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1 Overview
1.1 Lines of Business
1.2 Products
1.3 Technology
1.4 Marketing
1.5 Employees
2 Amgen Strategy
2.1 Amgen Strengths
2.2 Amgen Weaknesses
2.3 Amgen's Strategy Going Forward
2.3.1 The Quest for Small Molecule Therapeutics
2.3.2 R&D Productivity
2.3.3 Partnering with Smaller Biotechs
2.4 Amgen Ventures
2.4.1 Amgen Venture's First Investment - Accelerator
2.5 Potential Problems Facing Amgen
2.6 The Next Billion Dollar Therapeutic?
2.6.1 ENBREL® (etanercept)
2.6.2 Sensipar® (cinacalcet HCl)
2.6.3 Kepivance® (palifermin)
2.6.4 Panitumumab®
2.6.5 AMG 162
3 Key Events 2004
4 Key Products
4.1 EPOGEN®
4.2 Aranesp®
4.3 NEUPOGEN®
4.4 Neulasta®
4.5 ENBREL®
4.6 Additional Products
4.6.1 Kineret®
4.6.2 Sensipar®
4.6.3 Kepivance ™
5 Drug Pipeline
6 Recent Clinical Trials Results
7 Joint Ventures and Collaborations
7.1 Key Joint Ventures
7.1.1 Kirin Brewery Company, Limited
7.1.2 Wyeth
7.1.3 Johnson & Johnson
7.1.4 Genentech
7.1.5 NPS Pharmaceuticals
7.2 Additional Collaborations
7.2.1 GenData
7.2.2. Dyax
7.2.3 ZymoGenetics
7.2.4 Immunomedics
7.2.5 Cambridge Antibody Technologies
7.2.6 Infinity Pharmaceuticals
7.2.7 ViaCell, Inc.
7.2.8 Biovitrum
7.2.9 Epimmune
7.2.10 NeoGenesis Pharmaceuticals
7.2.11 Anadys Pharmaceuticals
7.2.12 Genome Therapeutics / Oscient Pharmaceuticals
7.2.13 BioFocus
7.2.14 Abgenix
7.2.15 Medarex
7.2.16 GenMab
8 Recent Acquisitions
9 Manufacturing and Suppliers
10 Litigation and Contract Disputes
10.1 Patent Disputes
10.1.1 Transkaryotic Therapies and Aventis
10.1.2 Israel Bio-Engineering
10.1.3 Columbia University
10.2 Class Action/Government Investigations
10.3 Contractual Disputes
10.4 Disputes Involving Amgen Medication
11 Amgen Financials
Discussion of Financials
12 Sales of Amgen Key Products
13 Amgen’s US Patents
13.1 Amgen's US Granted Patents: 2002 - 2004
13.2 Amgen's 2004 Granted Patents
13.3 Amgen's 2003 Granted Patents
13.4 Amgen's 2002 Granted Patents
Appendix A Key Patent Expirations
Appendix B Amgen US Patent Applications: 2004 through 1st Quarter 2005
Appendix C Key Biographies
Tables
Table 5.1 Oncology Pipeline
Table 5.2 Inflammation Pipeline
Table 5.3 Metabolic Disorder Pipeline
Table 5.4 Neuroscience Pipeline
Table 5.5 General Medicine/Other Pipeline
Table 9.1 Amgen Products and Manufacturing Sites
Table 11.1 Three Year Key Financials
Graphs
Graph 12.1 Total Worldwide Product Sales, 2002-2004
Graph 12.2 2004 U.S. vs. International Sales of Products
Graph 12.3 Worldwide Sales of EPOGEN®, 2002-2004
Graph 12.4 Worldwide Sales of Aranesp®, 2002-2004
Graph 12.5 2004 U.S. vs. International Sales of Aranesp®
Graph 12.6 Worldwide Sales of NEUPOGEN® 2002-2004
Graph 12.7 2004 U.S. vs. International Sales of NEUPOGEN®
Graph 12.8 Worldwide Sales of Neulasta® 2002-2004
Graph 12.9 2004 U.S. vs. International Sales of NEULASTA®
Graph 12.10 Worldwide Sales of ENBREL® 2002-2004
Graph 12.11 2004 U.S. vs. International Sales of ENBREL®
Graph 13.1 Granted Patents Based on Therapeutic Area
Graph 13.2 Granted Patents Based on Therapeutic Form
Graph 13.3 Amgen 2004 Patents Based on Therapeutic Area
Graph 13.4 Amgen's 2004 Granted Patents Based on Therapeutic Form
Graph 13.5 Amgen 2003 Patents Based on Therapeutic Area
Graph 13.6 Amgen's 2003 Granted Patents Based on Therapeutic Form
Graph 13.7 Amgen's 2002 Granted Patents by Therapeutic Area
Graph 13.8 Amgen's 2002 Granted Patents by Therapeutic Form
