide Company
- Anaspec
- Ancell Corporation
- Antisoma Plc
- Apoptogen, Inc.
- Apoptosis Technology, Inc.
- Arcaris, Inc.
- Ariad Pharmaceuticals, Inc.
- Axonyx, Inc.
- Bionostics, Inc.
- Biosource International
- Biovision, Inc.
- Caltag, Inc.
- Canji, Inc. (Schering-Pough)
- Carbomed, Inc.
- Caspases.Com
- Cell Pathways, Inc.
- Cel-Sci Corporation
- Chemicon International, Inc.
- Clontech Laboratories, Inc.
- Cytovia, Inc.
- D-Pharm, Inc.
- Enzyme Systems
- Exalpha Biologicals
- Geno Technology, Inc.
- Genta, Inc.
- Hybridon
- Idun Pharmaceuticals, Inc.
- Ilex Oncology
- Immunex Corporation
- Intergen Company
- Introgen Therapeutics, Inc.
- Invivogen
- Kamiya Biomedical Company
- Kinetek Pharmaceuticals, Inc.
- Lab Vision Corporation
- Lxr Biotechnology Inc.
- Maxia Pharmaceuticals, Inc.
- Medical & Biological Laboratories Co., Ltd.
- Mgi Pharma, Inc.
- Millennium Pharmaceuticals, Inc.
- Molecular Probes
- Nexins Research
- Novogen, Inc.
- Oncogene Research Products
- Oncoimmunin, Inc.
- Onyx Pharmaceuticals, Inc.
- Oxford Biomedical Research
- Panvera Corporation
- Peninsula Laboratories Inc.
- Pentagenic Pharmaceuticals, Inc.
- Bd Pharmingen
- Promega Corporation
- Quality Controlled Biochemicals, Inc.
- R & D Systems, Inc.
- Research Diagnostics, Inc.
- Rhône-Poulenc Rorer Inc.
- Roche Molecular Biochemicals
- Santa Cruz Biotechnology, Inc.
- Serotec, Inc.
- Sigma-Aldrich Corporation
- Southern Biotech. Associates, Inc
- Stratagene, Inc
- Stressgen Biotechnologies Corp.
- Theseus Imaging Corp.
- Bd Transduction Laboratories
- Trevigen, Inc.
- United States Biological
- Upstate Biotechnology, Inc.
- Vertex Pharmaceuticals, Inc.
- Zymed Laboratories, Inc.
Appendix II Contact Information For Non-Profit Entities Mentioned In This Report
- Advanced Research And Technology Institute
- Alton Ochsner Medical Foundation
- Arch Development Corporation
- Baylor College Of Medicine
- The Burnham Institute (Formerly The La Jolla Cancer Research Foundation)
- Cornell Research Foundation, Inc
- Cold Spring Harbor Laboratory
- Columbia Innovation Enterprise (Cie)
- Dana-Farber Cancer Institute
- Dartmouth College
- Duke University
- Fox Chase Cancer Center
- Harvard University
- Johns Hopkins University
- Ludwig Inst For Cancer Research
- Massachusetts Institute Of Technology
- Memorial Sloan-Kettering Cancer Center
- Sir Mortimer B. Davis Jewish General Hospital
- National Jewish Medical And Research Center
- New York University
- Oregon Health Sciences University
- Osaka Bioscience Institute
- Princeton University
- Rockefeller University
- Rutgers University
- Saint Elizabeth's Medical Center Of Boston
- Saint Louis University Health Sciences Center
- The Scripps Institute
- Sloan-Kettering Cancer Center
- Stanford University
- Texas Heart Institute
- Thomas Jefferson University
- University Of Alabama At Birmingham
- University Of Arizona
- University Of California
- University Of Dundee
- University Of Illinois
- University Of Michigan
- University Of Ottawa
- University Of Pennsylvania
- University Of Saskatchewan
- University Of Texas
- Washington University In Saint Louis
- Wisconsin Alumni Research Foundation
- The Wistar Institute
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