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Lung Cancer Therapeutics Market Outlook and Pipeline Analysis

Arrowhead Publishers
November 1, 2009
SKU: AH2523979

Abstract Table of Contents Search inside this report Related Reports

With over 50% of all non-small cell lung cancer (NSCLC) patients diagnosed at the advanced stages of the disease, and 95% of all small-cell lung cancer (SCLC) patients unsuitable for surgical resection, drug therapy plays a vital role in the management of lung cancer. Such high level of unmet need ensures the lung cancer market is an attractive commercial opportunity for new drug development.

Lung Cancer Therapeutics Market & Pipeline Analysis supports the process of successful product development and commercialization within the pharmaceutical/biopharmaceutical lung cancer market by addressing the following key areas:

Epidemiology of lung cancer
Current lung cancer treatments
Analysis of current lung cancer therapeutics
Unmet needs within the lung cancer market
Research and development (R&D) approaches towards lung cancer
Pipeline analysis of key lung cancer candidates
Forecast sales of key pipeline lung cancer candidates

The report also analyzes the market status and potential for the following key lung cancer therapies:

Sanofi-Aventis’ Taxotere (docetaxel)
Eli-Lilly’s Gemzar (gemcitabine)
Eli-Lilly’s Alimta (pemetrexed)
GlaxoSmithKline’s Hycamtin (topotecan) (SCLC therapeutic)
OSI Pharmaceuticals/Roche’s Tarceva (erlotinib)
AstraZeneca’s Iressa (gefitinib)
Roche’s Avastin (bevazicumab)

and the market potential for the following key late-clinical stage developmental candidates:

Opaxio
Erbitux (line extensions)
Zactima
Picoplatin

This in-depth, quality report delivers:

An assessment of the lung market potential, including identification of unmet needs, commercial opportunities, and key trends in R&D
Analysis of the lung cancer pipeline with in-depth clinical and commercial assessment of key Phase III candidates
Seven major pharmaceutical market sales forecasts to 2015 for key pipeline candidates incorporating product events

Report highlights include:

Arrowhead has identified 70 drugs in the late-stage lung cancer pipeline. Collectively, key late-phase products have a forecast sales potential of up to $5651m by 2015 in the seven major pharmaceutical markets.
Molecular targeted therapies (MTTs) are the focus of R&D in lung cancer. Of the MTTs in late-phase development, Erbitux (cetuximab; ImClone /Bristol-Myers Squibb/Merck KGaA) is forecast to achieve the highest level of sales, with $1000m by 2015.
Arrowhead forecasts AstraZeneca’s Iressa (gefitinib) will overcome its disappointing start in the NSCLC arena following positive results of two recent Phase III trials. Iressa will go on to compete well with Roche’s Avastin and OSI Pharma/Roche’s Tarceva (erlotinib).

Purchasing this report will enable you to:

Assess opportunities and risks influencing R&D in lung cancer, unmet needs in the treatment of the disease, and trends in current development
Identify key lung cancer products in late-phase development based on sales forecasts to 2015 to maximize your product’s commercial potential
Gain an impartial perspective of the strategies used between competing companies involved in the lung cancer pipeline to enhance your product’s performance

