Castration Resistant Prostate Cancer: Clinical Insights from a US Oncologists' SurveyThe Assessment GroupMarch 11, 2011 24 Pages - SKU: TAG6278367 |
Additional Information
Report ExcerptsMetastatic prostate cancer is a cancer that has spread outside the prostate gland to the bladder or rectum as well as lymph nodes, bones or other areas. While treatment can control its spread and related symptoms, currently no treatment provides a cure. Treatment selection depends on many factors including previous treatment, site of recurrence, comorbid conditions, and patient preferences. Some men with a rising prostate-specific antigen (PSA) are treated similarly to those with advanced prostate cancer. In prostate cancer, testosterone can cause prostate tumors to grow. Drugs, surgery, and other hormones are used to reduce testosterone or to block it. Androgen deprivation therapy (ADT) is usually recommended first. If cancer returns following ADT, the cancer is termed androgen resistant. In addition to ADT, secondary hormone therapy may be considered. When patients stop responding to all forms of hormone treatment, the cancer is termed castrate resistant prostate cancer. The next step in treatment is chemotherapy or immunotherapy. If cancer spreads to the bones, ADT may control the cancer that has spread to the bones. Radiation may also relieve the pain.
- Executive Summary:
- Chapter 1: Introduction
- Table 1. Treatment Options in Advanced Prostate Cancer
- Chapter 2: Respondent Demographics
- Table 2.1 Eligibility Criteria for Survey Participation
- Figure 2.1 Gender of Survey Respondents
- Figure 2.2 Years Since Medical School Graduation
- Figure 2.3 Practice Settings
- Figure 2.4 Practices in NCI Cancer Centers
- Figure 2.5 Geographic Settings
- Figure 2.6 Survey Respondents by States
- Figure 2.7 Number of Physicians in Practice Groups
- Figure 2.8 Minimal Acceptable Level of Evidence in Determining Treatment Regimen
- Chapter 3: Elderly patient treated for Gleason’s 7 adenocarcinoma, increased PSA 18 months later
- Figure 3.1 Barriers to optimal treatment
- Figure 3.2 Confidence in treating to optimal outcome
- Figure 3.3 Treatment following rising PSA on leuprolide
- Figure 3.4 Treatment decision upon disease progression
- Figure 3.5 Factors that influenced treatment
- Table 3.1 Factors that influenced treatment by types of agents selected
- Figure 3.6 Other agents that would be appropriate to include in therapy
- Figure 3.7 Treatment upon rising PSA
- Figure 3.8 Treatment upon further disease progression
- Chapter 4. Patient with Gleason’s 3+4 adenocarcinoma and multiple metastases to pelvis and spine develops castration-resistant disease.
- Figure 4.1 Treatment Choices
- Figure 4.2 Confidence in treating to optimal outcome
- Figure 4.3 Cycles of docetaxel that the patient should receive
- Figure 4.4 Option to Continue LHRH agonist
- Figure 4.5 Factors Associated with Continuing LHRH Agonist
- Figure 4.6 Next Therapy with Good Performance Status upon Progressing after Docetaxel
- Chapter 5: Summary
- Appendix A: Survey Instrument
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