The Rheumatoid Arthritis Market Competitive Landscape and Clinical Stage AnalysisArrowhead PublishersMay 26, 2009 125 Pages - SKU: AH2467615 |
- 1 EXECUTIVE SUMMARY
- 1.1 Scope and Methodology
- 1.2 Rheumatoid Arthritis: Disease Background, Impact and Treatment
- 1.3 Market Growth
- 1.4 Research and Development (R&D) Trends
- 2 RHEUMATOID ARTHRITIS: SCIENTIFIC BACKGROUND
- 2.1 Disease Overview
- 2.2 Etiology of Rheumatoid Arthritis
- 2.2.1 Genetic Factors
- 2.3 The Immune Response
- 2.3.1 Cytokines
- 2.3.2 Helper T-Cells and RA
- 2.3.3 Leukocytes
- 2.4 Symptoms
- 2.5 Diagnosis
- 2.5.1 Diagnostic Criteria
- 2.6 Risk Factors
- 2.6.1 Genetic Factors
- 2.6.2 Stress Hormones
- 2.6.3 Gender
- 2.6.4 Age
- 2.6.5 Family History
- 2.6.6 Ethnic Background
- 2.7 Key Clinical Trial Endpoints
- 2.7.1 American College of Rheumatology (ACR) Disease Activity Measures
- 2.7.2 EULAR (European League Against Rheumatism) Response Criteria
- 2.7.3 Erythrocyte Sedimentation Rate (ESR)
- 2.7.4 C-Reactive Proteins (CRP)
- 2.8 Prognosis
- 3 THE FINANCIAL AND DEMOGRAPHIC IMPACT OF RHEUMATOID ARTHRITIS
- 3.1 The Prevalence and Incidence of Rheumatoid Arthritis
- 3.1.1 Worldwide
- 3.1.2 US
- 3.2 The Financial Impact of Rheumatoid Arthritis
- 4 CURRENT TREATMENT OPTIONS FOR RHEUMATOID ARTHRITIS
- 4.1 NSAIDs
- 4.2 Corticosteroids
- 4.3 Disease-Modifying Antirheumatic Drugs (DMARDs)
- 4.4 Biological Response Modifiers (BRMs)
- 4.4.1 Key Biological Response Modifiers
- 4.5 Surgical Treatments
- 4.5.1 Osteotomy
- 4.5.2 Synovectomy
- 4.5.3 Arthroscopic Surgery
- 4.5.4 Arthroplasty
- 4.5.5 Arthrodesis
- 4.6 Other Existing Treatments
- 5 ISSUES AND TRENDS IMPACTING THE GLOBAL MARKET FOR RA THERAPIES
- 5.1 Biological Response Modifiers as a Continued Market Force
- 5.2 DMARDs vs BRMs
- 5.3 The High Cost of RA Biologics
- 5.4 Medicare Reform in the US: Impact on RA Market
- 5.5 RA Therapies and Global Reimbursement Issues
- 6 THE GLOBAL MARKET FOR RA THERAPIES
- 6.1 Commercial Market Size
- 6.1.1 US Revenues
- 6.1.2 Non-US Revenues
- 6.2 Key Products Driving Growth
- 6.2.1 Enbrel: Market Position and Revenues
- 6.2.2 Remicade: Market Position and Revenues
- 6.2.3 Humira: Market Position and Revenues
- 6.2.4 Orencia: Market Position and Revenues
- 6.2.5 Rituxan: Market Position and Revenues
- 6.2.6 Kineret: Market Position and Revenues
- 6.3 Market Share
- 6.3.1 By Product
- 6.3.2 By Country/Region
- 7 THE R&D PIPELINE FOR RA THERAPIES
- 7.1 Unmet Need
- 7.2 R&D Trends in RA Therapy
- 7.2.1 Products Nearing Commercialization
- 7.2.2 Future Directions
- 7.3 R&D Trends in RA Therapy
- 7.3.1 Cimzia (CDP-870)
- 7.3.2 Actemra
- 7.3.3 Simponi
- 7.4 Selected Phase III Products in Development
- 7.4.1 Arzerra (HuMax-CD 20)
- 7.4.2 CP-690550
- 7.4.3 Ocrelizumab (R1594)
- 7.5 Selected Phase II Products in Development
- 7.5.1 Eculizumab
- 7.5.2 INCB018424
- 7.5.3 ALD-518
- 7.5.4 P38 MAP Kinase Inhibitor
- 7.5.5 BMS 561392
- 7.5.6 Lymphostat-B
- 7.5.7 VX 702
- 8 THE FINANCIAL OUTLOOK FOR THE RA THERAPY MARKET
- 8.1 Financial Forecasts for Key Products
- 8.1.1 Enbrel
- 8.1.2 Remicade
- 8.1.3 Humira
- 8.1.4 Orencia
- 8.1.5 Rituxan
- 8.2 Overall Financial Forecast for RA Market 2009-2013
- GRAPHS
- Graph 3.1 Prevalence of RA in Various Countries
- Graph 6.1 Global Sales of Leading RA Therapies 2003-2008, by product ($ mn)
- Graph 6.2 US Sales of Leading RA Therapies 2003-2008, by product ($ mn)
- Graph 6.3 Non-US Sales of Leading RA Therapies 2003-2008, by product ($ mn)
- Graph 6.4 Enbrel Market Share, by Country/Region 2008
- Graph 6.5 Remicade Market Share, by Country/Region 2008
- Graph 6.6 Humira Market Share, by Country/Region 2008
- Graph 6.7 Orencia Market Share, by Country/Region 2008
- Graph 6.8 Global Market Share of Leading RA Therapies by Product, 2008
- Graph 6.9 US Market Share of Leading RA Therapies by Product, 2008
- Graph 6.10 Non-US Market Share of Leading RA Therapies by Product, 2008
- Graph 6.11 RA Therapy Market Share, by Country/Region 2008
- Graph 8.1 Sales Forecast for Enbrel 2009-2013
- Graph 8.2 Sales Forecast for Remicade 2009-2013
- Graph 8.3 Sales Forecast for Humira 2009-2013
- Graph 8.4 Sales Forecast for Orencia 2009-2013
- Graph 8.5 Sales Forecast for Rituxan 2009-2013
- FIGURES
- Figure 4.1 Treatment Options for Rheumatoid Arthritis
- TABLES
- Table 4.1 Percent of Patients with ACR Responses in Studies 1 and 3
- Table 5.1 Approved DMARDs for Rheumatoid Arthritis
- Table 5.2 Profiles of the Leading DMARDs and BRMs (2008)
- Table 6.1 Global Sales of Key BRMs for Rheumatoid Arthritis, 2003-2008 ($ million)
- Table 6.2 US Sales of Leading RA Therapies 2003-2008 ($ mn)
- Table 6.3 Non-US Sales of Leading RA Therapies 2003-2008 ($ mn)
- Table 6.4 Global Sales of Enbrel, US & Canada, Rest of World 2003-2008 ($ mn)
- Table 6.5 Sales of Remicade 2003-2008, US, Japan, Europe + Rest of World ($ mn)
- Table 6.6 Global Sales of Humira, US, Rest of World 2003-2008 ($ mn)
- Table 6.7 Global Sales of Orencia, US, Rest of World 2006-2008 ($ mn)
- Table 7.1 Rheumatoid Arthritis Drugs in Late-Stage Development
- Table 7.2 Rheumatoid Arthritis Drugs in Early-Stage Development
- Table 8.1 Patent Expirations for Key RA Products
- Table 8.2 Financial Growth Forecast of the Biologics in the RA Market 2009-2013 ($ mn)
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