1 EXECUTIVE SUMMARY: 1.1 Scope of Lung Cancer Therapeutics: Market Trends and R&D Insights; 1.2 Methodology of Lung Cancer Therapeutics: Market Trends and R&D Insights; 1.3 Lung Cancer Epidemiology Trends; 1.4 Current Therapeutic Treatments of Lung Cancer; 1.5 Unmet Needs of Lung Cancer; 1.6 Research and Development (R&D) Trends; 1.7 Pipeline Analysis
2 LUNG CANCER: DISEASE BACKGROUND: 2.1 An Introduction to Lung Cancer; 2.2 An Overview of Non Small Cell Lung Cancer (NSCLC); 2.3 Large Cell Carcinoma; 2.4 Staging of NSCLC; 2.5 Small Cell Lung Cancer (SCLC); 2.6 Staging of SCLC; 2.7 Lung Cancer Risk Factors; 2.8 Lung Cancer Symptoms; 2.9 Diagnosis of Lung Cancer; 2.10 Prognosis of Lung Cancer
3 EPIDEMIOLOGICAL AND FINANCIAL IMPACT OF CANCER: 3.1 Epidemiology of Lung Cancer in the Seven Major Markets; 3.2 The Financial Impact of Lung Cancer; 3.3 Would a Lung Cancer Screening Program Impact Patient Survivorship and Reduce the Financial Cost of the Disease?
4 CURRENT LUNG CANCER MANAGEMENT CONTROVERSIES: 4.1 An Introduction to the Management of Lung Cancer; 4.2 An Overview to the Surgical Resection of Lung Cancer; 4.3 An Overview of Radiation Therapy for Lung Cancer; 4.4 An Overview of Chemotherapy for Lung Cancer; 4.5 First-Line Cytotoxic Management of Lung Cancer; 4.6 Second- and Third-Line Cytotoxic Management of Lung Cancer; 4.7 Molecular Targeted Therapies (MTTs) Used in the Management of NSCLC; 4.8 Neo-adjuvant and Adjuvant Lung Cancer Chemotherapy
5 ANALYSIS OF THE LUNG CANCER THERAPEUTICS MARKET: 5.1 First-Line Therapies; 5.2 Key Branded Cytotoxic Therapies; 5.3 SWOT Analysis: Taxotere; 5.4 SWOT Analysis: Alimta; 5.5 SWOT Analysis: Gemzar; 5.6 SWOT Analysis: Hycamtin; 5.7 Key Molecular-Targeted Therapies (MTTs)
6 UNMET NEEDS IN THE LUNG CANCER THERAPEUTIC MARKET: 6.1 Unmet Needs in the Lung Cancer Market; 6.2 Five-year Survival Rates Remain Static; 6.3 Extensive-Stage SCLC Specific Agent; 6.4 First-line Agents that Prevent Disease Relapse; 6.5 First-line Agents with Favorable Toxicity Profiles; 6.6 Elderly Lung Cancer Patients are Underserved; 6.7 Effective Second-Line Agents; 6.8 Bronchioalveolar Carcinoma Patients are Underserved; 6.9 Stage IIIA Specific Agent; 6.10 Development of a Cost-Effective Lung Cancer Screening Program; 6.11 Development of a Chemo-Preventative
7 LUNG CANCER RESEARCH AND DEVELOPMENT (R&D) TRENDS: 7.1 An Introduction to Oncology Clinical Trials; 7.2 Issues Surrounding the Design of Lung Cancer Clinical Trials; 7.3 An Introduction to Oncology Clinical Trial Endpoints; 7.4 Emerging Lung Cancer Biomarkers May Aid R&D Direction
8 LUNG CANCER PIPELINE ANALYSIS: 8.1 Introduction to the Lung Cancer Therapeutics Pipeline; 8.2 ImClone/Bristol-Myers Squibb/Merck KGaA’s Erbitux (cetuximab); 8.3 Cell Therapeutics’ Opaxio (polyglutamate paclitaxel); 8.4 AstraZeneca’s Zactima (vandetanib); 8.5 Poniard Pharmaceuticals’ Picoplatin; 8.6 Financial Forecast of the Therapeutic Lung Cancer Market
TABLES: Table 1: Lung Cancer Incidence Forecast in 2009 and 2019 in the Seven Major Markets; Table 2: Worldwide Branded Therapeutics Indicated for Lung Cancer Revenues ($million) 2007, 2008 and H2- 2009; Table 3: AJCC TNM Staging System of NSCLC; Table 4: AJCC TNM Staging System of NSCLC; Table 5: Veterans Administration Lung Study Group (VALG) Staging of SCLC; Table 6: Lung Cancer Diagnosis and Five-Year Survival Rate by Disease Stage; Table 7: NSCLC Five-year Survival Rate by Disease Stage in the US and Across Europe; Table 8: Diagnosis and Survival Rate for Untreated and Treated SCLC Patients by Disease Stage; Table 9: Crude Incidence Rate of Lung Cancer by Gender (per 100,000) in the Seven Major Markets, 2009; Table 10: Lung Cancer Incidence Forecast in Males in the Seven Major Markets, 2008-2019; Table 11: Lung Cancer Incidence Forecast in Females in the Seven Major Markets, 2008-2019; Table 12: Lung Cancer Incidence Forecast in the Seven Major Markets, 2008-2019; Table 13: NSCLC Incidence Forecast in the Seven Major Markets, 2008-2019; Table 14: Stage-Specific Incidence of NSCLC in 2009; Table 15: SCLC Incidence Forecast in the Seven Major Markets, 2008-2019; Table 16: Stage-Specific Incidence of SCLC in the Seven Major Markets, 2009; Table 17: Cytotoxics Used in Lung Cancer by Generic Name, Brand Name, Company and Line-Setting; Table 18: Worldwide Branded Cytotoxic Lung Cancer Therapeutics Revenues ($million) 2007, 2008 and H2- 2009; Table 19: Branded Lung Cancer Cytotoxic Agents’ US Patent Approval and Expiry Dates; Table 20: SWOT Analysis of Taxotere; Table 21: SWOT Analysis of Alimta; Table 22: SWOT Analysis of Gemzar; Table 23: SWOT Analysis of Hycamtin; Table 24: Worldwide Branded MTT NSCLC Therapeutics Revenues ($million) 2007, 2008 and H2- 2009; Table 25: Branded Lung Cancer MTT Agents US Patent Approval and Expiry Dates; Table 26: SWOT Analysis of Avastin; Table 27: SWOT Analysis of Tarceva; Table 28: SWOT Analysis of Iressa; Table 29: Lung Cancer Diagnosis and Five-Year Survival by Disease Stage; Table 30: Key Phase III Clinical Trials Involving Elderly Advanced NSCLC Patients; Table 31: Late-Stage NSCLC Therapeutic Pipeline, Aug 2009; Table 32: Late-Stage SCLC Therapeutic Pipeline, Aug 2009; Table 33: STELLAR-3 and STELLAR-4 Survival Data; Table 34: Worldwide Lung Cancer Therapeutic Forecast Sales ($million), 2008-2015
FIGURES: Figure 1: Lung Cancer Incidence Forecast in 2009 and 2019 in the Seven Major Markets; Figure 2: Clinical Unmet Needs in the Lung Cancer Therapeutic Market; Figure 3: The Anatomy of the Human Respiratory System; Figure 4: Lung Cancer Incidence Forecast in the Seven Major Markets, 2008-2019; Figure 5: NSCLC Incidence Forecast in the Seven Major Markets, 2008-2019; Figure 6: Stage-Specific Incidence of NSCLC in 2009; Figure 7: SCLC Incidence Forecast in the Seven Major Markets, 2008-2019; Figure 8: Stage-Specific Incidence of SCLC in the Seven Major Markets, 2009; Figure 9: NCCN Recommendations for the Chemotherapeutic Management of PS 0-2 Stage IV or Relapsed NSCL; Figure 10: NCCN Recommendations for the Chemotherapeutic Management of PS0-2 Limited (in excess T1-2, N0) and Extensive Stage SCLC

Lung Cancer Therapeutics Market Outlook and Pipeline Analysis

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