1.1 Lines of Business
1.2 Products
1.3 Technology
1.4 Marketing
1.5 Employees
2 Amgen Strategy
2.1 Amgen Strengths
2.2 Amgen Weaknesses
2.3 Amgen's Strategy Going Forward
2.3.1 The Quest for Small Molecule Therapeutics
2.3.2 R&D Productivity
2.3.3 Partnering with Smaller Biotechs
2.4 Amgen Ventures
2.4.1 Amgen Venture's First Investment - Accelerator
2.5 Potential Problems Facing Amgen
2.6 The Next Billion Dollar Therapeutic?
2.6.1 ENBREL® (etanercept)
2.6.2 Sensipar® (cinacalcet HCl)
2.6.3 Kepivance® (palifermin)
2.6.4 Panitumumab®
2.6.5 AMG 162
3 Key Events 2004
4 Key Products
4.1 EPOGEN®
4.2 Aranesp®
4.3 NEUPOGEN®
4.4 Neulasta®
4.5 ENBREL®
4.6 Additional Products
4.6.1 Kineret®
4.6.2 Sensipar®
4.6.3 Kepivance ™
5 Drug Pipeline
6 Recent Clinical Trials Results
7 Joint Ventures and Collaborations
7.1 Key Joint Ventures
7.1.1 Kirin Brewery Company, Limited
7.1.2 Wyeth
7.1.3 Johnson & Johnson
7.1.4 Genentech
7.1.5 NPS Pharmaceuticals
7.2 Additional Collaborations
7.2.1 GenData
7.2.2. Dyax
7.2.3 ZymoGenetics
7.2.4 Immunomedics
7.2.5 Cambridge Antibody Technologies
7.2.6 Infinity Pharmaceuticals
7.2.7 ViaCell, Inc.
7.2.8 Biovitrum
7.2.9 Epimmune
7.2.10 NeoGenesis Pharmaceuticals
7.2.11 Anadys Pharmaceuticals
7.2.12 Genome Therapeutics / Oscient Pharmaceuticals
7.2.13 BioFocus
7.2.14 Abgenix
7.2.15 Medarex
7.2.16 GenMab
8 Recent Acquisitions
9 Manufacturing and Suppliers
10 Litigation and Contract Disputes
10.1 Patent Disputes
10.1.1 Transkaryotic Therapies and Aventis
10.1.2 Israel Bio-Engineering
10.1.3 Columbia University
10.2 Class Action/Government Investigations
10.3 Contractual Disputes
10.4 Disputes Involving Amgen Medication
11 Amgen Financials
Discussion of Financials
12 Sales of Amgen Key Products
13 Amgen’s US Patents
13.1 Amgen's US Granted Patents: 2002 - 2004
13.2 Amgen's 2004 Granted Patents
13.3 Amgen's 2003 Granted Patents
13.4 Amgen's 2002 Granted Patents
Appendix A Key Patent Expirations
Appendix B Amgen US Patent Applications: 2004 through 1st Quarter 2005
Appendix C Key Biographies
Tables
Table 5.1 Oncology Pipeline
Table 5.2 Inflammation Pipeline
Table 5.3 Metabolic Disorder Pipeline
Table 5.4 Neuroscience Pipeline
Table 5.5 General Medicine/Other Pipeline
Table 9.1 Amgen Products and Manufacturing Sites
Table 11.1 Three Year Key Financials
Graphs
Graph 12.1 Total Worldwide Product Sales, 2002-2004
Graph 12.2 2004 U.S. vs. International Sales of Products
Graph 12.3 Worldwide Sales of EPOGEN®, 2002-2004
Graph 12.4 Worldwide Sales of Aranesp®, 2002-2004
Graph 12.5 2004 U.S. vs. International Sales of Aranesp®
Graph 12.6 Worldwide Sales of NEUPOGEN® 2002-2004
Graph 12.7 2004 U.S. vs. International Sales of NEUPOGEN®
Graph 12.8 Worldwide Sales of Neulasta® 2002-2004
Graph 12.9 2004 U.S. vs. International Sales of NEULASTA®
Graph 12.10 Worldwide Sales of ENBREL® 2002-2004
Graph 12.11 2004 U.S. vs. International Sales of ENBREL®
Graph 13.1 Granted Patents Based on Therapeutic Area
Graph 13.2 Granted Patents Based on Therapeutic Form
Graph 13.3 Amgen 2004 Patents Based on Therapeutic Area
Graph 13.4 Amgen's 2004 Granted Patents Based on Therapeutic Form
Graph 13.5 Amgen 2003 Patents Based on Therapeutic Area
Graph 13.6 Amgen's 2003 Granted Patents Based on Therapeutic Form
Graph 13.7 Amgen's 2002 Granted Patents by Therapeutic Area
Graph 13.8 Amgen's 2002 Granted Patents by Therapeutic Form
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