Evidence-Based Medicine: Current Use and Future Impact on Global Clinical and Reimbursement PracticesArrowhead PublishersMay 19, 2008 181 Pages - SKU: AH1829674 |
- 1 Methodology and Executive Summary
- 1.1 Report Objectives
- 1.2 Report Methodology
- 1.3 Executive Summary
- 1.3.1 EBM and Pharmaceutical Reimbursement
- 1.3.2 Future of EBM
- 2 Evidence-Based Medicine - Overview
- 2.1 Definitions
- 2.2 Types of Evidence-Based Medicine
- 2.3 Methodology Used by Evidence-Based Medicine
- 2.4 History of Evidence-Based Medicine
- 2.5 Impact on Policy-Formation
- 2.5.1 Depth of Reimbursement
- 2.5.2 Breadth of Reimbursement
- 3 Evidence-Based Medicine - Classification and Recommendations
- 3.1 Overview
- 3.2 US Preventive Services Task Force Stratification System
- 3.3 UK Stratification Systems
- 4 Evidence-Based Medicine - Advantages and Limitations
- 4.1 Advantages
- 4.2 Limitations
- 5 Evidence-Based Medicine - Current Trends
- 5.1 Healthcare on the Global Level
- 5.2 EBM and Pharmaceutical Reimbursement
- 5.3 EBM Case Studies - Therapeutic Areas
- 5.3.1 Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS)
- 5.3.2 Alzheimer’s Disease
- 5.3.3 Cardiovascular Disease
- 5.3.4 Inflammatory Disease
- 5.3.5 Breast Cancer
- 6 EBM Case Studies - Countries
- 6.1 EBM Case Studies - Australia
- 6.1.1 Regulatory Environment
- 6.1.2 The Role of Evidence-Based Medicine
- 6.1.3 Examples of Evidence-Based Medicine in Reimbursement
- 6.1.4 Future Developments
- 6.2 EBM Case Studies - Canada
- 6.2.1 Regulatory Environment
- 6.2.2 The Role of Evidence-Based Medicine
- 6.2.3 Examples of Evidence-Based Medicine in Reimbursement
- 6.2.4 Future Developments
- 6.3 EBM Case Studies - United Kingdom
- 6.3.1 Regulatory Environment
- 6.3.2 Health Insurance
- 6.3.3 The Role of Evidence-Based Medicine
- 6.3.4 Examples of Evidence-Based Medicine in Reimbursement
- 6.3.5 Future Developments
- 7 Discussion of Evidence-Based Medicine in Clinical and Reimbursement Practices of Other Major Markets
- 7.1 Germany
- 7.1.1 Regulatory Environment
- 7.1.2 Health Insurance
- 7.1.3 The Role of Evidence-Based Medicine
- 7.1.4 Future Developments
- 7.2 Japan
- 7.2.1 Regulatory Environment
- 7.2.2 Health Insurance
- 7.2.3 The Role of Evidence-Based Medicine
- 7.2.4 Future Developments
- 7.3 United States
- 7.3.1 Regulatory Environment
- 7.3.1.1 Regulatory Environment - Pricing
- 7.3.1.2 Regulatory Environment - Reimbursement
- 7.3.2 Health Insurance
- 7.3.2.1 Medicare
- 7.3.2.2 Medicaid
- 7.3.3 The Role of Evidence-Based Medicine
- 7.3.3.1 The Role of Evidence-Based Medicine: Case Study - Cox-2 Class
- 7.3.4 EBM and Federal Agencies
- 7.3.5 EBM and Individual States
- 7.3.6 EBM and Insurance Companies
- 7.3.7 ‘Pay-for-Performance’ Schemes
- 7.3.8 ‘Risk-Sharing’ Schemes
- 7.3.9 EBM and Managed Care
- 7.3.10 Barriers to EBM’s Application
- 7.3.11 Future Developments
- 7.3.11.1 Demand for Individualized Care
- 7.3.11.2 EBM and Pharmaceutical Reimbursement
- 7.3.11.3 Lessons Learned
- 7.3.11.4 Lessons from Elsewhere
- 7.3.11.5 Striking the Right Balance
- 8 The Future of Evidence-Based Medicine
- 8.1 Developments Driving Wider Application of EBM
- 8.1.1 Epidemiology and Demographics
- 8.1.2 Biotechnology and Biogenerics
- 8.1.3 Orphan Drugs
- 8.1.4 Health Economics
- 8.1.5 The Need for Cost-Containment in Pharmaceutical Reimbursement
- 8.1.6 Practical Benefits of Standardized Procedures
- 8.1.7 Drug Lifecycle Management
- 8.1.8 Countries Following Suit of Trend-Setters
- 8.2 Developments Hampering Wider Application of EBM
- 8.2.1 Compliance with Guidelines
- 8.2.2 Information Overload
- 8.2.3 Lack of Public Funding for Medical Research
- 8.2.4 Demand for Tailor-Made Medicine
- 8.3 The End Result - Application of EBM
- 9 Conclusions and Recommendations
- 10 Appendix
- 10.1 Glossary of Terms
- 10.2 EBM Resources
- 10.3 Select EBM Guidelines
- 10.3.1 Agency for Healthcare Research and Quality (AHRQ)
- 10.3.2 National Institute of Clinical Excellence (NICE)
- 10.3.3 National Breast and Ovarian Cancer Centre (NBOCC)
- 10.4 Evidence-Based Medicine Databases
- Tables
- Table 2.1 EBM Process
- Table 3.1 Classification of Evidence
- Table 3.2 Ratings of Diagnostic and Prognostic Articles
- Table 4.1 Arguments Used by Critics and Supporters of EBM
- Table 5.1 Table Overview of Pricing and Reimbursement Measures in Select EU Countries
- Table 5.2 Global Pharmaceutical Sales, 1999 - 2006
- Table 5.3 Global Pharmaceutical Sales by Region, 2006
- Table 5.4 Global Pharmaceutical Sales by Select Countries
- Table 5.5 PE Guidelines around the World
- Table 5.6 Epidemic Profiles
- Table 5.7 Cost-Effectiveness of Care and Treatment for HIV/AIDS
- Table 5.8 Cost-Effectiveness of HIV Interventions
- Table 5.9 Cost-Effectiveness by Epidemic Profile
- Table 6.1 Recent Reimbursement Recommendations by NICE
- Table 7.1 Examples of Pharmaceuticals Granted Usefulness Premiums
- Table 7.2 Premium Reimbursement Categories and Rates
- Table 7.3 Main Types of Health Insurance in the USA
- Table 7.4 Avoidable Death and Medical Costs Due to Unexplained Variations n Care
- Table 7.5 Select Health Insurance Companies in the US
- Table 7.6 From Managed Care to Care Management
- Table 7.7 Main Obstacles to EBM‘s Application
- Table 8.1 Drivers and Constraints of EBM
- Table 8.2 Select Orphan Drugs
- Graphs
- Graph 5.1 Public Share of Total Expenditure on Health, 2005
- Graph 5.2 Health Expenditure per Capita, Public and Private, 2005
- Graph 7.1 Public Share of Total Expenditure on Health, 2005
- Graph 7.2 Public Share of Expenditure on Medical Services and Pharmaceuticals, 2005
- Graph 7.3 Out-of-Pocket and Private Health Insurance spending as a Share of Total Health Expenditure, 2005
- Graph 7.4 Total Health Expenditure as a Share of GDP, 2005
- Graph 7.5 Coverage by Type of Health Insurance
- Graph 8.1 Global Burden of Non-Communicable Diseases
- Figures
- Figure 8.1 Global Population by Age
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